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1.
Int J Oral Maxillofac Surg ; 43(4): 506-13, 2014 Apr.
Article in English | MEDLINE | ID: mdl-24183512

ABSTRACT

In the present study, polycaprolactone-tricalcium phosphate (PCL/TCP) scaffolds with two different fibre laydown patterns, which were coated with hydroxyapatite and gelatine, were used as an approach for optimizing bone regeneration in a critical-sized calvarial defect. After 12 weeks, bone regeneration was quantified using microcomputed tomography (micro-CT) analysis, biomechanical testing, and histological evaluation. Notably, the experimental groups with coated scaffolds showed lower bone formation and lower biomechanical properties within the defect compared to the uncoated scaffolds. Surprisingly, the different laydown pattern of the fibres resulted in different bone formation and biomechanical properties: the 0°/60°/120° scaffolds revealed lower bone formation and biomechanical properties compared to the 0°/90° scaffolds in all the experimental groups. Therefore, future bone regeneration strategies utilizing scaffolds should consider scaffold architecture as an important factor during the scaffold optimization stages in order to move closer to a clinical application.


Subject(s)
Biocompatible Materials/pharmacology , Bone Regeneration/drug effects , Skull/surgery , Tissue Scaffolds/chemistry , Wound Healing/drug effects , Animals , Calcium Phosphates/pharmacology , Durapatite/pharmacology , Gels/pharmacology , Immunoenzyme Techniques , Microscopy, Electron, Scanning , Polyesters/pharmacology , Rats, Inbred Lew , Skull/diagnostic imaging , Surface Properties , X-Ray Microtomography
2.
J Biomater Sci Polym Ed ; 19(5): 693-707, 2008.
Article in English | MEDLINE | ID: mdl-18419946

ABSTRACT

In this study, a nanofiber mesh made by co-electrospinning medical grade poly(epsilon-caprolactone) and collagen (mPCL/Col) was fabricated and studied. Its mechanical properties and characteristics were analyzed and compared to mPCL meshes. mPCL/Col meshes showed a reduction in strength but an increase in ductility when compared to PCL meshes. In vitro assays revealed that mPCL/Col supported the attachment and proliferation of smooth muscle cells on both sides of the mesh. In vivo studies in the corpus cavernosa of rabbits revealed that the mPCL/Col scaffold used in conjunction with autologous smooth muscle cells resulted in better integration with host tissue when compared to cell free scaffolds. On a cellular level preseeded scaffolds showed a minimized foreign body reaction.


Subject(s)
Collagen/chemistry , Polyesters/chemistry , Animals , Cell Adhesion , Cell Proliferation , Cells, Cultured , Elasticity , Male , Myocytes, Smooth Muscle/cytology , Myocytes, Smooth Muscle/physiology , Nanotechnology , Rabbits , Swine
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