[The antihypoxic activity of endogenous cyclic derivatives of gamma-aminobutyric acid]. / Antigipoksicheskaia aktivnost' éndogennykh tsiklicheskikh proizvodnykh gamma-aminomaslianoi kisloty.

Pirrolidone-2, gamma-butyrolacton, succinic anhydride were found to possess pronounced antihypoxic activity that manifested itself in their ability to decrease the level of lactic acid accumulated during hypoxia. Pirrolidone-2 and succinic anhydride increase succinic dehydrogenase activity in vitro. At intraperitoneal administration the above mentioned compounds lead to lactate dehydrogenase activity inhibition under normal conditions while during circulatory hypoxia they stimulate lactate dehydrogenase reaction promoting the maintenance of energy balance of the cerebral tissue at the appropriate level.