ABSTRACT
The effect of adrenaline on the glucose uptake by a non-exercising hindlimb was studied in fasted anaesthetized dog. Glucose uptake (mg/min) was calculated as the product of the venous blood flow and anterio-venous glucose difference (A - V). Although, adrenaline caused significant increase in venous blood flow, it however, reduced significantly the (A - V) glucose level and the glucose uptake by the hindlimb. The adrenaline effects were however, abolished by pretreating the animal with propranolol, a beta-adrenergic blocker. It was therefore concluded that the skeletal muscle of the canine hindlimb is not involved in glucose homeostasis during adrenaline hyperglycemia.
Subject(s)
Adrenergic beta-Agonists/pharmacology , Blood Flow Velocity/drug effects , Epinephrine/pharmacology , Glucose/metabolism , Hindlimb/blood supply , Hindlimb/metabolism , Hyperglycemia/chemically induced , Hyperglycemia/metabolism , Muscle, Skeletal/blood supply , Muscle, Skeletal/metabolism , Adrenergic alpha-Antagonists/pharmacology , Adrenergic beta-Antagonists/pharmacology , Animals , Blood Glucose/analysis , Blood Glucose/drug effects , Blood Glucose/metabolism , Dogs , Fasting , Homeostasis , Hyperglycemia/physiopathology , Male , Prazosin/pharmacology , Propranolol/pharmacology , RestABSTRACT
The methanol extract of the stem bark of Alstonia boonei was investigated for anti-inflammatory property. The analgesic and antipyretic properties of the extract was also evaluated. The extract caused a significant (P<0.05) inhibition of the carrageenan-induced paw oedema, cotton pellet granuloma, and exhibited an anti-arthritic activity in rats. Vascular permeability induced by acetic acid in the peritoneum of mice was also inhibited. The extract also produced marked analgesic activity by reduction of writhings induced by acetic acid, as well as the early and late phases of paw licking in mice. A significant (P<0.05) reduction in hyperpyrexia in mice was also produced by the extract. This study has established anti-inflammatory, analgesic and antipyretic activities of the stem bark of A. boonei.
Subject(s)
Analgesics, Non-Narcotic/pharmacology , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Plants, Medicinal/chemistry , Acetic Acid , Africa , Analgesics, Non-Narcotic/isolation & purification , Animals , Anti-Inflammatory Agents, Non-Steroidal/isolation & purification , Arthritis, Experimental/drug therapy , Capillary Permeability/drug effects , Fever/chemically induced , Fever/prevention & control , Formaldehyde , Gossypium , Granuloma/chemically induced , Granuloma/prevention & control , Male , Mice , Pain/chemically induced , Pain/prevention & control , Plant Epidermis/chemistry , Plant Extracts/chemistry , Plant Extracts/pharmacology , Plant Stems/chemistry , Rats , Rats, Wistar , YeastsABSTRACT
The chloroform extract of nutmeg has been evaluated for antiinflammatory, analgesic and antithrombotic activities in rodents. The extract inhibited the carrageenan-induced rat paw oedema, produced a reduction in writhings induced by acetic acid in mice and offered protection against thrombosis induced by ADP/adrenaline mixture in mice.
