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Org Biomol Chem
; 14(3): 849-52, 2016 Jan 21.
Article
in English
| MEDLINE
| ID: mdl-26647226
ABSTRACT
One of the most successful bioconjugation strategies to date is the copper(I)-catalyzed cycloaddition reaction (CuAAC), however, the typically applied reaction conditions have been found to degrade sensitive biomolecules. Herein, we present a water soluble copper chelator which can be utilized to protect biomolecules from copper induced degradation.