ABSTRACT
A 5-year-old, sexually intact poodle bitch was presented with a 2-year history of inguinal mass. A tentative diagnosis of hydrometra/mucometra with inguinal herniation was made and ovariohysterectomy with hernia repair was performed. Both fluid-filled uterine horns, both broad ligaments, and the uterine body were observed to be herniated through the inguinal ring. On histopathology, marked edema and diffuse hemorrhage were diagnosed in the uterus.
Herniation inguinale avec hydrométrie/mucométrie chez une femelle Caniche. Une femelle Caniche sexuellement intacte âgée de 5 ans a été présentée avec une anamnèse de présence d'une masse inguinale depuis 2 ans. Un diagnostic provisoire d'hydrométrie/mucométrie a été posé et une ovariohystérectomie avec une réparation de l'hernie a été réalisée. Les deux cornes utérines remplies de liquide et les deux ligaments larges ainsi que le corps utérin ont été observés comme ayant herniés par l'anneau inguinal. À l'histopathologie, des Ådèmes marqués et une hémorragie diffuse ont été diagnostiqués dans l'utérus.(Traduit par Isabelle Vallières).
Subject(s)
Dog Diseases/pathology , Hernia, Inguinal/veterinary , Uterine Diseases/veterinary , Animals , Dog Diseases/surgery , Dogs , Female , Hernia, Inguinal/pathology , Hernia, Inguinal/surgery , Uterine Diseases/pathologyABSTRACT
Exogenous estrogens used for therapeutic purposes or endogenous estrogen sources such as functional Sertoli cell or ovarian granulosa cell tumors may cause bone marrow toxicity in dogs. The condition is characterized by hematologic abnormalities including thrombocytopenia, anemia, and leukocytosis or leukopenia. Despite intensive therapy with blood or platelet-rich transfusions, broad-spectrum antibiotics, steroids, and bone marrow stimulants, prognosis is unfavorable. Due to the the risk of stimulating the development of uterine diseases and the potential for inducing aplastic anemia, estrogen use in dogs is best avoided where possible. This paper describes the causes of estrogen-induced myelotoxicity, the clinical presentation of the patients, the diagnosis, and the treatment options in the dog.
Subject(s)
Bone Marrow Diseases/veterinary , Bone Marrow/drug effects , Dog Diseases/chemically induced , Estrogens/adverse effects , Anemia/chemically induced , Anemia/therapy , Anemia/veterinary , Animals , Blood Transfusion/veterinary , Bone Marrow Diseases/chemically induced , Bone Marrow Diseases/therapy , Dog Diseases/therapy , Dogs , Estrogens/therapeutic use , Hemostasis , Leukocytosis/chemically induced , Leukocytosis/therapy , Leukocytosis/veterinary , Leukopenia/chemically induced , Leukopenia/therapy , Leukopenia/veterinary , Prognosis , Thrombocytopenia/chemically induced , Thrombocytopenia/therapy , Thrombocytopenia/veterinaryABSTRACT
A vulvar leiomyosarcoma was diagnosed in an 8-year-old mixed-breed, sexually intact cat. The cat had a history of vulvar swelling, bleeding and stranguria. The mass was located at the ventral commissura of the vulva. The cut surface of the mass was lobulated and greyish-white, with areas of necrosis and haemorrhage. Histologically, it was a spindle-cell sarcoma consisting of interlacing bundles of very elongated neoplastic smooth muscle cells and variably dense collagenous matrix separated by individual cells or streams. It also contained areas of focal necrosis and haemorrhage. The mitotic index ranged from seven to 12 mitoses per 10 high-power fields. Immunohistochemically, the spindle-shaped neoplastic cells were strongly positive for smooth muscle actin (SMA) and vimentin, whereas no immunoreactivity was obtained for desmin. The vascular elements of the internal control tissue also exhibited strong SMA and vimentin immunoreactivity. Based on the morphological and immunohistochemical features, the tumour was classified as a leiomyosarcoma.
