ABSTRACT
Perfusion of the cerebral blood flow in patients with cerebral vascular insufficiency was studied using perfusion computed tomography before and after monotherapy with fraxiparine (single dosage 0.3 ml/2850 ME daily during 20 days) in 20 patients with clinical presentations of this disease in combination with antiphospholipid syndrome and the predominantly distinct hyper production of antiphospholipid antibodies revealed by ELISA. Fraxiparine was administered after the detection of significant changes (not less than 5%) of densitometric parameters characteristic of the state of brain tissue perfusion. Such differences the authors called the signs of "densitometric parameters lateralization". It was shown that the lateralization of X-ray density and its extent, though did not correspond to the severity of clinical presentations of the disease, completely vanished or decreased to the statistically non-significant differences after the treatment. The therapy with fraxiparine significantly increased the blood flow through the brain tissue that was observed in all patients. Thromboprophylactic dosages of fraxiparine improvef the brain microcirculation and reduced the "capillary" hypoxia that correlated with dynamics of neurological disorders specific to the initial signs of chronic brain ischemia.
Subject(s)
Brain Ischemia/diagnostic imaging , Brain Ischemia/drug therapy , Brain/blood supply , Fibrinolytic Agents/therapeutic use , Nadroparin/therapeutic use , Adult , Cerebrovascular Circulation/drug effects , Female , Fibrinolytic Agents/administration & dosage , Humans , Male , Microcirculation/drug effects , Nadroparin/administration & dosage , Perfusion , Tomography, X-Ray ComputedSubject(s)
Hemoperfusion/methods , Parkinson Disease/therapy , Adult , Aged , Antiparkinson Agents/administration & dosage , Combined Modality Therapy , Female , Humans , Male , Middle AgedABSTRACT
Scintigraphic examination of the liver, spleen, bone marrow and retroperitoneal lymph nodes with the help of colloidal radiopharmaceutical 113mIn was conducted in 55 patients with multiple sclerosis (MS) and in 13 patients with other diseases of the nervous system. The authors ascertained dysfunction of cells of the mononuclear phagocytic system (MPS) in the MS patients. Clinical manifestations of the disease were found to correlate with the findings of radionuclide imaging of the parenchymatous organs and lymph nodes. A conclusion was drawn about the total disruption of the functional activity of MPS cells in MS and the inevitable involvement of the liver in the pathogenesis of the disease.
