SmartMedChain: A Blockchain-Based Privacy-Preserving Smart Healthcare Framework.

Nowadays, the adoption of Internet of Things (IoT) technology worldwide is accelerating the digital transformation of healthcare industry. In this context, smart healthcare (s-healthcare) solutions are ensuring better and innovative opportunities for healthcare providers to improve patients' care. However, these solutions raise also new challenges in terms of security and privacy due to the diversity of stakeholders, the centralized data management, and the resulting lack of trustworthiness, accountability, and control. In this paper, we propose an end-to-end Blockchain-based and privacy-preserving framework called SmartMedChain for data sharing in s-healthcare environment. The Blockchain is built on Hyperledger Fabric and stores encrypted health data by using the InterPlanetary File System (IPFS), a distributed data storage solution with high resiliency and scalability. Indeed, compared to other propositions and based on the concept of smart contracts, our solution combines both data access control and data usage auditing measures for both Medical IoT data and Electronic Health Records (EHRs) generated by s-healthcare services. In addition, s-healthcare stakeholders can be held accountable by introducing an innovative Privacy Agreement Management scheme that monitors the execution of the service in respect of patient preferences and in accordance with relevant privacy laws. Security analysis and experimental results show that the proposed SmartMedChain is feasible and efficient for s-healthcare environments.

Molecular recognition between adenine or 2,6-diaminopurine and copper(II) chelates with N,O2,S-tripodal tetradentate chelators having thioether or disulfide donor groups.

Five novel ternary copper(II) complexes with the N,O2,S-tripodal tetradentate chelators N,N-bis(carboxymethyl)-S-benzylcysteaminate(2-) ion (BCBC) or N,N,N',N'-tetrakis(carboxymethyl)cystaminate(4-) ion (TCC) and adenine (Hade), 2,6-diaminopurine (Hdap), 2,2'-bipyridine (bpy) or 1,10-phenanthroline (phen) as co-ligand were synthesized and characterized by X-ray diffraction and other physical methods: [Cu2(BCBC)2(µ2-N3,N7-H(N9)ade)(H2O)2]·H2O (1), [Cu2(BCBC)2(µ2-N7,N9-H(N3)dap)(H2O)2]·4H2O (2), [Cu2(µ2-TCC)(H(N9)ade)2(H2O)2]·10H2O (3), [Cu2(µ2-TCC)(bpy)2]·15H2O (4) and [Cu2(µ2-TCC)(phen)2]·14H2O (5). The crystal structure of H4TCC·3H2O was also determined. All ternary Cu(II) complexes have molecular structures. The N-(2-mercaptoethyl)-iminodiacetate moieties of BCBC or TCC ligands play a NO2+S-tripodal tetradentate role, with the S-(thioether or disulfide) atom as the apical/distal donor of the copper(II) center. In 1-3, the iminodiacetate moiety exhibits a mer-NO2 conformation (two nearly coplanar chelate rings) while in 4 and 5 (with bpy or phen as coligand) it displays a fac-NO+O (apical/distal) conformation. We conclude that the formation of the Cu-S(thioether or disulfide) bonds is strongly favored by the N-branched topology of the S-ligands in the reported compounds.