ABSTRACT
BACKGROUND: Many studies have suggested a strong relation between diet and acne. Many patients with acne believe that spicy and salty foods exacerbate acne. AIM: To assess the relationship between the dietary intake of salty and spicy food and the onset, severity, duration of acne. METHODS: Two hundred patients with acne vulgaris and 200 age- and gender-matched controls were subjected to a detailed questionnaire taking, clinical examination and dietary assessment through using "24 h recall" method. Sodium content of the 24-h food intake was computed by a computer program connecting participants' dietary information to the food composition table of National Nutrition Institute data base. RESULTS: Patients with acne consumed significantly higher daily amounts of sodium chloride (NaCl) (median 3367.54 mg) compared to the controls (median 2271.8 mg) (P < 0.001). A negative correlation between the amount of NaCl in the diet of patients with acne and the age of onset of acne lesions was detected (r = -0.216, P = 0.031). However, neither salty nor spicy food correlated with duration or severity of the disease. CONCLUSION: Consumption of salty foods was significantly higher among patients with acne compared to acne free subjects, making the consumption of salty food a possible participating factor in the development of acne.
Subject(s)
Acne Vulgaris/etiology , Diet/adverse effects , Sodium Chloride/adverse effects , Spices/adverse effects , Acne Vulgaris/physiopathology , Adolescent , Adult , Case-Control Studies , Disease Progression , Female , Humans , Male , Reference Values , Risk Assessment , Young AdultABSTRACT
Kallin syndrome (KS) is a variant of epidermolysis bullosa simplex (EBS), which, in addition to the classic features of EBS, also presents with deafness, alopecia, hypodontia and nail dystrophy. We report the case of a 17-year-old boy who presented to our clinic with trauma-induced skin blistering, alopecia, deafness, dental caries, nail dystrophy and vitiliginous areas. The skin blisters had been appearing since birth, and healed without scarring. The vitiliginous areas were unrelated to the sites of the blisters. Electron microscopy of the skin blisters was diagnostic of EBS, and the depigmented lesions were similar to those of vitiligo. An association of vitiligo with EBS has not been reported previously. Multiple genetic findings have confirmed a role for keratin in regulating skin pigmentation. Apoptosis of melanosome-bearing keratinocytes may participate in the reduction of melanin density and result in depigmentation. Further studies on the defective proteins in KS may clarify the mechanism underlying the association with vitiligo.
Subject(s)
Epidermolysis Bullosa Simplex/pathology , Vitiligo/complications , Adolescent , Alopecia/etiology , Blister/etiology , Deafness/etiology , Epidermolysis Bullosa Simplex/etiology , Humans , Male , Nail Diseases/etiology , SyndromeABSTRACT
BACKGROUND: Nail changes in leprotic patients are not specific to leprosy, and may be observed in other peripheral neuropathies. Diabetes is one of the diseases that present with nail dystrophy secondary to peripheral neuropathy, vasculopathy, trauma and infections. Therefore, nail changes in diabetic neuropathy are expected to be very similar to that of leprosy. OBJECTIVES: To evaluate the frequency and pattern of nail changes in Egyptian leprotic patients with the different spectrums of the disease, and to compare nail changes in leprosy with those seen in patients with diabetic neuropathy. METHODS: The study included 115 leprosy patients and 60 patients with diabetic peripheral neuropathy. Nail examination was thoroughly carried out and various nail changes were recorded including the location of the involved nails (fingers, toes). RESULTS: Our study detected similar incidence of nail changes in both multibacillary (MB) (86%) and paucibacillary (PB) patients (86%). Flag sign (alternating horizontal bands of whitish and pinkish discoloration of the nail) observed in our study was not reported before. It was more commonly seen in MB patients (21%) than in PB patients (14%). Our results also revealed that the nail changes were more commonly seen in leprosy patients (86%) than in diabetic patients (68%). CONCLUSION: Nail changes in leprosy are multifactorial, and could be related to one or more of the following: neuropathy, endarteritis, trauma, drugs or superimposed infections. Nail changes in leprosy may be used as an additional clue that helps in the diagnosis.
Subject(s)
Diabetic Neuropathies/pathology , Leprosy/pathology , Nails/pathology , Adolescent , Adult , Aged , Egypt , Female , Humans , Leprosy/diagnosis , Male , Middle Aged , Nail Diseases/diagnosis , Nail Diseases/pathology , Young AdultSubject(s)
Skin Diseases/pathology , Sweat Gland Diseases/pathology , Child , Eccrine Glands , Humans , Male , MetaplasiaSubject(s)
Allylamine/analogs & derivatives , Antifungal Agents/therapeutic use , Arthrodermataceae , Dermatomycoses/drug therapy , Miconazole/therapeutic use , Adolescent , Adult , Aged , Allylamine/administration & dosage , Allylamine/therapeutic use , Antifungal Agents/administration & dosage , Child , Child, Preschool , Female , Humans , Male , Miconazole/administration & dosage , Middle Aged , OintmentsABSTRACT
Seven patients with xeroderma pigmentosum are presented. Abnormal karyotyping, found in one case, could be associated with an increased risk of the development of neoplasia.
Subject(s)
Skin Neoplasms/genetics , Xeroderma Pigmentosum/genetics , Child , Child, Preschool , Female , Humans , Karyotyping , Male , Pedigree , Skin Neoplasms/pathology , Xeroderma Pigmentosum/pathologyABSTRACT
A combination of both intralesional stibogluconate injection and superficial cryotherapy (not including the base of the lesion nor the 1-2 mm rim of the surrounding normal skin) was performed in an attempt to improve the therapeutic efficacy of either of the two modalities when used separately in the treatment of cutaneous leishmaniasis. This combined therapy resulted in a 100% cure rate in 15 patients with 23 lesions of cutaneous leishmaniasis. Two control groups, one treated with superficial cryo and the other treated with intralesional stibogluconate injection alone were included in the study for evaluation. The results obtained by combined superficial freezing and intralesional stibogluconate injection were much more impressive than those obtained by each of the two modalities when used alone.
Subject(s)
Antimony Sodium Gluconate/therapeutic use , Cryosurgery/methods , Gluconates/therapeutic use , Leishmaniasis/therapy , Adult , Antimony Sodium Gluconate/administration & dosage , Combined Modality Therapy , Drug Administration Schedule , Evaluation Studies as Topic , Female , Humans , Injections, Intralesional , Male , Time FactorsSubject(s)
Allylamine/therapeutic use , Amines/therapeutic use , Clotrimazole/therapeutic use , Dermatomycoses/drug therapy , Imidazoles/therapeutic use , Allylamine/administration & dosage , Allylamine/analogs & derivatives , Clotrimazole/administration & dosage , Double-Blind Method , Humans , Ointments , Time FactorsABSTRACT
Papillon-Lefèvre syndrome is a rare autosomal recessive disorder of palmoplantar keratinization in which there is a unique association of the palmoplantar hyperkeratosis and premature loss of both deciduous and permanent teeth. We report three patients with papillon-lefèvre syndrome who showed a remarkable degree of improvement after treatment with an oral retinoid.
Subject(s)
Etretinate/therapeutic use , Keratoderma, Palmoplantar/drug therapy , Papillon-Lefevre Disease/drug therapy , Administration, Oral , Etretinate/administration & dosage , Etretinate/adverse effects , HumansABSTRACT
Familial melanopathy with giant melanocytes is a unique pigmentary disorder that to the best of the author's knowledge has not been described before. The clinical and pathological features of this disorder, herein described in four patients, are very characteristic and can be easily discerned both grossly and histologically. More patients with this disorder will probably now be recognized, particularly in the Far and Middle East.
