Automatic grading for Arabic short answer questions using optimized deep learning model.

Auto-grading of short answer questions is considered a challenging problem in the processing of natural language. It requires a system to comprehend the free text answers to automatically assign a grade for a student answer compared to one or more model answers. This paper suggests an optimized deep learning model for grading short-answer questions automatically by using various sizes of datasets collected in the Science subject for students in seventh grade in Egypt. The proposed system is a hybrid approach that optimizes a deep learning technique called LSTM (Long Short Term Memory) with a recent optimization algorithm called a Grey Wolf Optimizer (GWO). The GWO is employed to optimize the LSTM by selecting the best dropout and recurrent dropout rates of LSTM hyperparameters rather than manual choice. Using GWO makes the LSTM model more generalized and can also avoid the problem of overfitting in forecasting the students' scores to improve the learning process and save instructors' time and effort. The model's performance is measured in terms of the Root Mean Squared Error (RMSE), the Pearson correlation coefficient, and R-Square. According to the simulation results, the hybrid GWO with the LSTM model ensured the best performance and outperformed the classical LSTM model and other compared models such that it had the highest Pearson correlation coefficient value, the lowest RMSE value, and the best R square value in all experiments, but higher training time than the traditional deep learning model.

The defensive role of taurine against gonadotoxicity and testicular apoptosis effects induced by cisplatin in rats.

INTRODUCTION: Cisplatin (CIS), which is used as a therapeutic antineoplastic agent may produce gonadotoxicity in a process linked to chemotherapy. Taurine, through its potential antioxidant effect, has a protective role against cisplatin-induced oxidative stress and apoptosis. OBJECTIVE: To investigate whether taurine intake can ameliorate testicular damage induced by cisplatin and to study the possible mechanism that mediates this action, either through its antioxidant action alone or in addition to its anti-apoptotic effects. PATIENTS AND METHODS: Fifty healthy adult white male albino rats were randomly distributed into five groups, each involving ten animals. The first group represents the negative control group. The other four groups received three equal doses (3 mg/kg body weight) intraperitoneal injections of cisplatin on alternate days. In the positive control group (group 2), saline only was given. Groups 3, 4 &5 received taurine in distilled water at oral doses of 50, 150, 250 mg/kg, respectively, on alternate days followed by cisplatin (each injection of cisplatin was given 1 day after taurine). On the 28th day after the first dose of normal saline, cisplatin or taurine, blood samples were examined for testosterone levels. All rats were killed and their testes were examined. RESULTS: Rats treated with cisplatin alone showed reduced body weight in addition to reduced testicular weight, impaired sperm counts, and oxidative stress (reduced GSH, increased MDA level), decreased plasma testosterone, apoptotic marker (increased Bax, decreased bcl2). However following taurine induction, the figures for GSH and MDA changed significantly (P < 0.005) referring to the effect of taurine as a potent antioxidant. CONCLUSIONS: Cisplatin-induced germ cell apoptosis may result in decreasing spermatogenesis. However, taurine could effectively prevent nearly all of these cisplatin-induced testicular abnormalities, thereby proving to be an effective cytoprotectant.

Pelvic chondro-sarcoma and erectile dysfunction: A challenging surgical case.

A 46 year-old male presented suffering from refractory erectile dysfunction. The patient had a past history of pelvic chondro-sarcoma. This case was a challenge for us; the surgery performed for excision of the sarcoma has resulted in the elimination of both pubic ramia together with excision of part of both corpora and left hemiscrotum. The procedure included a sling application on one side with a mesh sock wrapped around the rear part of the extendor cylinder. Another sling was applied on the contra lateral side without a mesh sock.