1.
Bioorg Med Chem Lett
; 12(1): 57-60, 2002 Jan 07.
Article
in English
| MEDLINE
| ID: mdl-11738572
ABSTRACT
A new bis-amido-copper(II) complex 2 has been prepared. In the presence of reducing agents (ascorbate or DTT) under air atmosphere or hydrogen peroxide, complex 2 exhibited interesting nuclease activities in the 1-10 microM concentration range. For explaining the activity observed with hydrogen peroxide, we propose the occurrence of a bis-amido-copper(III) intermediate and an oxidation mechanism involving a H-atom abstraction of deoxyribose moieties of DNA.