ABSTRACT
This is a 40-year-old woman with sideroblastic anemia with B cell immunodeficiency, periodic fevers, and developmental delay syndrome, who has genital and extragenital lichen sclerosus on the abdomen and the upper back that have become erythematous and painful during febrile episodes. This report summarizes the published cases of sideroblastic anemia with B cell immunodeficiency, periodic fevers, and developmental delay and highlights associated mucocutaneous features.
Subject(s)
Colitis, Ulcerative/complications , Foot Ulcer/diagnosis , Paronychia/diagnosis , Pyoderma/diagnosis , Stomatitis/diagnosis , Adult , Diagnosis, Differential , Foot Ulcer/etiology , Foot Ulcer/pathology , Humans , Male , Paronychia/etiology , Pyoderma/etiology , Pyoderma/pathology , Stomatitis/etiology , Stomatitis/pathology , Toes/pathology , Wound HealingSubject(s)
Antirheumatic Agents/adverse effects , Arthritis, Rheumatoid/drug therapy , Drug Eruptions/etiology , Methotrexate/adverse effects , Skin Ulcer/chemically induced , Aged , Drug Eruptions/pathology , Female , Humans , Lip/pathology , Skin Ulcer/pathology , Ulcer/chemically induced , Ulcer/pathologyABSTRACT
BACKGROUND: Ulcerative necrobiosis lipoidica (UNL) is an uncommon disease, which is frequently recalcitrant to available therapies. It is characterized by well-defined, ulcerated plaques with indurated borders and atrophic centers. Multiple therapeutic options have been described, with variable success rates. OBJECTIVE: To report the efficacy of using topical tacrolimus in treating UNL. METHOD: Topical tacrolimus was used in the treatment of two patients with UNL. RESULT: Topical tacrolimus is effective in treating UNL. CONCLUSION: Topical tacrolimus is a reasonably effective choice in treating UNL.
Subject(s)
Calcineurin Inhibitors , Immunosuppressive Agents/therapeutic use , Necrobiosis Lipoidica/drug therapy , Tacrolimus/therapeutic use , Administration, Cutaneous , Adult , Aged, 80 and over , Female , Humans , Immunosuppressive Agents/administration & dosage , Necrobiosis Lipoidica/complications , Skin Ulcer/complications , Skin Ulcer/drug therapy , Tacrolimus/administration & dosageSubject(s)
Dermatitis, Allergic Contact/etiology , Dermatitis, Occupational/etiology , Hand Dermatoses/chemically induced , Sulfites/adverse effects , Dermatitis, Allergic Contact/immunology , Dermatitis, Occupational/immunology , Diagnosis, Differential , Hand Dermatoses/immunology , Humans , Patch Tests , Sulfites/immunologyABSTRACT
The enhanced use of exogenous substances for cosmetic and reconstructive procedures is paralleled by an increase in reports of cutaneous adverse reactions to several of these agents. Recognition of the histological features of these reactions is of importance to both dermatologists and dermatopathologists but is not always easy for several reasons. First, cost-related issues are resulting in an increasing number of these procedures being performed overseas. Thus, patients are often unsure about the exact product used. Compounding this is the fact that practitioners who perform these procedures are not forthright in divulging this information, given that improper substances may be admixed in the filler injected. Furthermore, cutaneous reactions may occur at sites distant from injected sites, secondary to migration of the filler substance and a lapse of months to years may occur prior to the development of a cutaneous reaction. Thus, a causal relationship between the procedure and the reaction is often not made. We present an overview of the histological features of adverse reactions to currently available soft tissue fillers, both in the United States and overseas, in an attempt to enhance awareness of the diversity of these reactions.
