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1.
Spinal Cord ; 50(1): 42-50, 2012 Jan.
Article in English | MEDLINE | ID: mdl-21808258

ABSTRACT

BACKGROUND: Disability scales do not enable the transmission of concise, meaningful and daily function description for clinical purposes. STUDY DESIGN: Cross-sectional statistical analysis of 328 patients' Spinal Cord Independence Measure (SCIM) III item scores (SIS). OBJECTIVE: To develop a concise and clinically interpretable data-based characterization of daily task accomplishment for patients with spinal cord lesions (SCLs). SETTING: Multi-center study at 13 spinal units in 6 countries. METHODS: Patients were grouped into clusters characterized by smaller differences between the patients' SIS within the clusters than between their centers, using the k-medoides algorithm. The number of clusters (k) was chosen according to the percent of SIS variation they explained and the clinical distinction between them. RESULTS: Analysis showed that k=8 SIS clusters offer a good description of the patient population. The eight functional clusters were designated as A-H, each cluster (grade) representing a combination of task accomplishments. Higher grades were usually (but not always) associated with patients implementing more difficult tasks. Throughout rehabilitation, the patients' functional grade improved and the distribution of patients with similar functional grades within the total SCIM III score deciles remained stable. CONCLUSIONS: A new classification based on SIS clusters enables a concise description of overall functioning and task accomplishment distribution in patients with SCL. A software tool is used to identify the patients' functional grade. Findings support the stability and utility of the grades for characterizing the patients' functional status.


Subject(s)
Activities of Daily Living/classification , Disability Evaluation , Spinal Cord Injuries/rehabilitation , Adult , Aged , Algorithms , Cross-Sectional Studies , Fecal Incontinence/etiology , Fecal Incontinence/rehabilitation , Female , Humans , Male , Middle Aged , Quadriplegia/etiology , Quadriplegia/rehabilitation , Reproducibility of Results , Retrospective Studies , Spinal Cord Injuries/complications
2.
Spinal Cord ; 49(8): 893-6, 2011 Aug.
Article in English | MEDLINE | ID: mdl-21483443

ABSTRACT

STUDY DESIGN: Multicenter international cohort study. OBJECTIVE: The objective of this study was to establish target values for Spinal Cord Independence Measure (SCIM) III scoring in rehabilitation for clinically complete spinal cord lesion (SCL) neurological levels. SETTING: In total, 13 spinal cord units in six countries from North America, Europe and the Middle East were taken. METHODS: Total SCIM III scores and gain at discharge from rehabilitation were calculated for SCL levels in 128 patients with American Spinal Injury Association Impairment Scale (AIS) grade A on admission to rehabilitation. RESULTS: Median, quartiles, mean and s.d., values of discharge SCIM III scores and SCIM III gain for the various SCL levels are presented. Total SCIM III scores and gain were significantly correlated with the SCL level (r=0.730, r=0.579, P<0.001). CONCLUSIONS: Calculated discharge SCIM III scores can be used as target values for functional achievements at various neurological levels in patients after AIS A SCL. They are generally, but not always, inversely correlated with SCL level.


Subject(s)
Disability Evaluation , Outcome Assessment, Health Care/methods , Spinal Cord Injuries/complications , Spinal Cord Injuries/diagnosis , Adult , Europe , Humans , International Cooperation , Middle Aged , Middle East , Neurologic Examination , North America , Recovery of Function/physiology , Reproducibility of Results , Spinal Cord Injuries/rehabilitation , Young Adult
3.
Spinal Cord ; 49(6): 679-83, 2011 Jun.
Article in English | MEDLINE | ID: mdl-21423254

ABSTRACT

OBJECTIVE: The objective of this study was to describe the projects, the International Spinal Cord Society (ISCoS) has in cooperation with the World Health Organization (WHO) for the benefit of individuals with spinal cord injury (SCI) worldwide. SETTING: International METHODS: Collaboration between ISCoS and WHO can be divided into (A) building capacity for better SCI education and prevention programs; (B) improving classification systems for use of data in SCI research, the International Classification of External Cause of Injury (ICECI), the International Classification of Diseases (ICD) and the International Classification of Functioning, Disability and Health (ICF); and (C) improving the evidence base for SCI through the report, International Perspectives on Spinal Cord Injury (IPSCI). The objectives of the IPSCI report are first to summarize information on SCI, in particular the science and epidemiology, the services, interventions and policies that are relevant and 'the lived experience' of persons with SCI across the full spectrum of life and throughout the world; second, to document all aspects of the science and experience of SCI to identify gaps between what exists and what is required; and third to make recommendations based on this evidence, with a clear perception of feasible goals and targets, that are consistent with the aspirations and goals of inclusion and full participation as expressed in the UN Convention of the Rights of Persons with Disabilities. FUTURE COOPERATION: ISCoS and WHO will continue to join forces in areas where they can make the greatest difference, especially in prevention and educational issues worldwide.


Subject(s)
International Cooperation/legislation & jurisprudence , Societies, Medical/organization & administration , Spinal Cord Injuries/therapy , World Health Organization/organization & administration , Cooperative Behavior , Humans , Patient Education as Topic/standards , Patient Education as Topic/trends , Societies, Medical/trends , Spinal Cord Injuries/diagnosis , Spinal Cord Injuries/prevention & control
4.
Spinal Cord ; 49(2): 292-6, 2011 Feb.
Article in English | MEDLINE | ID: mdl-20820178

ABSTRACT

STUDY DESIGN: A multi-center international cohort study. OBJECTIVE: To evaluate the reliability and validity of the third version of the Spinal Cord Independence Measure (SCIM III), separately for patients with traumatic spinal cord lesions (SCLs). SETTING: A total of 13 spinal cord units in six countries from North America, Europe and the Middle-East. METHODS: SCIM III and Functional Independence Measure (FIM) were assessed for 261 patients with traumatic SCLs, on admission to rehabilitation and before discharge, by two raters. Conventional statistical measures were used to evaluate the SCIM III reliability and validity. RESULTS: In almost all SCIM III tasks, the total agreement between the paired raters was >80%. The κ coefficients were all >0.6 and statistically significant. Pearson's coefficients of the correlations between the paired raters were >0.9, the mean differences between raters were nonsignificant and the intraclass correlation coefficients (ICCs) were ≥ 0.95. Cronbach's α values for the entire SCIM III scale were 0.833-0.835. FIM and SCIM III total scores were correlated (r=0.84, P<0.001). SCIM III was more responsive to changes than FIM. In all subscales, SCIM III identified more changes in function than FIM, and in 3 of the 4 subscales, differences in responsiveness were statistically significant (P<0.02). CONCLUSION: The results confirm the reliability and validity of SCIM III for patients with traumatic SCLs in a number of countries.


Subject(s)
Disability Evaluation , Outcome Assessment, Health Care/methods , Spinal Cord Injuries/diagnosis , Spinal Cord Injuries/rehabilitation , Surveys and Questionnaires/standards , Activities of Daily Living/classification , Adult , Cohort Studies , Female , Humans , Independent Living/standards , Male , Middle Aged , Young Adult
5.
Disabil Rehabil ; 29(24): 1926-33, 2007 Dec 30.
Article in English | MEDLINE | ID: mdl-17852230

ABSTRACT

PURPOSE: To examine the third version of the Spinal Cord Independence Measure (SCIM III) for reliability and validity in a multi-center cohort study. METHOD: Four hundred and twenty-five patients with spinal cord lesions from 13 spinal cord units in six countries from three continents were assessed with SCIM III and the Functional Independence measure (FIM) on admission to rehabilitation and before discharge. RESULTS: Total agreement between raters was above 80% in most SCIM III tasks, and all kappa coefficients were statistically significant (P<0.001). The coefficients of Pearson correlation between the paired raters were above 0.9, and intraclass correlation coefficients were above 0.94. Cronbach's alpha was above 0.7. The coefficient of Pearson correlation between FIM and SCIM III was 0.790 (P<0.01). SCIM III was more responsive to changes than FIM in the subscales of Respiration and sphincter management and Mobility indoors and outdoors. CONCLUSIONS: The results support the reliability and validity of SCIM III in a multi-cultural setup. Despite several limitations of the study, the results indicate that SCIM III is an efficient measure for functional assessment of SCL patients and can be safely used for clinical and research trials, including international multi-center studies.


Subject(s)
Disability Evaluation , Spinal Cord Diseases/rehabilitation , Activities of Daily Living , Cohort Studies , Defecation , Female , Humans , Male , Middle Aged , Mobility Limitation , Paraplegia/rehabilitation , Quadriplegia/rehabilitation , Reproducibility of Results , Respiration , Self Care , Urination
6.
Spinal Cord ; 45(4): 275-91, 2007 Apr.
Article in English | MEDLINE | ID: mdl-16909143

ABSTRACT

BACKGROUND: A third version of the Spinal Cord Independence Measure (SCIM III), made up of three subscales, was formulated following comments by experts from several countries and Rasch analysis performed on the previous version. OBJECTIVE: To examine the validity, reliability, and usefulness of SCIM III using Rasch analysis. DESIGN: Multicenter cohort study. SETTING: Thirteen spinal cord units in six countries from North America, Europe, and the Middle-East. SUBJECTS: 425 patients with spinal cord lesions (SCL). INTERVENTIONS: SCIM III assessments by professional staff members. Rasch analysis of admission scores. MAIN OUTCOME MEASURES: SCIM III subscale match between the distribution of item difficulty grades and the patient ability measurements; reliability of patient ability measures; fit of data to Rasch model requirements; unidimensionality of each subscale; hierarchical ordering of categories within items; differential item functioning across classes of patients and across countries. RESULTS: Results supported the compatibility of the SCIM subscales with the stringent Rasch requirements. Average infit mean-square indices were 0.79-1.06; statistically distinct strata of abilities were 3 to 4; most thresholds between adjacent categories were properly ordered; item hierarchy was stable across most of the clinical subgroups and across countries. In a few items, however, misfit or category threshold disordering were found. CONCLUSIONS: The scores of each SCIM III subscale appear as a reliable and useful quantitative representation of a specific construct of independence after SCL. This justifies the use of SCIM in clinical research, including cross-cultural trials. The results also suggest that there is merit in further refining the scale.


Subject(s)
Disability Evaluation , Psychometrics/methods , Spinal Cord Injuries/physiopathology , Activities of Daily Living , Adult , Cohort Studies , Female , Health Status Indicators , Humans , Male , Middle Aged , Models, Statistical , Reproducibility of Results , Software , Surveys and Questionnaires
7.
Spinal Cord ; 43(10): 573-6, 2005 Oct.
Article in English | MEDLINE | ID: mdl-16158073

ABSTRACT

STUDY DESIGN: Reviewing documents about Lord Admiral Nelson's wound inflicted at the Battle of Trafalgar and studying the collected data in connection with ballistics and human anatomy. OBJECTIVES: Attempting to find out the actual cause of death of Lord Nelson as soon as 4 h postinjury by a musket ball. SETTING: United Kingdom. METHODS: (1) Review of the original report of Mr W Beatty, Lord Nelson's surgeon, on his examination of His Lordship's wound. (2) Investigating the course of the musket ball in connection with an atlas of human anatomy. (3) Investigating the course of the musket ball on a cadaver by RP (one of the authors). (4) Reviewing modern medical literature. RESULTS: The report of Mr Beatty suggested that division of a large branch of the pulmonary artery was the cause of Lord Nelson's early death. Assuming the left pulmonary artery was injured, anatomical studies based on atlases and dissection on a cadaver failed to support a simple straight-line course of the musket ball that could have divided the artery and damage the spinal cord on its path forward. CONCLUSION: The question remains open as to how the musket ball following a relatively straight-line trajectory by entering the body at the acromion, could have divided the left pulmonary artery and damaged the spinal cord later in its course. The mechanism needs further investigation.


Subject(s)
Blood Vessels/injuries , Cause of Death , Nervous System Diseases/pathology , England , Famous Persons , History, 18th Century , History, 19th Century , Humans , Male , Nervous System Diseases/history
8.
Spinal Cord ; 40(8): 388-95, 2002 Aug.
Article in English | MEDLINE | ID: mdl-12124665

ABSTRACT

A case of extensive heterotopic ossification involving the left hip in a 16 year old girl who sustained non traumatic spinal paralysis at T4 ASIA scale A. This case demonstrates the practical difficulties facing clinicians involved in the rehabilitation of this paraplegic patient who required intervention before full maturation of her left hip heterotopic ossification (HO). The patient was developing a rapidly progressive fixed scoliosis and severe difficulty in achieving a proper seating posture. In addition there was difficulty with the application of a suitable orthosis to try and limit the progression of scoliosis as a result of the HO. Discussants will comment on heterotopic ossification in general and the course of action in this particular case.


Subject(s)
Hip/physiopathology , Ossification, Heterotopic/complications , Ossification, Heterotopic/therapy , Paraplegia/therapy , Spinal Cord Injuries/complications , Adolescent , Etidronic Acid/therapeutic use , Female , Humans , Ossification, Heterotopic/diagnostic imaging , Paraplegia/complications , Radiography , Scoliosis/etiology , Thigh/physiopathology , Thoracic Vertebrae
9.
Spinal Cord ; 39(9): 492-7, 2001 Sep.
Article in English | MEDLINE | ID: mdl-11571662

ABSTRACT

This is a case report describing an injury--sustained by a 25-year-old man during a car accident, and characterized by fracture dislocation of the spine at the level of C7 and T4 accompanied by pulmonary contusion. He had an incomplete spinal cord lesion at the level of C7 and a complete lesion at the level of T4 (T4 ASIA A). Imaging of the spine showed three column fractures with ventral spinal cord compression at both levels. Discussants of this case comment on the concept of acute treatment of severe double spinal cord injuries, and present their chosen way of management in this particular case.


Subject(s)
Fracture Fixation, Internal/methods , Spinal Fractures/surgery , Accidents, Traffic , Adult , Cervical Vertebrae/injuries , Cervical Vertebrae/surgery , Humans , Male , Recovery of Function , Spinal Fractures/diagnosis , Spinal Fractures/etiology , Thoracic Vertebrae/injuries , Thoracic Vertebrae/surgery
10.
Spinal Cord ; 38(5): 273-86, 2000 May.
Article in English | MEDLINE | ID: mdl-10822400

ABSTRACT

STUDY DESIGN: Systematic literature review for primary data using predefined inclusion, exclusion and validity criteria. Primary outcome measure was standardised neurological examination or neurological function. Secondary outcomes; acute mortality, early morbidity. OBJECTIVES: To access the literature available to clinicians systematically and evaluate the evidence for an effect of high dose methylprednisolone (MPSS) on neurological improvement following acute spinal cord injury (ACSI). METHODS: Information retrieval was based on Medline search (1966 through December 1999) using the strategy 'spinal cord injury' and 'methylprednisolone' (or 'dexamethasone') with no other restrictions. Primary data publications using high dose steroids given within 12 h following spinal cord injury and reporting outcome measures separately for steroid and non-steroid treated groups were selected. Evaluation followed the guides of Guyatt et al7 (for the Evidence Based Working Group in Canada). Studies with questionable validity were excluded. Level of evidence and treatment recommendation utilised the Canadian Task Force on the Periodic Health Examination criteria.6 Experimental spinal cord injury studies on larger animals were included; small mammal experiments were considered beyond evaluation. RESULTS: Three clinical trials and six cohort study publications were found to satisfy the review criteria. The evidence they provide supports 'the recommendation that the manoeuvre (high dose methylpredisolone) be excluded from consideration as an intervention for the condition'10 (acute spinal cord injury). Twelve larger animal publications were detailed. Validity and the functional significance of results was of concern in many. The weight of evidence lay with those studies demonstrating no definite effect of MPSS on functional outcome. In cat experiments with higher level cord damage, deaths in the MPSS treated groups were notable. CONCLUSION: The evidence produced by this systematic review does not support the use of high dose methylprednisolone in acute spinal cord injury to improve neurological recovery. A deleterious effect on early mortality and morbidity cannot be excluded by this evidence.


Subject(s)
Methylprednisolone/administration & dosage , Spinal Cord Injuries/drug therapy , Acute Disease , Animals , Clinical Trials as Topic , Cohort Studies , Dose-Response Relationship, Drug , Humans , Methylprednisolone/therapeutic use
11.
Spinal Cord ; 37(9): 617-23, 1999 Sep.
Article in English | MEDLINE | ID: mdl-10490852

ABSTRACT

A 30-year-old healthy woman was involved in a road traffic accident. She sustained a fracture dislocation of T11/12 with a complete Frankel A paraplegia below T11. She had no associated injuries. High Dose Methylprednisolone was administered according to the NASCIS III protocol (48 h) together with low molecular weight Heparin and gastroprotected medication. Complete transection of the spinal cord and an anterior haematoma from T11 to T12 were confirmed on X rays, CT's and MRI scans. Posterior surgical stabilisation was performed using Isola instrumentation, starting 8 h post injury. Her post surgical period was uneventful except for some episodes of low blood pressure (85/60 mmHg) from which she had no symptoms. On the 12th post operative day, while in the physiotherapy department, she complained of right scapular pain. This occurred every time she was sat up and was associated with paraesthesia of both upper limbs. Two days later she deteriorated neurologically and her level ascended initially to T8 and then to T3. MRI of the spine with and without gadolinium showed spinal cord oedema between C3 and T1. There was no evidence of haemorrhage or syringomyelia. The authors discussed this case making different hypotheses. They are mainly the following: (1) Gradually ascending ischaemia due to a vascular disorder; (2) Double spinal trauma; (3) Ischaemia related to repeated hypotensive episodes; (4) Low grade intramedullary tumour; and (5) Thrombus of the Radicularis Magna artery. The case has been recognised as being very rare and interesting. In the conclusions, the presenting author stresses the importance of adopting MRI-compatible instrumentation for the surgical stabilisation of the spine, and careful monitoring of blood pressure during the acute phase of spinal cord injury. Dr Aito agrees with Mr El Masry about the opportunity of forming a group of clinicians in order to discuss protocols to cope with this devastating complication.


Subject(s)
Spinal Cord Injuries/pathology , Spinal Cord/pathology , Adult , Anti-Inflammatory Agents/therapeutic use , Female , Humans , Magnetic Resonance Imaging , Methylprednisolone/therapeutic use , Spinal Cord/diagnostic imaging , Spinal Cord Injuries/diagnostic imaging , Spinal Cord Injuries/drug therapy , Tomography, X-Ray Computed
13.
Ann Neurol ; 46(1): 15-21, 1999 Jul.
Article in English | MEDLINE | ID: mdl-10401776

ABSTRACT

Erectile dysfunction is a common complication of spinal cord injury. This double-blind, placebo-controlled, two-way crossover study assessed the efficacy and safety of oral sildenafil in men with erectile dysfunction caused by traumatic spinal cord injury. A total of 178 men (mean age, 38 years) received placebo or sildenafil 1 hour before sexual activity for 6 weeks; after a 2-week washout period, the men received the alternate treatment for 6 weeks. The 50-mg starting dose could be adjusted to 100 or 25 mg based on efficacy and tolerability. Efficacy was assessed by using global efficacy questions, the International Index of Erectile Function (IIEF), and a patient log of erectile activity. Of 143 men with residual erectile function at baseline, 111 (78%) reported improved erections and preferred sildenafil to placebo. For all men (including those who reported no residual erectile function at baseline), 127 of 168 (76%) reported improved erections and preferred sildenafil to placebo. For all men, 132 of 166 (80%) reported that sildenafil improved sexual intercourse compared with 17 of 166 men (10%) reporting improvement with placebo. IIEF questions assessing the ability to achieve and maintain erections and satisfaction with sexual intercourse demonstrated significant improvement with sildenafil. Sildenafil was well tolerated, with a low rate of discontinuation because of treatment-related adverse events (2% vs 1% for placebo). Oral sildenafil is an effective and well-tolerated treatment for erectile dysfunction caused by spinal cord injury.


Subject(s)
Erectile Dysfunction/drug therapy , Phosphodiesterase Inhibitors/therapeutic use , Piperazines/therapeutic use , Spinal Cord Injuries/complications , Administration, Oral , Cross-Over Studies , Double-Blind Method , Erectile Dysfunction/etiology , Humans , Male , Phosphodiesterase Inhibitors/administration & dosage , Phosphodiesterase Inhibitors/adverse effects , Piperazines/administration & dosage , Piperazines/adverse effects , Purines , Sildenafil Citrate , Sulfones
16.
Spinal Cord ; 36(2): 110-6, 1998 Feb.
Article in English | MEDLINE | ID: mdl-9495001

ABSTRACT

Paraplegia is one of the major complications following repair of aortic aneurysms or congenital malformations and from trauma of the aorta. In a series of 12 surviving patients we describe the clinical features as well as the evolution and pathophysiology of ischaemic lesions of the spinal cord. The clinical characteristics: loss of tendon reflexes, preservation of light touch sensation and bladder function, and the special topography of pin prick impairment, suggest involvement of the central grey matter. This lesion of the grey matter is incomplete in most of the patients and tends to extend for 2-10 segments. In some cases it can extend downward to the conus resulting in complete flaccid paraplegia. On follow-up we have observed limited improvement in most cases. No patient has recovered fully. Except in cases of traumatic laceration, where symptoms existed before surgery, paraplegia followed surgical repair in all other cases. Ischaemia can be related to the duration and the site of crossclamping of the aorta. Clamping above the left subclavian artery and/or a ligation of the intercostal arteries without previous visualisation of the spinal cord arteries can be dangerous. Other factors such as the phenomena of revascularisation and the presence of free radicals are discussed. These could explain delayed postischaemic spinal cord hypoperfusion.


Subject(s)
Aorta/injuries , Aorta/surgery , Postoperative Complications/physiopathology , Spinal Cord Diseases/etiology , Spinal Cord Diseases/physiopathology , Adolescent , Adult , Aged , Aorta/abnormalities , Aortic Aneurysm/surgery , Female , Humans , Male , Middle Aged , Regional Blood Flow/physiology , Spinal Cord/blood supply
18.
Injury ; 28(3): 215-7, 1997 Apr.
Article in English | MEDLINE | ID: mdl-9274741

ABSTRACT

We reviewed 95 consecutive patients with cervical spinal cord injury admitted within 2 days of injury and treated nonoperatively, to elucidate the relationship between neurological deterioration and the white blood cell count in the first 4 days after injury. The count for 14 patients who had neurological deterioration was 13.2 +/- 3.2 x 10(9)/l, and that for 81 patients who had no deterioration was 11.0 +/- 3.1 x 10(9)/l. None of 19 patients whose highest white blood cell count was less than 9 x 10(9)l deteriorated, while 14 of 76 patients whose count was 9 x 10(9)/l or more deteriorated. These results suggest that the white blood cell is important in the secondary pathological changes after mechanical injury to the spinal cord.


Subject(s)
Leukocyte Count , Spinal Cord Diseases/etiology , Spinal Cord Injuries/blood , Adult , Female , Humans , Male , Middle Aged , Nervous System Diseases/blood , Nervous System Diseases/etiology , Retrospective Studies , Spinal Cord Diseases/blood , Spinal Cord Injuries/pathology , Time Factors
19.
Spinal Cord ; 35(3): 147-50, 1997 Mar.
Article in English | MEDLINE | ID: mdl-9076864

ABSTRACT

The aim of this study was to determine the benefits of patients admitted early to the specialist spinal injuries centre. The results show a significant reduction in the incidence of pressure sores in the early admitted patients and demonstrate the lowered incidence of both preventable and non preventable complications, as well as reduction of hospitalisation time.


Subject(s)
Spinal Cord Injuries/rehabilitation , Adult , Female , Humans , Length of Stay , Male , Paraplegia/epidemiology , Paraplegia/mortality , Paraplegia/rehabilitation , Quadriplegia/epidemiology , Quadriplegia/mortality , Quadriplegia/rehabilitation , Spinal Cord Injuries/epidemiology , Spinal Cord Injuries/mortality , Time Factors , United Kingdom/epidemiology
20.
Curr Opin Neurol ; 10(6): 484-92, 1997 Dec.
Article in English | MEDLINE | ID: mdl-9490147

ABSTRACT

Spinal cord injuries and their catastrophic effects require a treatment infrastructure able to provide an integrated process of management, including rehabilitation from injury and on an ongoing basis. This is particularly important because the incidence of spinal cord injuries is small. Better outcomes and cost efficiency with such an infrastructure have been established, but further knowledge is required to solve the remaining controversies in some aspects of management.


Subject(s)
Spinal Cord Injuries/rehabilitation , Humans , Spinal Cord Injuries/drug therapy , Spinal Cord Injuries/physiopathology , Treatment Outcome
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