ABSTRACT
In this study, diabetes was induced by intravenous injection of dithizone. In dithizonised diabetic animals, the levels of serum zinc, iron, and potassium were found to be higher than normal, while those of serum calcium and sodium were lower. Copper and magnesium levels were unchanged. After treatment with insulin, most of these serum levels approached the normal, except for serum potassium and magnesium.
Subject(s)
Diabetes Mellitus/blood , Minerals/blood , Animals , Blood Glucose/analysis , Calcium/blood , Copper/blood , Diabetes Mellitus/chemically induced , Diabetes Mellitus/drug therapy , Dithizone , Insulin/therapeutic use , Iron/blood , Potassium/blood , Rats , Sodium/blood , Zinc/bloodABSTRACT
The effect of carbon disulphide intoxication on amino acid pattern was studied. Five groups of rats were treated with carbon disulphide through intramuscular injection of 0.05 ml CS2 in 0.2 mg olive oil/rat/day. A number of rats were sacrificed after receiving 10, 20, 30, 40, and 50 injections. As a result of intoxication, a state of hypoaminoacidemia and hyperaminoacidurea affected all the amino acids investigated, but to variable extent. Of value to add that stoppage of carbon disulphide leads to improvement of the amino-acid pattern in group six, compared to the other groups.
