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Intercalating nucleic acids: the influence of linker length and intercalator type on their duplex stabilities.
Christensen, Ulf B; Wamberg, Michael; El-Essawy, Farag A G; Ismail, Abd El-Hamid; Nielsen, Christina B; Filichev, Vyacheslav V; Jessen, Carsten H; Petersen, Michael; Pedersen, Erik B.
Nucleosides Nucleotides Nucleic Acids ; 23(1-2): 207-25, 2004.
Article in English | MEDLINE | ID: mdl-15043148

ABSTRACT

Six new examples of intercalating nucleic acids were synthesized in order to evaluate the dependence of the length of the linker between oligo and intercalator on the thermal stability of their corresponding duplexes and triplexes.


Subject(s)
Intercalating Agents/metabolism , Nucleic Acids/metabolism , Hot Temperature , Intercalating Agents/chemistry , Magnetic Resonance Spectroscopy , Models, Molecular
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