ABSTRACT
New binuclear Co(II) (1), Ni(II) (2) and Cu(II) (3) complexes of N,N'-(2,2'-azanediylbis(ethane-2,1-diyl))bis(2-aminobenzamide) have been synthesized and fully characterized by various chemical and spectral techniques. The synthesized complexes were irradiated by 60Co gamma rays to dose value of 100 kGy (hereafter referred to as 1a,2a,3a). Molar conductance, spectral, thermal, magnetic moment measurements, powder X-ray diffraction and solid electrical conductivity measurements were investigated before and after exposure to irradiation. The results showed that the current complexes slightly affected by the applied irradiation dose and that, the thermal decomposition proï¬les of non-irradiated and irradiated samples were changed upon irradiation. From powder X-ray diffraction the crystallite size as well as dislocation density were slightly changed. Surface morpholgical changes were observed for [Cu2LCl2(OH)2(H2O)]·2H2O (3) upon irradiation. Irradiation resulted in change in d.c solid electrical conductivity this change was, however, more pronounced for samples 2a,3a.
ABSTRACT
Novel tetraamidemacrocyclic 15-membered ligand [L] i.e. naphthyl-dibenzo[1,5,9,12]tetraazacyclopentadecine-6,10,11,15-tetraoneand its transition metal complexes with Fe(II), Co(II), Ni(II), Cu(II), Ru(III) and Pd(II) have been synthesized and characterized by elemental analysis, spectral, thermal as well as magnetic and molar conductivity measurements. On the basis of analytical, spectral (IR, MS, UV-Vis, (1)H NMR and EPR) and thermal studies distorted octahedral or square planar geometry has been proposed for the complexes. The antitumor activity of the synthesized ligand and some complexes against human breast cancer cell lines (MCF-7) and human hepatocarcinoma cell lines (HepG2) has been studied. The complexes (IC50=2.27-2.7, 8.33-31.1µg/mL, respectively) showed potent antitumor activity, towards the former cell lines comparable with their ligand (IC50=13, 26µg/mL, respectively). The results show that the activity of the ligand towards breast cancer cell line becomes more pronounced and significant when coordinated to the metal ion.
