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1.
J Prim Care Community Health ; 14: 21501319231162480, 2023.
Article in English | MEDLINE | ID: mdl-36974347

ABSTRACT

There have only been limited studies that have assessed the attitude of Canadian physicians toward their own physical health. The aim of our study was to explore the self-reported health maintenance behavior and the predictors of health practices among physicians in a small-medium sized Canadian community. We used a descriptive mailed in self-report survey to contact all 649 physicians registered with the Essex County Medical Society, with a 36% response rate. Our results showed that 81% of physicians in Windsor-Essex County were satisfied with how well they care for themselves, despite reporting low levels of physical activity and a lower percentage of respondents having family physicians than the general population. Five independent factors were identified with physician self-perceived health satisfaction: Physician age of 45 to 54 (95% CI 0.17-0.92; OR 0.39), graduating from Canadian medical schools (95% CI 0.15 to 0.80; OR 0.35), having more than one co-morbidity (95% CI 0.13-0.72; OR 0.31), physicians who had a regular family doctor (95% CI 1.12-5.52; OR 2.43), and engagement in regular moderate weekly exercise (95% CI 1.05-4.94; OR 2.28). We also contrasted the preventive health screening markers of our study to compliance rates of the general population as well as the national physician study. Our results showed that screening rates among our study physician group differed markedly from the general population. For colorectal and breast cancers, physicians in our study reported screening rates of 77.8% and 37.3% respectively, compared with the general population, who's screening rates are 32.3% and 72.5%. Future studies exploring specific targeted health promotion interventions that could address these factors may be warranted in order to further improve Canadian physician health, and ultimately improve their ability to take care of their patients.


Subject(s)
Breast Neoplasms , Physicians, Family , Humans , Female , Self Report , Canada/epidemiology , Surveys and Questionnaires , Practice Patterns, Physicians'
3.
Article in English | MEDLINE | ID: mdl-34162757

ABSTRACT

BACKGROUND AND PURPOSE: Chronic illness is a complex condition that affects over one billion people. To develop a deeper insight of the needs of this patient population, interpretive description uses disciplinary knowledge as the source of understanding. This methodology is a pragmatic approach to research without focusing on a strict methodological directive. The aims of this scoping review are twofold, (a) to describe the findings of studies that have used Thorne's interpretive description to research chronic illness and (b) to discuss the application of interpretive description in clinical research. Thereby, showing interpretive description as a valuable tool to advance nursing knowledge and patient care. METHODS: The methodological framework for this review was based on the Johanna Briggs Institute guidelines for scoping reviews. RESULTS: To develop an understanding of interpretive description, it is essential to examine the results of studies which have applied the methodology. Our scoping review showed that researchers utilizing interpretive description identified four common challenges experienced by individuals living with chronic illness: symptom management, education and knowledge, supportive care, and cultural disadvantages. By demonstrating how interpretive description is applied, it shows how it can be used to understand and interpret clinical phenomena to improve practice. IMPLICATION FOR PRACTICE: This scoping review demonstrates how interpretive description was used to develop knowledge about chronic illness. The premise of interpretive description is that disciplinary knowledge offers a sufficient foundation to develop meaningful research to support health practices. By approaching research from a disciplinary perspective, new knowledge can be discovered to complex health problems.

4.
Geriatr Nurs ; 42(4): 816-824, 2021.
Article in English | MEDLINE | ID: mdl-34090225

ABSTRACT

OBJECTIVE: The aim of this study is to report the findings of meta-synthesis of the experiences and perceptions of person-centered care among nurses and nurse aides in long term care facilities to help managers and policy makers in providing and improving health services. METHODS: This is a meta-synthesis of qualitative studies guided by seven steps process of meta-ethnography developed by Noblit and Hare. Systematic literature searching was conducted in CINAHL, MEDLINE, Web of Science, PubMed, PsycINFO, Scopus, Cochrane library and ProQuest dissertations databases. We assessed quality of the studies using Critical Appraisal Skills Program tool. RESULTS: Eleven studies and one dissertation were identified as relevant for the review. The analysis of this systematic review was resulted in three categories: Recognizing resident's emotional needs and preferences under the task-based workload; holistic understanding to build relationship and participation; teamwork, being recognized and ongoing training to overcome the challenges. CONCLUSION: The concept of PCC in direct care level is perceived well with majority of the study participants but the reality between perceived and practicing PCC is different which indicates mostly lack of organizational rearrangements and support.


Subject(s)
Nurses , Nursing Assistants , Humans , Patient-Centered Care , Perception , Qualitative Research
5.
Can Med Educ J ; 12(1): e46-e59, 2021 Feb.
Article in English | MEDLINE | ID: mdl-33680230

ABSTRACT

BACKGROUND: Regional medical campuses (RMC) have shown promise in addressing physician shortages. RMCs have been positively evaluated in rural/remote communities, however, it is unclear whether this model will be as beneficial in underserved urban areas. This study evaluated the impact of a RMC on a midsized urban city (Windsor, Ontario). We compare our results with a similar study conducted in a remote community in British Columbia (BC). METHODS: A broad array of community stakeholders representing different sectors were consulted using a semi-structured interview format replicated from the BC Northern Medical Program (NMP) study. Thematic analysis based on the resulting rich data was conducted within a grounded theory context. RESULTS: Twenty-three participants (52% male) representing healthcare, education, business, community and government/politico sectors were consulted. Their views regarding the Windsor Regional Medical Campus (WRMC) aligned around several themes: improved healthcare, enhanced community reputation, stimulated economic/community development, expanded training opportunities and an engaged community regarding the WRMC. These results were compared to the main findings of the NMP study with both similarities (e.g. increased community pride) and differences (e.g. resource concerns) discussed. CONCLUSION: Community stakeholders provided strong support for the WRMC through their perceptions of its positive impact on this urban region. These findings are consistent with similar RMC studies in rural/remote areas. Those interested in developing a RMC might benefit from considering these findings.


CONTEXTE: Les campus cliniques régionaux (CCR) se sont révélés prometteurs pour remédier à la pénurie de médecins. Les CCR ont été évalués positivement dans les collectivités rurales/éloignées, mais il n'est pas certain que ce modèle soit aussi bénéfique dans les zones urbaines mal desservies. La présente étude évalue l'impact d'un CCR dans une ville de taille moyenne (Windsor, Ontario). Nous comparons nos résultats avec ceux d'une étude similaire menée dans une collectivité éloignée en Colombie-Britannique (BC). MÉTHODE: Un large éventail de parties prenantes de la collectivité représentant différents secteurs a été consulté par le biais d'entrevues semi-structurées calquées sur celles de l'étude du BC Northern Medical Program (NMP). L'analyse thématique des riches données obtenues a été faite selon l'approche de la Grounded Theory (théorie ancrée). RÉSULTATS: Vingt-trois participants (52 % d'hommes) des secteurs de la santé, de l'éducation, des affaires, de la vie communautaire, du gouvernement ou encore du monde politique ont été consultés. Leurs opinions concernant le campus clinique régional de Windsor (WRMC) s'articulaient autour de plusieurs thèmes : l'amélioration des soins de santé, le renforcement de la réputation de la collectivité, la stimulation du développement économique et communautaire, l'élargissement des possibilités de formation et l'engagement de la communauté envers le WRMC. Les résultats ont été comparés aux principales conclusions de l'étude du NMP, en analysant aussi bien les similitudes (par exemple, fierté accrue de la collectivité) que les différences (par exemple, les préoccupations en matière de ressources). CONCLUSION: Percevant l'impact positif qu'a eu le WRMC dans la région urbaine, les acteurs de la collectivité témoignent d'un ferme appui à son égard. Ces résultats sont conformes aux études similaires portant sur des CCR dans les zones rurales/éloignées. Les résultats de l'étude seraient utiles à tous ceux qui souhaitant mettre sur pied un CCR.

6.
Clin Nephrol ; 95(4): 189-194, 2021 Apr.
Article in English | MEDLINE | ID: mdl-33433318

ABSTRACT

BACKGROUND: Intravenous iron is one of the main therapies for anemia management in hemodialysis-dependent patients. Data comparing the efficacy of ferumoxytol versus other parenteral iron supplements are scarce. The objective of the study was to compare the efficacy of ferumoxytol with that of sodium ferric gluconate in outpatient hemodialysis patients. MATERIALS AND METHODS: A prospective, observational study was conducted in outpatients receiving ferumoxytol 510 mg once or twice quarterly compared to sodium ferric gluconate 125 mg weekly in a single center hemodialysis center in Ontario, Canada. Patient demographics, hemoglobin levels, iron indices, iron doses, and erythropoiesis-stimulating agent (ESA) doses were collected. RESULTS: The study sample consisted of 291 observations from 173 patients. Generalized estimating equations of multiple linear regression modeling were conducted to compare the outcomes while adjusting for baseline scores. Approximately 25% of the study participants received ferumoxytol while 75% received sodium ferric gluconate. Patients treated were mainly males (58.4%), and the mean age was 68.73 (SD ± 13.03) years. Both groups did not show significant differences in their hemoglobin levels (Wald z = 0.54; p = 0.46), ESA utilization at 3 months (Wald z = 0.20; p = 0.65), and TSAT levels (Wald z = 3.45; p = 0.06). However, the iron levels (Wald z = 4.24; p = 0.04) and ferritin levels (Wald z = 5.14; p = 0.02) were higher in the ferric gluconate group (Wald z = 58.78; p ≤ 0.001), and patients who received ferumoxytol received more blood transfusions as compared to those who received sodium ferric gluconate (χ2 = 16.71; p ≤ 0.001). CONCLUSION: Both iron products maintained hemoglobin levels, but patients receiving ferumoxytol had lower iron indices and received more blood transfusions compared to patients who received sodium ferric gluconate.


Subject(s)
Anemia , Ferric Compounds , Ferrosoferric Oxide , Renal Dialysis/adverse effects , Aged , Aged, 80 and over , Anemia/drug therapy , Anemia/etiology , Blood Transfusion/statistics & numerical data , Female , Ferric Compounds/administration & dosage , Ferric Compounds/therapeutic use , Ferrosoferric Oxide/administration & dosage , Ferrosoferric Oxide/therapeutic use , Hemoglobins/analysis , Humans , Male , Middle Aged , Prospective Studies , Treatment Outcome
7.
Can J Nurs Res ; 53(3): 316-321, 2021 Sep.
Article in English | MEDLINE | ID: mdl-32522115

ABSTRACT

The presence of statistical outliers is a shared concern in research. If ignored or improperly handled, outliers have the potential to distort parameter estimates and possibly compromise the validity of research findings. The purpose of this paper is to provide a conceptual and practical overview of multivariate outliers with a focus on common techniques used to identify and manage multivariate outliers. Specifically, this paper discusses the use of Mahalanobis distance and residual statistics as common multivariate outlier identification techniques. It also discusses the use of leverage and Cook's distance as two common techniques to determine the influence that multivariate outliers may have on statistical models. Finally, this paper discusses techniques that are commonly used to handle influential multivariate outlier cases.


Subject(s)
Models, Statistical , Research Personnel , Humans
8.
J Transcult Nurs ; 32(5): 508-517, 2021 09.
Article in English | MEDLINE | ID: mdl-33095098

ABSTRACT

INTRODUCTION: New immigrants underutilize health care because of multiple barriers. Although culturally competent health care improves access, it is typically assessed by providers, not newcomers whose perceptions matter most. METHODOLOGY: Surveys that included measures of cultural competence and health-related quality of life (QOL) were completed by 117 new immigrants in Windsor, Ontario, Canada. A series of stepwise linear regression analyses were conducted to identify independent predictors of QOL and its four domains: physical health, psychological, social relationships, and environment. RESULTS: Our adjusted results suggest that experiences of discrimination was negatively associated with overall QOL (ß = -.313; p < .001) and its psychological (ß = -.318; p < .001), social (ß = -.177; p = .048), and environmental (ß = -.408; p < .001) domains. DISCUSSION: Discrimination negatively influences new immigrant QOL. Provider cultural competency training should emphasize the influence of provider discrimination on immigrant health and explore learners' values and biases.


Subject(s)
Emigrants and Immigrants , Quality of Life , Cross-Sectional Studies , Cultural Competency , Health Personnel , Humans , Ontario
9.
J Pediatr Nurs ; 55: 232-238, 2020.
Article in English | MEDLINE | ID: mdl-32966963

ABSTRACT

PURPOSE: This cross-sectional study examined the frequency of different forms of bullying victimization (verbal, physical, and social), predictors of victimization, and whether bullying is reported to an adult. DESIGN AND METHODS: The study utilized a community sample of 150 Arab American adolescents, age 12 to 16 years. The Adolescent Peer Relations Instrument-Victimization Scale was used to determine the participant's experiences of victimization in the past year. The adolescents indicated where bullying occurred, why, and whether they reported the incidence to an adult. RESULTS: Approximately 30% of the study sample reported that victimization occurred occasionally (once a month or more frequent). Classrooms and hallways were the most common locations where bullying had occurred. Country-of-origin and obesity were the most frequent reasons for victimization. Predictors varied among the different forms of victimization; however, cyber-victimization [OR = 24.5; 95% CI 5-119.5)], perceived problematic attire [OR = 8.4; 95% CI 2.2-31.9)], female gender [OR = 5.2; 95% CI 1.2-22.7)], and being overweight [OR = 0.14; 95% CI 0.01-2.6)] all predicted overall victimization. CONCLUSIONS: Our findings provide a foundation for future research focusing on Arab American adolescents, an underrepresented population, more research is needed to understand the scope of bullying victimization among Arab American adolescents. PRACTICE IMPLICATIONS: This study will inform future intervention research and practice to consider victimization and related factors among Arab American adolescents. Culturally sensitive and multilevel interventions are imperative to decrease bullying victimization among Arab American adolescents and prevent negative effects on their health and families.


Subject(s)
Bullying , Crime Victims , Adolescent , Arabs , Child , Cross-Sectional Studies , Female , Humans , Michigan/epidemiology , Schools , United States
10.
Nurs Res ; 69(5): 339-346, 2020.
Article in English | MEDLINE | ID: mdl-32865945

ABSTRACT

BACKGROUND: Increasing evidence views hypertension as a stress-induced disorder. Stressors must be "gated" by the brain before any inflammatory or immune processes that contribute to hypertension are initiated. No studies were found that examined sensory gating in relation to hypertension. OBJECTIVES: The aim of the study was to determine if disturbances in self-reported sensory gating could differentiate normotensive from hypertensive young adults. METHODS: A nonmatched, case-control design was used. We administered an online survey to 163 young adult participants. Participants were predominantly female, in their mid-20s, well educated, and approximately evenly distributed by race and hypertension status. The Sensory Gating Inventory (SGI) measured gating disturbances. RESULTS: The mean SGI scores were significantly higher among persons diagnosed with hypertension, reflecting a moderate effect size of sensory gating. After adjusting for confounders, however, the normotensive and hypertensive groups were not significantly different on their SGI scores. DISCUSSION: With an observed moderate effect size of 0.35, but low power, more research is warranted regarding the role of gating disturbances in the development of stress-induced hypertension. Clinically, the SGI may be important for screening patients who would benefit from ambulatory blood pressure monitoring to identify persons with masked hypertension.


Subject(s)
Hypertension/psychology , Sensory Gating/physiology , Stress, Psychological/complications , Adolescent , Adult , Blood Pressure Monitoring, Ambulatory/instrumentation , Blood Pressure Monitoring, Ambulatory/methods , Case-Control Studies , Female , Humans , Hypertension/etiology , Internet , Male , Michigan , Self Report , Stress, Psychological/psychology , Surveys and Questionnaires
11.
J Emerg Nurs ; 46(4): 478-487, 2020 Jul.
Article in English | MEDLINE | ID: mdl-32507725

ABSTRACT

INTRODUCTION: Nonurgent visits to the emergency department compromise efficiency in treating patients with urgent conditions and inversely influence the satisfaction of patients and staff. There is inconclusive evidence of the factors associated with nonurgent ED visits. Therefore, the purpose of this study was to explore the independent factors associated with nonurgent ED visits in a midsize community-based Canadian hospital system. METHODS: This was a retrospective, secondary analysis of data from 2 community hospitals in southwestern Ontario, Canada. We included ED patients in the analysis if they were local residents from the city or the surrounding county. RESULTS: Nonurgent visits constituted approximately 27% of all ED visits and were more likely to be associated with patients with a primary care provider referral (odds ratio = 2.87; 95% confidence interval, 2.75-2.99) and with patients who had no primary care provider (odds ratio = 1.10; 95% confidence interval, 1.04-1.16). Other predictors included younger age, season, time of day, ED arrival mode, geographical proximity of residence to the emergency department, and case presentation. DISCUSSION: The findings of this study may assist health care providers and stakeholders in developing strategies to minimize nonurgent ED visits.


Subject(s)
Emergency Service, Hospital/statistics & numerical data , Health Services Misuse/statistics & numerical data , Efficiency, Organizational , Female , Hospitals, Community , Humans , Male , Middle Aged , Ontario , Retrospective Studies
12.
Article in English | MEDLINE | ID: mdl-32577152

ABSTRACT

This concept article introduces a transformative vision to reduce the population burden of chronic disease by focusing on data integration, analytics, implementation and community engagement. Known as PHOENIX (The Population Health OutcomEs aNd Information EXchange), the approach leverages a state level health information exchange and multiple other resources to facilitate the integration of clinical and social determinants of health data with a goal of achieving true population health monitoring and management. After reviewing historical context, we describe how multilevel and multimodal data can be used to facilitate core public health services, before discussing the controversies and challenges that lie ahead.

14.
West J Nurs Res ; 42(10): 829-837, 2020 10.
Article in English | MEDLINE | ID: mdl-32075545

ABSTRACT

Clinical judgment, one's ability to think like a nurse, is an essential skill for safe nursing practice. With the rise of simulation to replace clinical experiences, there is limited evidence regarding the effectiveness of simulation on the development of clinical judgment. This study explored differences in clinical judgment in maternal-newborn courses between undergraduate nursing students participating exclusively in simulation and those participating in hospital-based clinical experiences. Following completion of the clinical rotation, students participated in an evaluative maternal-newborn high-fidelity simulation experience that was recorded and evaluated using the Lasater's Clinical Judgment Rubric (2007). Lasater's Clinical Judgment Rubric scores between the simulation and clinical practice groups were compared using an independent sample t-test. There was no statistical difference in clinical judgment scores between the simulation and hospital-based clinical groups (t = -1.056, P = .295). Our findings suggest that simulation may be a comparable alternative to clinical experience in nursing education.


Subject(s)
Clinical Competence/standards , Maternal-Child Nursing/education , Students, Nursing/statistics & numerical data , Adolescent , Adult , Clinical Competence/statistics & numerical data , Curriculum/trends , Education, Nursing, Baccalaureate/methods , Education, Nursing, Baccalaureate/statistics & numerical data , Educational Measurement/methods , Female , High Fidelity Simulation Training , Humans , Male , Maternal-Child Nursing/methods , Maternal-Child Nursing/statistics & numerical data , Middle Aged
15.
Res Theory Nurs Pract ; 34(1): 35-48, 2020 Jan 01.
Article in English | MEDLINE | ID: mdl-31937635

ABSTRACT

BACKGROUND: Interventions in clinical trials should be clearly and completely described to inform their evaluation in replication studies and implementation in clinical practice. Guidelines were developed to standardize the reporting of interventions, but failed to provide guidance on reporting of the theory of interventions. Further, space constraints imposed by many research journals often limit the comprehensive description of both the theoretical and operational aspects of interventions. PURPOSE: To address these gaps, we propose that the theory of interventions be published in separate conceptual papers that would provide an in-depth description of the health problem targeted by an intervention, the components comprising an intervention, the causal mechanism responsible for an intervention's impact on the outcomes, and the conditions necessary for the proper implementation and the effectiveness of an intervention. IMPLICATIONS: Such papers would assist in the critical appraisal of the adequacy, implementation, and evaluation of interventions. A description of the theory of interventions clarifies to health professionals what the interventions are about, who is likely to benefit from the interventions, how the interventions work and under what context.


Subject(s)
Clinical Nursing Research/standards , Clinical Protocols/standards , Guidelines as Topic , Research Report/standards , Humans
16.
Nephrology (Carlton) ; 25(6): 491-496, 2020 Jun.
Article in English | MEDLINE | ID: mdl-31268610

ABSTRACT

AIM: Data about the optimal alteplase dose required to treat haemodialysis catheter occlusion (HDC) are scarce. The purpose of the clinical trial was to examine the effectiveness of alteplase 2 mg as compared with 1 mg in restoring HDC function. METHODS: A double-blind, randomized, controlled clinical trial was conducted in a single-centre in southwestern Ontario, Canada. Rate of clot resolution, catheter replacements, catheter stripping, and mean catheter survival time were assessed using Kaplan-Meier, Cox-proportional hazard and clustered logic regression analyses. RESULTS: On a sample of 48 haemodialysis patients who provided 252 catheter occlusion events, the rate of clot resolution at the catheter site in the 2 mg group was 85.7% as opposed to 84.9% in the 1 mg group. There were only six catheter removals and 10 catheter stripping events. Cox regression analysis revealed no difference between the two groups in the hazard of occlusion on the primary 48 observations after the initial alteplase management (P = 0.267; hazard ratio = 0.72; 95% confidence interval 0.40-1.3). Correlated logistic regression on all 252 observations indicated no difference in the rate of post alteplase clot resolution (P = 0.336; odds ratio = 2.4, 95% confidence interval 0.399-14.6) between the two groups. CONCLUSION: Alteplase 1 mg is as effective as 2 mg in restoring HDC malfunction and may result in cost reduction in haemodialysis units.


Subject(s)
Catheters, Indwelling/adverse effects , Fibrinolytic Agents/pharmacology , Renal Dialysis/adverse effects , Thrombosis/prevention & control , Tissue Plasminogen Activator/pharmacology , Aged , Aged, 80 and over , Double-Blind Method , Female , Humans , Logistic Models , Male , Middle Aged , Proportional Hazards Models
17.
J Emerg Nurs ; 46(2): 163-170, 2020 Mar.
Article in English | MEDLINE | ID: mdl-31685337

ABSTRACT

INTRODUCTION: Despite the plethora of research on the use of emergency department services for nonurgent primary health care, the vast majority of this research is quantitative in nature. To date, there is little research that reports on the problem from the patients' perspective and/or lived experience, which compromises health care providers' understanding of the essence of the problem as described by the patients. Thus, this study will provide a qualitative description of nonurgent ED visits from the patients' perspective. Specifically, this study answers the following research questions: 1) What are the reasons for patients and/or caregivers visiting the emergency department for nonurgent health conditions? and 2) What are the barriers experienced by patients and/or caregivers when seeking access to health care? METHODS: A qualitative descriptive design with face-to-face interviews of 33 consenting participants was conducted at 4 emergency departments. All interviewed participants were triaged as nonurgent patients by the ED personnel. RESULTS: Three themes surfaced from the data regarding reasons for using the emergency department: 1) Practitioner referral; 2) Efficacy of care; and 3) Time saver. When describing barriers that participants experienced when seeking care outside of the emergency department for their nonurgent conditions, 3 themes that emerged are lack of primary care provider, financial difficulties, and lack of comprehensive care outside the emergency department. DISCUSSION: The results of the study can help inform patient-centered care and future policy initiatives that will address the practices and barriers contributing to nonurgent ED visits.


Subject(s)
Emergency Service, Hospital/statistics & numerical data , Health Services Accessibility/statistics & numerical data , Health Services Misuse/statistics & numerical data , Patient Acceptance of Health Care/statistics & numerical data , Adult , Aged , Female , Humans , Interviews as Topic , Male , Middle Aged , Referral and Consultation/statistics & numerical data , Time , Young Adult
19.
Hemodial Int ; 23(4): 449-457, 2019 10.
Article in English | MEDLINE | ID: mdl-31361089

ABSTRACT

BACKGROUND: Vancomycin is the default antibiotic to treat methicillin-resistant Staphylococcus aureus (MRSA) in hemodialysis (HD) units. Current guidelines recommend a vancomycin trough range of 15 to 20 mg/L for serious infections. Data regarding the clinical success of these recommendations are scarce in HD patients. PURPOSE: The purpose of this studies is to evaluate the treatment outcomes of vancomycin in HD patients. METHODS: A retrospective chart review of HD outpatients who received parenteral vancomycin for suspected or documented MRSA infections in a community hospital in southwestern Ontario, Canada. Stepwise binary logistic regression analysis was conducted to identify the independent predictors of the treatment outcomes. RESULTS: Of 77 HD patients, 113 vancomycin treatment courses were identified. The unadjusted bivariate comparisons suggested that there was no difference between treatment success and failure groups in terms of: mean loading dose (1663.6 ± 451.9 mg vs. 1614.3 ± 471 mg, P = 0.621), mean pre-HD concentration after loading dose (12.78 ± 4.4 mg/L vs. 13.34 ± 4.5 mg/L, P = 0.601), and mean maintenance dose (1012.1 ± 108 mg vs. 1069.7 ± 227 mg, P = 0.093). The groups were, however, different on their mean pre-HD drug concentration after maintenance dose (15.99 ± 4.6 mg/L vs. 19.9 ± 5.8 mg/L, P = 0.002). The adjusted logistic regression results, however, suggested that the type of infection was the only independent predictor of vancomycin success (OR = 11.07; 95% confidence interval [CI] = 3.2-38.48). Specifically, patients treated for bacteremia were 11 times more likely to experience cure as compared with diabetic foot infection and/or osteomyelitis. Similarly, those with skin and soft tissue infections were 10.7 times more likely to experience cure than those with diabetic foot infection and/or osteomyelitis (OR = 10.7; 95% CI = 3.63-31.58). CONCLUSION: The suggested vancomycin pre-HD concentration in the guidelines did not predict the treatment outcomes. Patients with bacteremia and/or skin or soft tissue infections were more likely to achieve clinical cure than patients with diabetic foot/osteomyelitis infections.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Nephrology/methods , Pharmacists/standards , Renal Dialysis/methods , Vancomycin/therapeutic use , Anti-Bacterial Agents/pharmacology , Female , Humans , Male , Methicillin-Resistant Staphylococcus aureus , Middle Aged , Retrospective Studies , Treatment Outcome , Vancomycin/pharmacology
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