ABSTRACT
Disseminated adenoviral infection is a serious problem, especially in an immunocompromised host. The disease carries a mortality rate reaching as high as 80%. It is seen most frequently in bone marrow transplant recipients, where it causes pneumonia and disseminated disease. In solid organ transplant recipients it causes graft infection. We report the case of a renal transplant recipient with disseminated adenoviral infection and acute kidney failure requiring dialysis. Reduction of immunosuppression and 1 dose of cidofovir were associated with resolution of viremia and viruria and return of kidney function to near baseline.
Subject(s)
Adenovirus Infections, Human/etiology , Kidney Diseases/virology , Kidney Transplantation/adverse effects , Nephritis/virology , Adenovirus Infections, Human/drug therapy , Adenovirus Infections, Human/pathology , Adenovirus Infections, Human/virology , Aged , Antiviral Agents/therapeutic use , Cidofovir , Cytosine/analogs & derivatives , Cytosine/therapeutic use , Female , Humans , Kidney/pathology , Kidney Diseases/drug therapy , Kidney Diseases/etiology , Kidney Diseases/pathology , Nephritis/etiology , Organophosphonates/therapeutic use , Time FactorsABSTRACT
A monoclonal antibody to Schistosoma japonicum which conferred significant protection against cercarial challenge in mice was produced. The predicted translation product of the cDNA corresponding to the antigen recognized by this antibody was homologous to a newly identified family of actin-binding proteins. The expressed protein bound polymerized actin and was recognized by serum from patients infected with S. japonicum.
