ABSTRACT
Carotenoids come in second among the most frequent natural pigments and are utilized in medications, nutraceuticals, cosmetics, food pigments, and feed supplements. Based on recent complementary work, Virgibacillus was announced for the first time as a member of Wadi El-Natrun salt and soda lakes microbiota, identified as Virgibacillus halodenitrificans, and named V. halodenitrificans DASH; hence, this work aimed to investigate several in vitro medicinal bioactivities of V. halodenitrificans DASH carotenoids. The carotenoid methanolic extract showed antioxidant activity based on diphenylpicrylhydrazyl (DPPH) scavenging capacity with a half-maximal concentration (IC50) of 1.6 mg/mL as well as nitric oxide (NO) scavenging action expressed by an IC50 of 46.4 µg/mL. The extract showed considerable inhibitory activity for alpha-amylase (α-amylase) and alpha-glucosidase (α-glucosidase) enzymes (IC50 of 100 and 173.4 µg/mL, respectively). Moreover, the extract displayed selective anticancer activity against Caco-2 (IC50 = 138.96 µg/mL) and HepG-2 cell lines (IC50 = 31.25 µg/mL), representing colorectal adenocarcinoma and hepatoblastoma. Likewise, the extract showed 98.9 % clearance for human hepatitis C virus (HCV) using reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR), HCV-NS5B polymerase activity inhibition (IC50 = 27.4 µg/mL), and selective inhibitory activity against human coronavirus (HCoV 229E) using the plaque reduction assay (IC50 = 53.5 µg/mL). As far as we can tell, the anticancer, antiviral, and antidiabetic attributes of Virgibacillus carotenoids are, de novo, reported in this work which accordingly invokes further exploration of the other medicinal, biotechnological, and industrial applications of Virgibacillus and haloalkaliphilic bacteria carotenoids.
ABSTRACT
In this study, the main motivation of this work is desalination of water for irrigation arid area such as Sidri- Baba basins- south Sinai, Egypt. Also, the novelty of this work is modification of TFC surface membrane by mix of HA, DA and GO to get high performance of FO technique. Interfacial polymerization was employed to modify a thin-film composite (TFC) membrane for forward osmosis (FO) applications; moreover, graphene oxide (GO) nanosheets (GONs), a dopamine solution (DA), and naturally accessible humic acid (HA) were modified on a polyethersulfone (PES) substrate. The effects of the different quantities of GO, HA, and DA on the membrane surfaces, as well as their various cross-sectional morphologies and FO-desalination capabilities, were investigated. The integrated TFC membrane containing appropriate GO, HA, and DA blends outperformed the control membrane, obtaining high water flux, and high salt rejection. Furthermore,.
Subject(s)
Water , Cross-Sectional Studies , EgyptABSTRACT
The growth of the textile industry results in a massive accumulation of dyes on water. This enormous rise in pigments is the primary source of water pollution, affecting the aquatic lives and our ecosystem balance. This study aims to notify the fabrication of neodymium incorporated copper oxide (Nd2O3 doped CuO) nanoparticles by combustion method for effective degradation of dye, methylene blue (MB). X-ray diffraction (XRD), Field emission Scanning electron microscopy (FESEM), Zeta potential have been applied for characterization. Photocatalyst validity has been evaluated for methylene blue degradation (MB). Test conditions such as time of contact, H2O2, pH, and photo-Fenton have been modified to identify optimal degradation conditions. Noticeably, 7.5% Nd2O3 doped CuO nanoparticle demonstrated the highest photocatalytic efficiency, up to 90.8% in 80 min, with a 0.0227 min-1 degradation rate. However, the photocatalytic efficiency at pH 10 becomes 99% with a rate constant of 0.082 min-1. Cyclic experiments showed the Nd2O3 doped CuO nanoparticle's stability over repeated use. Scavenge hydroxyl radical species responsible for degradation using 7.5% Nd2O3 doped CuO nanoparticles have been investigated under visible irradiation.
ABSTRACT
Objective: To evaluate the prevalence, cleft types distribution and etiological risk factors among newly born babies with cleft lip and/or palate (CL±P) in four governorate of the Arab Republic of Egypt, beginning the 1st of January 2013 till the 31st of December 2013. Material and Methods: Total 237,783 newly born babies from Cairo (162174), Aswan (42880), Luxor (32729), and New Valley (877) governorate in the Arab Republic of Egypt were included in this study. Incidence of CL±P babies per 1000 births was calculated in each district for the four studied governorates. Percentage distribution of cleft types within each governorate. Chi-square test was used for determining significance of difference of incidence and percentages within and between the governorates. Results: The mean prevalence value of CL±P in the four Egyptian studied governorates was 0.40/1000. The highest percentage of cleft type was cleft lip and palate followed by cleft lip and isolated cleft palate. The highest etiological risk factor was maternal passive smoking in the four studied governorates followed by consanguineous marriage and medicine intake during pregnancy. Conclusion: These data provided a picture of the prevalence of CL±P in four different governorate of Egypt and also provided a useful reference for cleft types distribution and etiological risk factors of CL±P data in Egypt and internationally.
