ABSTRACT
The efficacy of phytogenic drug prolit septo in the complex treatment of patients with urolithiasis complicated by infectious-inflammatory process was evaluated. The effects of prolit septo were assessed by a comparative evaluation of the results of microbiological analysis of urine in 14 patients of main group and 12 patients of control group. Patients in both groups were matched by sex, age, and results of raiological, clinical, biochemical and microbiological methods of examination. For the treatment of 11 patients of the main group, prolit septo was applied in combination with standard anti-bacterial treatment, 3 patients received monotherapy with prolit septo within 3-6 weeks. The drug was administered at a dose of 1200 mg (2 capsules) 3 times a day. Twelve patients of the control group received only standard treatment. The duration of treatment in both groups was 1-2 weeks. It was found that combined therapy with prolit septo is more effective than standard antibacterial treatment. Against the background of combined therapy the disappearance of bacteriuria was noted in 54.5% of patients of main group compared with 8.3% of patients of control group.
Subject(s)
Bacteriuria/drug therapy , Enterococcus faecalis/drug effects , Gram-Positive Bacterial Infections/drug therapy , Klebsiella Infections/drug therapy , Klebsiella pneumoniae/drug effects , Phytotherapy , Urolithiasis/drug therapy , Adult , Anti-Bacterial Agents/therapeutic use , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Bacteriuria/complications , Bacteriuria/diagnosis , Creatinine/blood , Drug Therapy, Combination , Enterococcus faecalis/physiology , Female , Gram-Positive Bacterial Infections/complications , Gram-Positive Bacterial Infections/diagnosis , Humans , Klebsiella Infections/complications , Klebsiella Infections/diagnosis , Klebsiella pneumoniae/physiology , Male , Middle Aged , Phyllanthus , Plant Extracts/therapeutic use , Urolithiasis/complications , Urolithiasis/diagnosis , Young AdultABSTRACT
A comparison was made of chemoradiation lesions of lower urinary tract mucosa in urinary bladder (UB) cancer at stage T1-3N0-1MO and approaches to their treatment. An optimal algorithm of examination and treatment of the above patients with consideration of the disease stage and somatic status is proposed.
Subject(s)
Drug-Related Side Effects and Adverse Reactions , Radiotherapy/adverse effects , Urinary Bladder Neoplasms/drug therapy , Urinary Bladder Neoplasms/radiotherapy , Algorithms , Cystitis/chemically induced , Cystitis/pathology , Dose Fractionation, Radiation , Female , Humans , Male , Pain/etiology , Retrospective StudiesABSTRACT
The report reviews the experience gained with radio- and chemotherapy-related injuries suffered by bladder cancer patients. It corroborates the opinion of most European specialists that indications for radical cystectomy be extended with due considerations of up-to-date potential in anesthesiology, extensive care and pharmacology. Possible untoward side effects of radiation and intravesical chemotherapy as well as means of solution of the problem are discussed. It is urgent considering the constantly growing number of such patients, their age and associated somatic problems.
Subject(s)
Antineoplastic Agents/administration & dosage , Antineoplastic Agents/adverse effects , Urinary Bladder Neoplasms/pathology , Urinary Bladder/drug effects , Urinary Bladder/radiation effects , Administration, Intravesical , Adult , Aged , Chemotherapy, Adjuvant/adverse effects , Female , Humans , Male , Middle Aged , Mucous Membrane/drug effects , Mucous Membrane/radiation effects , Neoplasm Staging , Radiotherapy, Adjuvant/adverse effects , Urinary Bladder/pathology , Urinary Bladder Neoplasms/drug therapy , Urinary Bladder Neoplasms/radiotherapyABSTRACT
An evaluation of damage caused by radiation and chemical drugs to urinary bladder mucosa in stage T1-T2N0V0 cancer is presented and therapeutic modalities are discussed. The authors summarize their experience and offer recommendations for optimal treatment of the disease. Also, suggestions are made how to work out indications and contraindications in dealing with a specific urinary bladder cancer vis-avis stage and possible complications.
