ABSTRACT
INTRODUCTION: Nasal NK/T-cell lymphoma is a rare but well-known clinical entity. Thanks to improvements in anatomopathology and the development of routine immunohistochemistry, the diagnosis of nasal NK/T-cell lymphoma (NK for "natural killer") was recognized by the WHO in 2001. The main differential diagnosis is with Wegener's granulomatosis. Treatment is based on radiotherapy and chemotherapy. Prognosis is poor, with variable evolution and sometimes rapid progression. CASE REPORT: The authors report the case of a 54-year-old man without known pathological history, who presented with bilateral nasal obstruction with purulent rhinorrhea. Diagnosis was made on the basis of immunohistochemical study of biopsy samples. The tumor was graded IE on the Ann Arbor classification. Treatment, comprising CHOP chemotherapy followed by radiotherapy, achieved total remission at 8 months' follow-up. DISCUSSION/CONCLUSION: Sinonasal NK/T-cell lymphoma is rare. Diagnosis is based on immunophenotypic and molecular characteristics. It is an aggressive lymphoma, requiring multidisciplinary management. Prognosis is poor.
Subject(s)
Lymphoma, Extranodal NK-T-Cell/pathology , Lymphoma, Extranodal NK-T-Cell/therapy , Maxillary Sinus Neoplasms/pathology , Maxillary Sinus Neoplasms/therapy , Nose Neoplasms/pathology , Nose Neoplasms/therapy , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Biopsy , Chemotherapy, Adjuvant/methods , Diagnosis, Differential , Follow-Up Studies , Humans , Lymphoma, Extranodal NK-T-Cell/diagnosis , Male , Maxillary Sinus Neoplasms/diagnosis , Middle Aged , Neoplasm Grading , Neoplasm Invasiveness , Nose Neoplasms/diagnosis , Prognosis , Radiotherapy, Adjuvant/methods , Rare Diseases , Treatment OutcomeABSTRACT
Tuberculous of the oral cavity is rare, the attack tonsil remains exceptional. We report case a 25-year-old young male, who consults for an ulceration of the left unilateral tonsil, with a homolateral adenopathy jugulo-carotidien. The examination anatomopathologic of the tonsil biopsy revealed a tuberculous of the tonsil. The patient profited from an antituberculous treatment, the evolution was good.
Subject(s)
Tonsillitis/microbiology , Tuberculosis/diagnosis , Adult , Antitubercular Agents/therapeutic use , Diagnosis, Differential , Humans , Male , Tonsillar Neoplasms/diagnosis , Tonsillitis/diagnosis , Tonsillitis/drug therapy , Tuberculosis/drug therapyABSTRACT
INTRODUCTION: Alveolar rhabdomyosarcoma of salivary glands is a rare malignant neoplasm, presenting a striated muscular differentiation. It is typically observed in children, adolescents, and young adults but can sometimes be diagnosed in older people. OBSERVATION: We report the case of a 57 year-old man presenting with a primary alveolar rhabdomyosarcoma of the parotid gland. The patient was treated by surgery and radiotherapy. DISCUSSION: According to literature data, alveolar rhabdomyosarcoma of the parotid gland is exceptionally described after 40 years of age. In that case it has the worst prognosis and its lethality is due mainly to its very early metastasis.
Subject(s)
Parotid Neoplasms/diagnosis , Rhabdomyosarcoma, Alveolar/diagnosis , Cell Nucleus/ultrastructure , Cytoplasm/ultrastructure , Fatal Outcome , Humans , Male , Middle Aged , MyoD Protein/analysis , Neoadjuvant Therapy , Vimentin/analysisABSTRACT
The laryngeal tuberculous is the most frequent granulomatous disease of the larynx. It is generally associated with a pulmonary cave, and represents a prognosis element extremely serious and can be complicated extreme dysphagia and pains. Among all the extrapulmonary localisations. The isolated laryngée localisation is rare. It is secondary the dissemination coming hematogen, air or lymphatic way. All the structures of the larynx can be reached. The beginning is progressive and insidious and appears by the dysphony, cough, the odynophagy and dyspnea. We report the case of laryngeal tuberculosis in a 21 year old young man. The authors point out the characteristics of this localization and insist on the biopsy in front of any chronic laryngitis no aetiology. The treatment is medical.
Subject(s)
Tuberculosis, Laryngeal/complications , Tuberculosis, Laryngeal/diagnosis , Adult , Humans , Male , Severity of Illness Index , Tuberculosis, Laryngeal/pathology , Voice Disorders/diagnosis , Voice Disorders/etiologyABSTRACT
We report a case of a 36 year old woman who presented a chronic rhinitis and a hypertrophy of the inferior turbinates. Primary nasal tuberculosis was discovered by chance after the inferior turbinectomy. Primary nasal tuberculosis is very rare and is more frequent in women. Symptomatology is often unilateral with nasal obstruction, anterior rhinorrhea or epistaxis. The clinical examination may discover ulceration or a polyp located generally in the nasal septum or the inferior turbinate. Diagnosis relies on the anatomopathologic and bacteriological examinations. The treatment is mainly medical based on antituberculosis drugs. In the light of this case report, a review of the literature was made.
