ABSTRACT
Atypical chronic myeloid leukaemia (aCML) belongs to the myeloproliferative/myelodysplastic category of haematological disease. Main characteristics are marked dysgranulopoiesis, bone marrow dysfunction and the failure to demonstrate the presence of the Philadelphia chromosome or BCR/ABL fusion gene normally associated with CML t(9;22)(q34;q11). It carries a poor prognosis with limited therapeutic options available. Most cases of aCML have one or more karyotypic abnormalities. We highlight a clinical presentation of aCML associated with an acquired reciprocal whole-arm translocation (WAT), t(X;12)(p10;p10), which to our knowledge has not yet been described. We also discuss how such a translocation might lead to tumorigenesis.
Subject(s)
Chromosomes, Human, Pair 12/ultrastructure , Chromosomes, Human, X/ultrastructure , Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative/genetics , Translocation, Genetic , Aged , Cell Transformation, Neoplastic , Chromosomes, Human, Pair 12/genetics , Chromosomes, Human, X/genetics , Clone Cells/ultrastructure , Combined Modality Therapy , Cranial Irradiation , Female , Humans , Hypophysectomy , Incidental Findings , Karyotyping , Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative/pathology , Neoplasms, Second Primary/genetics , Neoplastic Stem Cells/ultrastructure , Octreotide/therapeutic use , Pituitary Neoplasms/radiotherapy , Pituitary Neoplasms/surgery , Radiotherapy, AdjuvantABSTRACT
Low doses (0.05 mg/kg) of intravenously administered droperidol were given intraoperatively to randomly assigned pediatric strabismus patients in a controlled double-masked paradigm. No difference between control and treatment groups in the severity of vomiting was noted in the postanesthesia recovery room, but such a difference was probably present in the hospital rooms during the interval between room arrival and the meeting of hospital discharge criteria. Administration of the drug did not appear to produce somnolence sufficient to delay postoperative recovery.
