Altered Mental Status on Top of Anaplasmosis-Induced Severe Rhabdomyolysis: A Rare Clinical Presentation.

Human granulocytic anaplasmosis (HGA) is a disease caused by tick-borne infection of Anaplasma phagocytophilum. The typical symptoms are fever, malaise, and body aches accompanied by abnormal blood tests such as leukopenia, thrombocytopenia, and transaminitis. Some rare complications may occur, especially in patients living in heavily wooded areas, with a mean age of 70 years. We present a case of a 67-year-old male who was admitted for lower abdominal pain, fever, and diarrhea with derangement of his blood tests. Despite treatment, his condition deteriorated and complicated rhabdomyolysis and acute kidney dysfunction. Empiric treatment including doxycycline was initiated while waiting for the infection blood work results. PCR came back positive for HGA. Empiric therapy was narrowed down to doxycycline for 14 days, and the patient's condition began to improve gradually and steadily. Aggressive hydration markedly improved rhabdomyolysis and, in turn, kidney function. Our case underscores the importance of considering HGA in ambiguous clinical scenarios and highlights the value of early diagnosis, empiric treatment, and intravenous hydration, especially in the presence of rhabdomyolysis.

Clinical Decision Support Systems to Predict Drug-Drug Interaction Using Multilabel Long Short-Term Memory with an Autoencoder.

Big Data analytics is a technique for researching huge and varied datasets and it is designed to uncover hidden patterns, trends, and correlations, and therefore, it can be applied for making superior decisions in healthcare. Drug-drug interactions (DDIs) are a main concern in drug discovery. The main role of precise forecasting of DDIs is to increase safety potential, particularly, in drug research when multiple drugs are co-prescribed. Prevailing conventional method machine learning (ML) approaches mainly depend on handcraft features and lack generalization. Today, deep learning (DL) techniques that automatically study drug features from drug-related networks or molecular graphs have enhanced the capability of computing approaches for forecasting unknown DDIs. Therefore, in this study, we develop a sparrow search optimization with deep learning-based DDI prediction (SSODL-DDIP) technique for healthcare decision making in big data environments. The presented SSODL-DDIP technique identifies the relationship and properties of the drugs from various sources to make predictions. In addition, a multilabel long short-term memory with an autoencoder (MLSTM-AE) model is employed for the DDI prediction process. Moreover, a lexicon-based approach is involved in determining the severity of interactions among the DDIs. To improve the prediction outcomes of the MLSTM-AE model, the SSO algorithm is adopted in this work. To assure better performance of the SSODL-DDIP technique, a wide range of simulations are performed. The experimental results show the promising performance of the SSODL-DDIP technique over recent state-of-the-art algorithms.

Influence of Channel Selection and Subject's Age on the Performance of the Single Channel EEG-Based Automatic Sleep Staging Algorithms.

The electroencephalogram (EEG) signal is a key parameter used to identify the different sleep stages present in an overnight sleep recording. Sleep staging is crucial in the diagnosis of several sleep disorders; however, the manual annotation of the EEG signal is a costly and time-consuming process. Automatic sleep staging algorithms offer a practical and cost-effective alternative to manual sleep staging. However, due to the limited availability of EEG sleep datasets, the reliability of existing sleep staging algorithms is questionable. Furthermore, most reported experimental results have been obtained using adult EEG signals; the effectiveness of these algorithms using pediatric EEGs is unknown. In this paper, we conduct an intensive study of two state-of-the-art single-channel EEG-based sleep staging algorithms, namely DeepSleepNet and AttnSleep, using a recently released large-scale sleep dataset collected from 3984 patients, most of whom are children. The paper studies how the performance of these sleep staging algorithms varies when applied on different EEG channels and across different age groups. Furthermore, all results were analyzed within individual sleep stages to understand how each stage is affected by the choice of EEG channel and the participants' age. The study concluded that the selection of the channel is crucial for the accuracy of the single-channel EEG-based automatic sleep staging methods. For instance, channels O1-M2 and O2-M1 performed consistently worse than other channels for both algorithms and through all age groups. The study also revealed the challenges in the automatic sleep staging of newborns and infants (1-52 weeks).

Manta Ray Foraging Optimization Transfer Learning-Based Gastric Cancer Diagnosis and Classification on Endoscopic Images.

Gastric cancer (GC) diagnoses using endoscopic images have gained significant attention in the healthcare sector. The recent advancements of computer vision (CV) and deep learning (DL) technologies pave the way for the design of automated GC diagnosis models. Therefore, this study develops a new Manta Ray Foraging Optimization Transfer Learning technique that is based on Gastric Cancer Diagnosis and Classification (MRFOTL-GCDC) using endoscopic images. For enhancing the quality of the endoscopic images, the presented MRFOTL-GCDC technique executes the Wiener filter (WF) to perform a noise removal process. In the presented MRFOTL-GCDC technique, MRFO with SqueezeNet model is used to derive the feature vectors. Since the trial-and-error hyperparameter tuning is a tedious process, the MRFO algorithm-based hyperparameter tuning results in enhanced classification results. Finally, the Elman Neural Network (ENN) model is utilized for the GC classification. To depict the enhanced performance of the presented MRFOTL-GCDC technique, a widespread simulation analysis is executed. The comparison study reported the improvement of the MRFOTL-GCDC technique for endoscopic image classification purposes with an improved accuracy of 99.25%.

Optimal Deep Transfer Learning-Based Human-Centric Biomedical Diagnosis for Acute Lymphoblastic Leukemia Detection.

Human-centric biomedical diagnosis (HCBD) becomes a hot research topic in the healthcare sector, which assists physicians in the disease diagnosis and decision-making process. Leukemia is a pathology that affects younger people and adults, instigating early death and a number of other symptoms. Computer-aided detection models are found to be useful for reducing the probability of recommending unsuitable treatments and helping physicians in the disease detection process. Besides, the rapid development of deep learning (DL) models assists in the detection and classification of medical-imaging-related problems. Since the training of DL models necessitates massive datasets, transfer learning models can be employed for image feature extraction. In this view, this study develops an optimal deep transfer learning-based human-centric biomedical diagnosis model for acute lymphoblastic detection (ODLHBD-ALLD). The presented ODLHBD-ALLD model mainly intends to detect and classify acute lymphoblastic leukemia using blood smear images. To accomplish this, the ODLHBD-ALLD model involves the Gabor filtering (GF) technique as a noise removal step. In addition, it makes use of a modified fuzzy c-means (MFCM) based segmentation approach for segmenting the images. Besides, the competitive swarm optimization (CSO) algorithm with the EfficientNetB0 model is utilized as a feature extractor. Lastly, the attention-based long-short term memory (ABiLSTM) model is employed for the proper identification of class labels. For investigating the enhanced performance of the ODLHBD-ALLD approach, a wide range of simulations were executed on open access dataset. The comparative analysis reported the betterment of the ODLHBD-ALLD model over the other existing approaches.

An Automated Glowworm Swarm Optimization with an Inception-Based Deep Convolutional Neural Network for COVID-19 Diagnosis and Classification.

Recently, the COVID-19 epidemic has had a major impact on day-to-day life of people all over the globe, and it demands various kinds of screening tests to detect the coronavirus. Conversely, the development of deep learning (DL) models combined with radiological images is useful for accurate detection and classification. DL models are full of hyperparameters, and identifying the optimal parameter configuration in such a high dimensional space is not a trivial challenge. Since the procedure of setting the hyperparameters requires expertise and extensive trial and error, metaheuristic algorithms can be employed. With this motivation, this paper presents an automated glowworm swarm optimization (GSO) with an inception-based deep convolutional neural network (IDCNN) for COVID-19 diagnosis and classification, called the GSO-IDCNN model. The presented model involves a Gaussian smoothening filter (GSF) to eradicate the noise that exists from the radiological images. Additionally, the IDCNN-based feature extractor is utilized, which makes use of the Inception v4 model. To further enhance the performance of the IDCNN technique, the hyperparameters are optimally tuned using the GSO algorithm. Lastly, an adaptive neuro-fuzzy classifier (ANFC) is used for classifying the existence of COVID-19. The design of the GSO algorithm with the ANFC model for COVID-19 diagnosis shows the novelty of the work. For experimental validation, a series of simulations were performed on benchmark radiological imaging databases to highlight the superior outcome of the GSO-IDCNN technique. The experimental values pointed out that the GSO-IDCNN methodology has demonstrated a proficient outcome by offering a maximal sensy of 0.9422, specy of 0.9466, precn of 0.9494, accy of 0.9429, and F1score of 0.9394.

DNA binding, photo-induced DNA cleavage and cytotoxicity studies of lomefloxacin and its transition metal complexes.

This work was focused on a study of the DNA binding and cleavage properties of lomefloxacin (LMF) and its ternary transition metal complexes with glycine. The nature of the binding interactions between compounds and calf thymus DNA (CT-DNA) was studied by electronic absorption spectra, fluorescence spectra and thermal denaturation experiments. The obtained results revealed that LMF and its complexes could interact with CT-DNA via partial/moderate intercalative mode. Furthermore, the DNA cleavage activities of the compounds were investigated by gel electrophoresis. Mechanistic studies of DNA cleavage suggest that singlet oxygen ((1)O2) is likely to be the cleaving agent via an oxidative pathway, except for Cu(II) complex which proceeds via both oxidative and hydrolytic pathways. Antimicrobial and antitumor activities of the compounds were also studied against some kinds of bacteria, fungi and human cell lines.