1.
J Med Chem
; 41(25): 5108-12, 1998 Dec 03.
Article
in English
| MEDLINE
| ID: mdl-9836626
ABSTRACT
The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position and their antiviral activity are reported. From the synthesized compounds, 4, 15, and 21 were highly active against human cytomegalovirus with a therapeutic index superior to 150. These compounds also showed pronounced activity against varicella-zoster virus. Their structure-activity relationship is discussed.
Subject(s)
Antiviral Agents/chemical synthesis , Imidazoles/chemical synthesis , Pyridines/chemical synthesis , Animals , Antiviral Agents/chemistry , Antiviral Agents/pharmacology , Cell Line , Chlorocebus aethiops , Cytomegalovirus/drug effects , Drug Evaluation, Preclinical , HeLa Cells , Herpesvirus 3, Human/drug effects , Humans , Imidazoles/chemistry , Imidazoles/pharmacology , Inhibitory Concentration 50 , Pyridines/chemistry , Pyridines/pharmacology , Structure-Activity Relationship , Vero Cells
2.
J Med Chem
; 39(14): 2856-9, 1996 Jul 05.
Article
in English
| MEDLINE
| ID: mdl-8709116
ABSTRACT
The synthesis and the antiviral activities of C-3 acyclic nucleoside analogues of imidazo[1,2-a]pyridine and pyrimidine are reported. From these compounds, 20, 21, 22, 23, 28, and 34 showed a specific activity against cytomegalovirus and/or varicella-zoster virus.
