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Transpl Int ; 26(8): 833-41, 2013 Aug.
Article in English | MEDLINE | ID: mdl-23782175

ABSTRACT

This 5 year observational multicentre study conducted in the Nord Italian Transplant programme area evaluated outcomes in patients receiving kidneys from donors over 60 years allocated according to a combined clinical and histological algorithm. Low-risk donors 60-69 years without risk factors were allocated to single kidney transplant (LR-SKT) based on clinical criteria. Biopsy was performed in donors over 70 years or 60-69 years with risk factors, allocated to Single (HR-SKT) or Dual kidney transplant (HR-DKT) according to the severity of histological damage. Forty HR-DKTs, 41 HR-SKTs and 234 LR-SKTs were evaluated. Baseline differences generally reflected stratification and allocation criteria. Patient and graft (death censored) survival were 90% and 92% for HR-DKT, 85% and 89% for HR-SKT, 88% and 87% for LR-SKT. The algorithm appeared user-friendly in daily practice and was safe and efficient, as demonstrated by satisfactory outcomes in all groups at 5 years. Clinical criteria performed well in low-risk donors. The excellent outcomes observed in DKTs call for fine-tuning of cut-off scores for allocation to DKT or SKT in high-risk patients.


Subject(s)
Graft Survival , Kidney Failure, Chronic/surgery , Kidney Transplantation , Kidney/pathology , Aged , Aged, 80 and over , Algorithms , Biopsy , Cadaver , Delayed Graft Function , Female , Humans , Italy , Kidney Transplantation/mortality , Male , Middle Aged , Retrospective Studies , Risk Factors , Tissue Donors , Treatment Outcome
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