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Cutis ; 76(3): 189-92, 2005 Sep.
Article in English | MEDLINE | ID: mdl-16268263

ABSTRACT

A skin eruption consistent with subacute cutaneous lupus erythematosus (SCLE) occurred in a patient taking leflunomide for rheumatoid arthritis. The eruption resolved after discontinuation of the medication. Suppression of tumor necrosis factor (TNF)-effector mechanisms by leflunomide may have played a role in the pathogenesis of this disorder.


Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Isoxazoles/adverse effects , Lupus Erythematosus, Cutaneous/chemically induced , Arthritis, Rheumatoid/drug therapy , Female , Humans , Leflunomide , Middle Aged
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