Subject(s)
Breast Diseases/pathology , Adolescent , Biopsy , Breast Diseases/diagnosis , Female , Humans , Hyperplasia/diagnosis , Hyperplasia/pathologyABSTRACT
Atypical duct hyperplasia of the breast is an unusual finding in the adolescent or young adult female. We report nine young women, ages 18-26 years (mean 21) with atypical duct hyperplasia. Clinical presentation was either breast hypertrophy treated by reduction mammoplasty (five patients) or a thickening or mass that was examined via biopsy (four patients). No focal abnormalities were present on gross examination other than two fibroadenomas in one patient. Microscopically, isolated hyperplastic ducts were scattered in a background of prominent stromal collagenization. Each case showed a continuum of ductal changes, from partial to complete involvement by micropapillary and laciform epithelial hyperplasia, which was sometimes markedly atypical. In four, lobules were poorly developed or not present in the available sections. During a follow-up of 5-68 months (mean 39), none developed breast carcinoma. Much longer follow-up is needed to determine if young women with atypical duct hyperplasia are at increased risk for subsequent development of breast carcinoma. Presently, no surgical or medical intervention is recommended, but such patients should perform breast self-examination and be monitored regularly by a physician.
Subject(s)
Breast Diseases/pathology , Breast/pathology , Adenofibroma/pathology , Adolescent , Adult , Age Factors , Biopsy , Breast/surgery , Breast Diseases/surgery , Breast Neoplasms/pathology , Epithelium/pathology , Female , Follow-Up Studies , Humans , Hyperplasia , Immunohistochemistry , Time FactorsABSTRACT
A total of 203 primary invasive breast cancers were sampled by ex vivo fine-needle aspiration (FNA), directly yielding adequate single cell suspensions for flow cytometric DNA analysis in 194 (96%). Labor-intensive and time-consuming steps of mechanical and enzymatic cellular disaggregation required by the use of fresh, frozen, or paraffin-embedded tissue were avoided, thereby minimizing preparation time. Conservation of tumor tissue allowed for the sampling of very small breast cancers. DNA ploidy and S-phase fraction data were comparable to flow cytometric data reported in other breast cancer studies using various sampling methods. Ex vivo FNA is the easiest and fastest method for sampling breast cancers for flow cytometric DNA analysis.
Subject(s)
Breast Neoplasms/pathology , DNA, Neoplasm/genetics , Ploidies , Biopsy, Needle , Breast Neoplasms/chemistry , Breast Neoplasms/genetics , Cell Division , Cell Fractionation/methods , DNA, Neoplasm/analysis , Female , Flow Cytometry/methods , Humans , S Phase , Specimen HandlingABSTRACT
A right adrenal gland mass was found during sonographic examination of the right upper quadrant during a workup for hyperemesis gravidarum. Magnetic resonance imaging was used to clarify the origin of the mass. The tumor was nonfunctional. Because of the possibility of a malignancy, the patient underwent a successful second-trimester exploratory laparatomy with right adrenalectomy. Pathology demonstrated a benign ganglioneuroma.
