ABSTRACT
A follow-up study was conducted on 60 patients who had standard en bloc anterior temporal lobe resection, including mesiotemporal structures, as treatment for temporal lobe lesions associated with chronic, medically intractable seizures. Lesions were identified as glial tumors, hamartomas, or vascular malformations. Long-term outcome was assessed in terms of seizure frequency and certain psychosocial sequelae. Seizure onset occurred at an average age of 15 years (median = 13.5 years), and patients experienced seizures for an average of 13 years prior to surgery. The mean time of follow-up was 8.4 years postsurgery (median = 6 years). The Kaplan-Meier curve at median follow-up showed a seizure-free rate of 80%. Late seizure recurrence was documented for three patients; two had been seizure-free for 10 years and one for 15 years after surgery, before re-onset of seizures in the absence of tumor recurrence. A prolonged history of seizures prior to surgery was associated with a poorer seizure outcome (p = 0.06), suggesting that secondary epileptogenesis at sites distant to the lesion may develop with years of uncontrolled seizures. There was a low tumor recurrence rate of 3.3% (two cases). The psychosocial outcome was generally good, with 67% working or engaged in educational studies, and improvement noted in 59% of cases for one or more of the psychosocial factors investigated. This study confirms that anterior temporal lobe resection for temporal lesions associated with chronic seizures is a successful treatment with a high seizure-free rate following surgery and good psychosocial outcome.
Subject(s)
Brain Diseases/complications , Brain Diseases/surgery , Seizures/etiology , Temporal Lobe/surgery , Adaptation, Psychological , Adolescent , Brain Neoplasms/complications , Brain Neoplasms/surgery , Chronic Disease , Female , Follow-Up Studies , Glioma/complications , Glioma/surgery , Hamartoma/complications , Hamartoma/surgery , Humans , Intracranial Arteriovenous Malformations/complications , Intracranial Arteriovenous Malformations/surgery , Male , Seizures/physiopathology , Social Adjustment , Time Factors , Treatment OutcomeABSTRACT
A follow-up study was conducted on 60 patients who had standard en bloc anterior temporal lobe resection, including mesio-temporal structures, as treatment for temporal lobe lesions associated with chronic, medically intractable seizures. Lesions were identified as glial tumors, hamartomas, or vascular malformations. Long-term outcome was assessed in terms of seizure frequency and certain psychosocial sequelae. Seizure onset occurred at an average age of 15 years (median = 13.5 years), and patients experienced seizures for an average of 13 years prior to surgery. The mean time of follow-up was 8.4 years post-surgery (median = 6 years). The Kaplan-Meier curve at median follow-up showed a seizure-free rate of 80%. Late seizure recurrence was documented for three patients; two had been seizure free for 10 years and one for 15 years after surgery before re-onset of seizures in the absence of tumor recurrence. A prolonged history of seizures prior to surgery was associated with a poorer seizure outcome (p = 0.06), suggesting that secondary epileptogenesis at sites distant to the lesion may develop with years of uncontrolled seizures. There was a low tumor recurrence rate of 3.3% (two cases). The psychosocial outcome was generally good, with 67% working or engaged in educational studies, and improvement noted in 59% of cases for one or more of the psychosocial factors investigated. This study confirms that anterior temporal lobe resection for temporal lesions associated with chronic seizures is a successful treatment with a high seizure-free rate following surgery and good psychosocial outcome.
Subject(s)
Brain Diseases/complications , Brain Diseases/surgery , Brain Neoplasms/complications , Seizures/etiology , Temporal Lobe/surgery , Adaptation, Psychological , Adolescent , Brain Neoplasms/surgery , Chronic Disease , Female , Follow-Up Studies , Glioma/complications , Glioma/surgery , Hamartoma/complications , Hamartoma/surgery , Humans , Intracranial Arteriovenous Malformations/complications , Intracranial Arteriovenous Malformations/surgery , Male , Seizures/physiopathology , Social Adjustment , Time Factors , Treatment OutcomeABSTRACT
Epilepsy was the first clinical entity to which magnetic source imaging was applied; however, the technology available severely limited early studies. The introduction of large-array magnetic source imaging systems has enabled striking advances in the application of magnetic source imaging in epilepsy surgery programs. The superimposition of functional localization of epileptic sources on anatomic images from MR imaging or computed tomography allows precise definition of the area and extent of epileptogenic tissue for possible resection. Concordance of magnetic source imaging indications with other noninvasive studies may reduce that need for invasive studies in certain patient populations.
