ABSTRACT
The author discusses some mechanisms, conditioning the double role of carbon dioxide in the genesis of epileptical activity, first as a provocative factor, when carbon dioxide is a background against which the epileptical seizure appears and then as arresting the sequalae during the administration of CO2 during a seizure. It was demonstrated that the different action of CO2 was due to different phases in the changed functional state of the brain. The study was accomplished on 80 rabbits of the chenchille breed. The evalution of phases in changes of the functional state of the brain was performed with the aid of the encephalographic method.
Subject(s)
Brain/physiopathology , Carbon Dioxide , Seizures/physiopathology , Animals , Carbon Dioxide/therapeutic use , Carbon Dioxide/toxicity , Chinchilla , Dose-Response Relationship, Drug , Electroencephalography , Pentylenetetrazole , Rabbits , Seizures/chemically induced , Seizures/therapyABSTRACT
A study was made of changes in the spectrum of brain electrical activity of rabbits, due to changes in the functional state of the brain, induced by means of a smooth rise in CO2 concentration in the air inhaled by the animals. Transformation of the general spectral characteristics has been revealed which consists in simultaneous re-distribution of frequency ranges and changes in the proportion of alpha-like, theta- and sigma-rhythms.
Subject(s)
Brain/physiology , Carbon Dioxide , Electroencephalography , Respiration , Animals , RabbitsABSTRACT
The influence of prolonged electrical stimulation of rabbit hypothalamus on blood lipids and the development of atherosclerosis were studied. The negative emotional state observed during the electrical stimulation was accompanied by blood hyperlipemia and atherosclerosis development in 1/3 noncastrated and 2/3 castrated animals.
