A utilização da acupuntura no controlo da dor crónica em usuários com síndrome vertebral com irradiação / The use of acupuncture to control chronic pain in users with irradiated vertebral syndrome

Objetivos: a acupuntura é, cada vez mais, uma técnica utilizada, em usuários portadores de várias patologias, e, em especial, aquelas que são acompanhadas de dor crónica. Esta pesquisa teve como objetivo geral analisar o efeito da terapêutica não farmacológica de acupuntura e eletroacupuntura para o controle da dor crónica, em usuários com diagnóstico médico de síndrome vertebral com irradiação. Métodos: foi realizada uma pesquisa com dois momentos de avaliação ­ antes e após sessões de terapêutica não farmacológica de acupuntura e eletroacupuntura. Utilizou-se um questionário com variáveis de caracterização sociodemográfica e clínica, o Brief Pain Inventory (BPI)e Short Form 6 Dimensions (SF-6D). Resultados: participaram no estudo 43 usuários, tendo sido encontradas diferenças estaticamente significativas, do momento 1 para o momento 2 de avaliação, quer no domínio da severidade da dor (p<0,01), quer no domínio interferência da dor no funcionamento diário (p<0,01), assim como nas diferentes dimensões do SF-6D foram encontradas diferenças estatisticamente significativas. Conclusões: salienta-se que a terapêutica não farmacológica de acupuntura e eletroacupuntura em usuários com diagnóstico de síndrome vertebral com irradiação e dor crónica contribuiu para a diminuição da severidade da dor, da interferência da dor no funcionamento diário e melhoria da qualidade de vida relacionada com a saúde.

Aims: acupuncture is increasingly a technique used in users with various pathologies, and especially those who are accompanied by chronic pain. This research aimed to analyze the effect of non-pharmacological acupuncture and electroacupuncture therapy for the control of chronic pain in users with medical diagnosis of irradiation vertebral syndrome. Methods: a research was conducted with two evaluation moments: before and after non-pharmacological acupuncture and electroacupuncture therapy sessions. A questionnaire with variables of sociodemographic and clinical characterization, the Brief Pain Inventory and Short Form 6 Dimensions (SF-6D) was used. Results: forty-three users participated in the study, and statistically significant differences were found from moment 1 to moment 2 of evaluation, either in the pain severity domain (p<0.01) or in the pain interference domain in daily functioning (p <0.01), as well as in the different dimensions of SF-6D, statistically significant differences were found. Conclusions: non-pharmacological acupuncture and electroacupuncture therapy in users diagnosed with irradiation and chronic pain have contributed to decrease pain severity, pain interference in daily functioning and improvement of health-related quality of life.

New lake in a changing world: the construction and filling of a small hydropower reservoir in the tropics (Rio de Janeiro, Brazil).

Climate change has affected rainfall patterns in tropical regions, where simultaneous demands for water and energy, habitat loss, declining biodiversity, and spread of invasive species have reflected a rapidly changing world underway. In Brazil, hydropower generation accounts for 64% of the electricity matrix, which presently includes 1007 small hydropower plants (SHPs) having many others under construction or planned. This paper aimed to evaluate changes in water quality, plankton communities, and benthic macroinvertebrates during dam construction, filling, and the first year of operation of a SHP. Suspended solids, turbidity, and silica were variables that highlighted the impact of this construction on the river. Fast changes in water quality (increases in calcium, chlorides, and nitrate) and on aquatic communities (i.e. euglenophyceans and testate amoebae increased in numbers) were detected during the filling phase. Following SHP construction, the concentrations of metals and total phosphorus tended to decrease. Two striking findings observed in the aquatic communities from the riverine conditions to the new lake were the increase in picocyanobacteria abundance, expanding population stocks throughout the river basin, and the constant presence of the invasive mollusc Corbicula fluminea in the macroinvertebrate assemblage, revealing once again its resistance to environmental variability. The lake soon became a natural trap for ions from the drainage basin, as revealed by the increase in electrical conductivity, ammonium, potassium, and magnesium concentrations and the abundance of cyanobacteria, highlighting the need for watershed management to improve ecological conditions in the lake.

Systemic levels of metallic ions released from orthodontic mini-implants.

INTRODUCTION: Orthodontic mini-implants are a potential source of metallic ions to the human body because of the corrosion of titanium (Ti) alloy in body fluids. The purpose of this study was to gauge the concentration of Ti, aluminum (Al), and vanadium (V), as a function of time, in the kidneys, livers, and lungs of rabbits that had Ti-6Al-4V alloy orthodontic mini-implants placed in their tibia. METHODS: Twenty-three New Zealand rabbits were randomly divided into 4 groups: control, 1 week, 4 weeks, and 12 weeks. Four orthodontic mini-implants were placed in the left proximal tibia of 18 rabbits. Five control rabbits had no orthodontic mini-implants. After 1, 4, and 12 weeks, the rabbits were killed, and the selected tissues were extracted and prepared for analysis by graphite furnace atomic absorption spectrophotometry. RESULTS: Low amounts of Ti, Al, and V were detectable in the 1-week, 4-weeks, and 12-weeks groups, confirming that release of these metals from the mini-implants occurs, with diffusion and accumulation in remote organs. CONCLUSIONS: Despite the tendency of ion release when using the Ti alloy as orthodontic mini-implants, the amounts of metals detected were significantly below the average intake of these elements through food and drink and did not reach toxic concentrations.

Mercury distribution in different tissues and trophic levels of fish from a tropical reservoir, Brazil

Concentrations of organic (OrgHg) and inorganic mercury (InorgHg) were assessed in different fish tissues (liver, muscle, kidney, gut and gonads) and trophic levels collected in an impacted tropical reservoir in southeastern Brazil. Organic mercury concentrations in muscle were remarkably higher in the carnivorous species Hoplias malabaricus and Oligosarcus hepsetus. The ratios of OrgHg in relation to total mercury ( percentOrgHg) in muscle also varied according to the species trophic level: 93 percent for carnivores, 84 percent for omnivores, 73 percent for algivores/planktivores and 58 percent for detritivores. The percentOrgHg in the gut tissue of carnivores (78 percent) was much higher than that found in omnivores (30 percent), possibly reflecting a process of trophic biomagnification in the reservoir. On the other hand, the InorgHg concentrations in muscle decreased with the trophic level increase, suggesting that this form of mercury did not biomagnify through the food web. Gonads contained the least total mercury, and approximately all of this mercury was represented by the organic form (83 to 98 percent). The kidney and the liver of all fish species contained less than 50 percent OrgHg. We suggest that the low percentOrgHg in the liver is related to different capacities or strategies of OrgHg detoxification by the fish.(AU)

Concentrações de mercúrio orgânico (OrgHg) e inorgânico (InorgHg) foram avaliadas em diferentes tecidos e níveis tróficos de peixes (fígado, músculo, rim, trato digestivo e gônadas) coletados em um reservatório tropical impactado, no sudeste do Brasil. Concentrações de OrgHg no músculo foram notavelmente maiores em carnívoros (Hoplias malabaricus e Oligosarcus hepsetus). As porcentagens de OrgHg em relação ao mercúrio total ( por centoOrgHg) no músculo também variaram de acordo com o nível trófico das espécies: 93 por cento para os carnívoros, 84 por cento para os onívoros, 73 por cento para os algívoros/planctívoros e 58 por cento para os peixes detritívoros. Além disso, a por centoOrgHg encontrada no trato digestivo dos peixes carnívoros (78 por cento) foi substancialmente superior a encontrada nos onívoros (30 por cento), possivelmente refletindo um processo de biomagnificação trófica no reservatório. Por outro lado, as concentrações de InorgHg no músculo diminuíram com o aumento do nível trófico, sugerindo que esta forma do mercúrio não biomagnificou ao longo da cadeia alimentar. As gônadas apresentaram as menores concentrações de mercúrio total e grande parte deste estava na forma orgânica (83 a 98 por cento). Por outro lado, rins e fígado de todas as espécies de peixes apresentaram menos que 50 por cento de OrgHg. Sugere-se que a baixa por centoOrgHg no fígado possa estar relacionada às diferentes capacidades ou estratégias de destoxificação do OrgHg nesses peixes(AU)

Mapping of quantitative trait loci using the skew-normal distribution / 浙江大学学报（英文版）（B辑：生物医学和生物技术）

In standard interval mapping (IM) of quantitative trait loci (QTL), the QTL effect is described by a normal mixture model. When this assumption of normality is violated, the most commonly adopted strategy is to use the previous model after data transformation. However, an appropriate transformation may not exist or may be difficult to find. Also this approach can raise interpretation issues. An interesting alternative is to consider a skew-normal mixture model in standard IM, and the resulting method is here denoted as skew-normal IM. This flexible model that includes the usual symmetric normal distribution as a special case is important, allowing continuous variation from normality to non-normality. In this paper we briefly introduce the main peculiarities of the skew-normal distribution. The maximum likelihood estimates of parameters of the skew-normal distribution are obtained by the expectation-maximization (EM) algorithm. The proposed model is illustrated with real data from an intercross experiment that shows a significant departure from the normality assumption. The performance of the skew-normal IM is assessed via stochastic simulation. The results indicate that the skew-normal IM has higher power for QTL detection and better precision of QTL location as compared to standard IM and nonparametric IM.