[Characteristics of physiological reactions during long-term immunization of rats with protein conjugates of angiotensin II]. / Osobennosti fiziologicheskikh reaktsii pri dlitel'noi immunizatsii krys belkovymi kon"iugatami angiotenzina II.

The results show that during long-term immunization of rats against conjugates of angiotensin II with bovine serum albumin definite age dynamics of immune response have been observed. It was shown that the changes of physiological readings were correlated with growing of antibodies titer against angiotensin II, accordingly, as the immune response was lower, these readings return to the initial level.

[A comparative analysis of immunoenzyme methods of determining bradykinin]. / Sravnitel'nyi analiz immunofermentnykh metodov opredeleniia bradikinina.

Various modifications of enzyme immunoassay (EIA) for measuring kallikrein-kinin system components (bradykinin, kininogen, kallikrein) are considered. Bradykinin assays are analyzed in detail: double antibodies and competitive solid-phase EIA techniques with the use of various enzymic labels. Special attention is paid to the solid-phase variant in polymeric microplates, the simplest technique that holds good promise for clinical application. The authors have used this method for bradykinin measurements and tried to improve its sensitivity.

[The production of specific antisera to bradykinin and their study by immunoenzyme analysis]. / Poluchenie spetsificheskikh antisyvorotok k bradikininu i ikh issledovanie metodom immunofermentnogo analiza.

Bradykinin coupled to bovine serum albumin or to rabbits erythrocytes was used to immunize rabbits. It was shown that enzyme-linked immunosorbent assay (ELISA) has been successfully used for the investigation of the obtained immune sera.