[Significance of catecholamine levels in the diagnosis and prognosis of dysadaptation of preterm newborn infants]. / Znachenie pokazatelei katekholaminov dlia diagnostiki i prognoza dizadaptatsii u nedonoshennykh novorozhdennykh.

Analysis of the clinical status of preterm newborns and the results of histochemical studies of the red cell catecholamine depositing function has led the authors to a conclusion that the Apgar score is reliable only in case of the newborn's critical condition. In slight and medium-severity asphyxia high red cell satiation with catecholamine granules was associated with a favorable outcome for the newborns. The authors claim that analysis of red cell catecholamine-depositing function is a sufficiently reliable diagnostic and prognostic criterion for the assessment of a preterm newborn's status.

[Cardiac rhythm in healthy newborn infants and in infants from the risk group in the early neonatal period]. / Ritm serdtsa zdorovykh novorozhdennykh i detei gruppy riska v rannem neonatal'nom periode.

Studies of heart rhythm parameters, carried out in 88 healthy newborns and in 117 risk-group babies over the course of the early neonatal period (starting from the second minute and up to the seventh day of life) helped derive the normal values of heart rhythm and determine the time characteristics of regulation mechanism establishment in the early postnatal ontogenesis: from sympathetic tonus and centralization of heart rhythm control in the first hours of life to augmenting parasympathetic tonus and autoregulation. Prenatal risk factors were found conducive to deceleration of the newborn's adaptive reactions even when no clinical symptoms of neonatal abnormalities are detectable. The feeding (sucking) process in health is associated with elevation of cholinergic activity of the autonomic nervous system; this phenomenon underlies the method for assessment of the newborn's adaptation (feeding test). The metabolic parameters are less informative in assessment of postnatal adaptation efficacy as against heart rhythm parameters.

[Clinico-biological evaluation of the status of newborn infants and the tactics in the management of the early postnatal period]. / Kliniko-biologicheskaia otsenka sostoianiia detei pri rozhdenii i taktika vedeniia rannego postnatal'nogo perioda.

Biology of the perinatal period as a basis of neonatal management is an area of conceptual controversy. Literature evidence and findings of a clinical and functional study in 175 term newborns support the concept of intrapartum and neonatal stress. This is a rationale for a strategy of maintaining the adaptive mechanisms of the fetus and newborn in a maximal range and active support of neonatal homeostasis. Narcotic depression, prolonged hypothermia++ of various origins are considered as factors endangering the postnatal adaptation.

[Habitual abortion as a high risk factor for the formation of perinatal pathology and disorders of psychomotor development in children]. / Privychnoe nevynashivanie kak faktor vysokogo riska formirovaniia perinatal'noi patologii i narusheniia psikhomotornogo razvitiia detei.

With the aim to analyse the patterns and incidence of perinatal abnormalities, the history of pregnancy and the course of labour were studied in 400 recurrent spontaneous abortion cases. The course of the early neonatal period of these mothers' newborns was investigated and the follow-up history of 50 infants of this group was analysed. The findings indicated a high (62.8 per cent) incidence of perinatal damage in the studied group. The early neonatal period in the newborns was characterized by maladaptation and increased vulnerability followed by impairment of the mental and physical development.

[A period of urgent postnatal adaptation as a critical stage of human ontogenesis]. / Period ékstrennoi postnatal'noi adaptatsii kak kriticheskii étap ontogeneza cheloveka.

The infant's state immediately after delivery is characterized by critical shifts of homeostasis parameters: decompensated mixed acidosis, pathologic indices of gaseous blood condition (arterial hypoxemia and hypercapnia), spontaneous postnatal hypothermia. Qualitative change of functional systems after delivery is accompanied by expressed tense of adaptation and regulation mechanisms and by centralization of cardiac rhythm control. The use of mathematical analysis of cardiac rhythm made it possible to find out that the change of degree of adaptation tense in the process- of postnatal period obeys the exponential dependence; moreover, the duration of transitional process of healthy newborns is 1 hour, but it considerably increases in case of hypoxia. After comparison of cardiac rhythm indices of these two groups of newborns it has been pointed out that mechanisms of adaptation after delivery are equal and they are based on the growing activity of central regulation processes. The dynamics of transitional process such as the period of postnatal adaptation indicates the reserve possibilities of infant and helps to reveal pre-nosological forms of disadaptational syndrome.