Boosted acceleration of protons by tailored ultra-thin foil targets.

We report on a detailed experimental and numerical study on the boosted acceleration of protons from ultra-thin hemispherical targets utilizing multi-Joule short-pulse laser-systems. For a laser intensity of 1 × 1020 W/cm2 and an on-target energy of only 1.3 J with this setup a proton cut-off energy of 8.5 MeV was achieved, which is a factor of 1.8 higher compared to a flat foil target of the same thickness. While a boost of the acceleration process by additionally injected electrons was observed for sophisticated targets at high-energy laser-systems before, our studies reveal that the process can be utilized over at least two orders of magnitude in intensity and is therefore suitable for a large number of nowadays existing laser-systems. We retrieved a cut-off energy of about 6.5 MeV of proton energy per Joule of incident laser energy, which is a noticeable enhancement with respect to previous results employing this mechanism. The approach presented here has the advantage of using structure-wise simple targets and being sustainable for numerous applications and high repetition rate demands at the same time.

Oligonucleotide and Parylene Surface Coating of Polystyrene and ePTFE for Improved Endothelial Cell Attachment and Hemocompatibility.

In vivo self-endothelialization by endothelial cell adhesion on cardiovascular implants is highly desirable. DNA-oligonucleotides are an intriguing coating material with nonimmunogenic characteristics and the feasibility of easy and rapid chemical fabrication. The objective of this study was the creation of cell adhesive DNA-oligonucleotide coatings on vascular implant surfaces. DNA-oligonucleotides immobilized by adsorption on parylene (poly(monoaminomethyl-para-xylene)) coated polystyrene and ePTFE were resistant to high shear stress (9.5 N/m(2)) and human blood serum for up to 96 h. Adhesion of murine endothelial progenitor cells, HUVECs and endothelial cells from human adult saphenous veins as well as viability over a period of 14 days of HUVECs on oligonucleotide coated samples under dynamic culture conditions was significantly enhanced (P < 0.05). Oligonucleotide-coated surfaces revealed low thrombogenicity and excellent hemocompatibility after incubation with human blood. These properties suggest the suitability of immobilization of DNA-oligonucleotides for biofunctionalization of blood vessel substitutes for improved in vivo endothelialization.