ABSTRACT
The calcium antagonists verapamil and nifedipine were shown to attenuate the development of carrageenin-induced rat paw inflammatory edema. Oral nifedipine exerted more pronounced antiedematous dose-dependent effects.
Subject(s)
Edema/drug therapy , Nifedipine/therapeutic use , Verapamil/therapeutic use , Animals , Carrageenan , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Edema/chemically induced , Foot , Inflammation/chemically induced , Inflammation/drug therapy , Rats , Time FactorsSubject(s)
Benzene/blood , Rubber , Shoes , Animals , Dose-Response Relationship, Drug , Environmental Exposure , Female , Humans , Occupational Medicine , Pregnancy , Rats , USSRABSTRACT
Characteristics of nervous processes were studied in 50 pairs of twins by the verbal motor method with a preliminary verbal instruction. A chronographic reflexmeter with programmed control was used. Statistical processing of the data and calculation of heredity coefficients by the Holsinger formula has shown that the average intrapair difference in monozygotic twins (MT) was, as a rule, smaller than in dizygotics (DT). Dispersion analysis revealed a considerable dispersion of resultative characters in DT as compared with MT. The heredity coefficients obtained for the strength of the inhibitory process (H=0.88), that of the excitatory process (H=0.50), the mobility of nervous processes (H=0.42) and the rate of conditioning (H=0.34) points to a considerable genotypic determination of the examined properties of nervous processes.
