[Pathogenetic basis for the use of GABA-ergic preparations in combination with atropine during chronic pain syndrome in patients with neurologic manifestations of lumbar osteochondrosis]. / Patogeneticheskoe obosnovanie primeneniia GAMK-ergicheskikh preparatov v sochetanii s atropinom pri khronicheskom bolevom sindrome u bol'nykh s nevrologicheskimi proiavleniiami poiasnichnogo osteokhondroza.

The intensity of neuronal uptake of 3H- or 14C-labeled GABA, glycine, noradrenaline, choline and glucocorticoid receptor binding were investigated in different structures of the rabbit CNS by simulating chronic pain syndrome. Data obtained allow to suggest pathogenetically justified therapy including the complexes of phenybute + atropine and relanium + atropine. The contents of Leu-Enkephaline, cortisol, insuline and insuline/cortizole ratio were studied in the blood serum of the patients with neurological manifestations of lumbar osteochondrosis and a long case history of the pain treated by the above mentioned complexes. The proposed therapeutical approach allowed to achieve pronounced antistress effect and regression of the pain syndrome due to stimulation of the CNS endogenic antinociceptive structures. It was shown that stress-produced hormones and opioids ratio in the blood serum may serveas indirect criteria of the functional activity of the endogenic antinociceptive structures before and after the treatment.

[Function of the hypothalamo-thyroid system after administration of kainate into the ventrolateral portion of the medulla oblongata]. / Funktsiia sistemy gipotalamus--shchitovidnaia zheleza posle vvedeniia kainata v ventrolateral'nyi otdel prodolgovatogo mozga.

Contribution of the bulbar structures to mechanisms of realization of the hypothalamo-thyroid system feedback was studied in experiments on 73 adult male Wistar rats. Histologically confirmed unilateral destruction of neurones in the caudal part of medulla oblongata ventral portions after injection of 0.65 micrograms of kainate as soon as 30 min after injection was paralleled by a trend to increase of the blood serum levels of triiodothyronine and thyroxin-binding globulin, this increase attaining reliable values by day 7 after destruction, when the effects of operation stress levelled. During the same period we observed activation of glucocorticoid-dependent choline-, serotonin-, and noradrenergic-processes in the mediobasal zone of the hypothalamus, this indicating the presence of functional relationships of medulla oblongata ventral portions with the hypothalamo thyroid system realized by disinhibition of this system during destruction of neurones in the caudal part of the ventral portion of medulla oblongata.

[Neurotransmitter balance in the CNS structure as effected by the combination of ionizing radiation and various doses of lead acetate]. / Neiromediatornyi balans v strukturakh TsNS pri sochetannom vozdeistvii ioniziruiushchei radiatsii i razlichnykh doz atsetata svintsa.

In experiments with mature Wistar male rats exposed to 25- and 50-fold fractionated doses of external X-ray radiation (0.5 Gy) and daily probe-assisted administration of plumbum acetate (100, 10, 5 mg/kg), similar, but differently marked changes in transmitter relationship in some CNS structures resembling the earlier found neurotransmitter disbalance during chronic stress of different ethiology were revealed. Combined exposure to plumbum and radiation led to more sustained and prolonged disorders to transmitter relationship associated with a sharp decrease in specific binding of corticosterone in CNS glucocorticoid-sensitive structures.

[Function of the hypothalamus-thyroid system long after radiation and neurotropin correction of the disorders detected]. / Funktsiia sistemy gipotalamus-shchitovidnaia zheleza v otdalennye sroki posle oblucheniia i korrektsiia vyiavlennykh narushenii neirotropinom.

In experiments on Wistar male rats exposed to single X-ray radiation 0.5 Gy and combination of X-ray 0.5 Gy and 131I 6.5 microCi/kg inhibition of activity of excitatory and inhibitory neurotransmitter processes in the mediobasal hypothalamus was observed 6 months after radiation. This was accompanied by a prolonged hypofunction of the thyroid gland related to disorders with glandular stromal follicles and secretion of hormones into the bloodstream. Application of neurotropin that normalizes to a certain extent the transmitter relationship in the hypothalamus does not act positively on the thyroid functional activity. All this indicates a necessity of combined correction of the disorders found not only with neurotropic drugs but also with directional therapy of the affected organs and systems.

[Intracerebral connections after administration of kainate into the caudal part of ventral sections of the medulla oblongata]. / Vnutrimozgovye sviazi posle vvedeniia kainata v kaudal'nuiu chast' ventral'nykh otdelov prodolgovatogo mozga.

It was found that 1 day after unilateral destruction with kainate of neurons in the caudal ventral medulla unanesthetized animals showed disorders of arterial pressure control with a prevalence of hypertensive response. In 7 days after operation there was a decrease in the rate of neuronal uptake of serotonin and an increase in choline-, dopamine-, noradrenaline-, and glycinergic mediation in the basal hypothalamus and rostral ventral medulla, which characterize the functional state of synaptic formations in the brain stem structures connected to neurons in the caudal ventral medulla and involved in cardiovascular regulation.

[Modifying effects of neurotropin on post-radiation disorders of neuromediator processes in the autonomic function regulation centers]. / Modifitsiruiuschchie éffekty neirotropina na postluchevye narusheniianeiromediatornykh protsessov v tsentrakh reguliatsii vegetativnykh funktsii.

In experiments on Wistar rats, it was shown that 6 months after exposure to ionizing radiation (X-radiation 0.5 Gy and intraperitoneal 131I 6.5 mCu/kg) the hypothyroid state was accompanied by changes in inhibitory and excitatory mediation that are characteristic of chronic radiation stress in cerebral structures responsible for regulation of autonomic and animal functions and a relative deficiency of the hypothalamopituitary-adrenocortical axis. Application of therapeutic doses of neurotropin 3 months after radiation levelled the pattern of chronic radiation stress and diencephalic disorders that underlie disturbances of some systemic functions of the organism.

[Glucocorticoid control of the mediator process in the brain structures during immediate adaptation]. / Gliukokortikoidnyi kontrol' mediatornykh protsessov v strukturakh golovnogo mozga pri srochnoi adaptatsii.

In male rats with a high and low blood levels of corticosterone, the activity of serotonin-, dopamine-, noradrenaline-, glycine, GABA-, and cholinergic processes was shown to depend on the glycocorticoid content in the organism and receptor binding of 3H-corticosterone in different brain structures. The formation of adequate processes of neurotransmitter adaptation to a short-term vibration is only possible at a fairly high level of glycocorticoids in the organism.

[The role of glucocorticoids in the post-vibration changes in inhibition mediation in the brain structures]. / Rol' gliukokortikoidov v postvibratsionnykh sdvigakh tormoznoi mediatsii v strukturakh golovnogo mozga.

Low-frequency vertical vibration for 2 hours together with three-fold increase of glucocorticoids is accompanied by the disruption of typical relationships of neuromediator processes (norepinephrine- and serotoninergic mediation) as well as the reduction of the intensity of choline trapping with glucocorticoid perception. Glucocorticoid-related conformation changes in plasma membranes and a drastic increase of the cAMP level provide plasticity of both nonspecific (hypothalamus, raphe bluish sites and nuclei) and specific (Deiters' nuclei) structures. The relationships of neuromediator processes in different CNS structures depend on the content of glucocorticoids. This should be taken into consideration when developing pathogenetically adequate methods for restoring the vestibular component of the motion sickness syndrome.

[Mediator processes in the brain structures in the late periods after external and combined exposure to ionizing radiation]. / Mediatornye protsessy v strukturakh golovnogo mozga v otdalennye sroki posle vneshnego i sochetannogo vozdeistviia ioniziruiushchei radiatsii.

In experiments with mature Wistar male rats it was shown that X-radiation of 12.9 mCi/kg and the combined effect of X-rays and 131I of 6.5 mCi/kg changed the rate of mediator processes in the structures responsible for the hypothalamic function regulation. At remote times (6 months) following irradiation differences were observed in the discoordination of mediator interrelations associated with the peculiarities of the indirect effect of external and combined irradiation implemented via endocrine mechanism system.

[Early effects of the influence of ionizing radiation in relatively small doses on the neuromediator systems responding to the central regulation of the hypothalamo-pituitary-adrenal cortex system]. / Rannye éffekty vliianiia ioniziruiushchei radiatsii v otnositel'no nebol'shikh dozakh na neiromediatornye sistemy, otvetstvennye za tsentral'nuiu reguliatsiiu gipotalamo-gipofiz-adrenokortikal'noi sistemy.

In experiments with mature Wistar male rats changes of mediator interrelations in different brain parts, responsible for the central regulation of the hypothalamo-pituitary-adrenocortical system, were detected at early times after whole-body X-irradiation with a dose of 12.9 mC/kg. These changes represent one of the major mechanisms leading, at later times after irradiation, to the development of syndromes related to diencephalic disturbances.