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1.
Worm ; 2(1): e24690, 2013 Jan 01.
Article in English | MEDLINE | ID: mdl-24058865
2.
Worm ; 2(2): e25024, 2013 Apr 01.
Article in English | MEDLINE | ID: mdl-24058876
3.
Mob Genet Elements ; 3(1): e24559, 2013 Jan 01.
Article in English | MEDLINE | ID: mdl-23734301
4.
Adipocyte ; 2(1): 1-2, 2013 Jan 01.
Article in English | MEDLINE | ID: mdl-23700545
5.
Small GTPases ; 4(1): 1-2, 2013 Jan 01.
Article in English | MEDLINE | ID: mdl-23646280
6.
Mob Genet Elements ; 2(5): 203-204, 2012 Sep 01.
Article in English | MEDLINE | ID: mdl-23447802
7.
Adipocyte ; 1(1): 2-3, 2012 Jan 01.
Article in English | MEDLINE | ID: mdl-23700506
8.
Adipocyte ; 1(4): 189-191, 2012 Oct 01.
Article in English | MEDLINE | ID: mdl-23700532
9.
Worm ; 1(4): 187-8, 2012 Oct 01.
Article in English | MEDLINE | ID: mdl-24058846
10.
Mol Cell Neurosci ; 31(2): 334-45, 2006 Feb.
Article in English | MEDLINE | ID: mdl-16278083

ABSTRACT

We overexpressed a constitutively active form of the neuregulin receptor ErbB2 (CAErbB2) in skeletal muscle fibers in vivo and in vitro by tetracycline-inducible expression. Surprisingly, CAErbB2 expression during embryonic development was lethal and impaired synaptogenesis yielding a phenotype with loss of synaptic contacts, extensive axonal sprouting, and diffuse distribution of acetylcholine receptor (AChR) transcripts, reminiscent of agrin-deficient mice. CAErbB2 expression in cultured myotubes inhibited the formation and maintenance of agrin-induced AChR clusters, suggesting a muscle- and not a nerve-origin for the defect in CAErbB2-expressing mice. Levels of tyrosine phosphorylated MuSK, the signaling component of the agrin receptor, were similar, while tyrosine phosphorylation of AChRbeta subunits was dramatically reduced in CAErbB2-expressing embryos relative to controls. Thus, a gain-of-function manipulation of ErbB2 signaling pathways renders an agrin-deficient-like phenotype that uncouples MuSK and AChR tyrosine phosphorylation.


Subject(s)
Muscle, Skeletal/cytology , Muscle, Skeletal/embryology , Neuromuscular Junction/embryology , Receptor, ErbB-2/metabolism , Synapses/physiology , Agrin/genetics , Agrin/metabolism , Animals , Mice , Mice, Transgenic , Muscle, Skeletal/metabolism , Neuromuscular Junction/metabolism , Protein Isoforms/genetics , Protein Isoforms/metabolism , Receptor Protein-Tyrosine Kinases/genetics , Receptor Protein-Tyrosine Kinases/metabolism , Receptor, ErbB-2/genetics , Receptors, Cholinergic/genetics , Receptors, Cholinergic/metabolism , Signal Transduction/physiology , Tyrosine/metabolism
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