ABSTRACT
Scrotal trauma is often mentioned as a cause of testicular atrophy yet there have been few studies documenting the effect of scrotal trauma on testicular size months or years following injury. We performed clinical and sonographic examinations in 10 patients who had suffered blunt scrotal trauma. A significant reduction in volume of the injured testis was observed in 5/10 cases at follow-up sonography. In two cases the affected testis was heterogeneous and colour flow Doppler examination showed reduced flow. In three cases the testis was homogeneous but reduced in volume and in the remaining five cases the affected testis appeared normal. We conclude that testicular atrophy is a sequel of scrotal trauma and occurred in 50% of patients in this study.
Subject(s)
Scrotum/injuries , Testis/pathology , Adolescent , Adult , Atrophy/diagnostic imaging , Atrophy/etiology , Follow-Up Studies , Humans , Male , Middle Aged , Scrotum/diagnostic imaging , Testis/diagnostic imaging , Ultrasonography, Doppler, Color , Wounds, Nonpenetrating/complications , Wounds, Nonpenetrating/diagnostic imagingABSTRACT
Cobalamin metabolism has been investigated in a new case of transcobalamin II (TC II) deficiency. Using the chromatobioautographic technique, an abnormal distribution of cobalamins was detected in the child's erythrocytes and reduced synthesis of adenosylcobalamin but not of methylcobalamin in cultured fibroblasts. These results suggest that there may be a close link between TC II-mediated cobalamin transport and intracellular synthesis of adenosylcobalamin (Ado-Cbl).
Subject(s)
Blood Proteins/deficiency , Cobamides/biosynthesis , Infant, Newborn, Diseases/metabolism , Transcobalamins/deficiency , Vitamin B 12/isolation & purification , Amino Acid Metabolism, Inborn Errors/metabolism , Biological Transport , Humans , Infant , Infant, Newborn , Male , Vitamin B 12/bloodABSTRACT
Detecting a high titre of antibody directed against the cytoplasm of malignant melanoma cells can help: To diagnose pigmented skin lesions with awkward histopathological signs. The test is positive in about half of the early primary malignant melanomas and in all actively regressing halo naevi. It is negative in benign juvenile melanoma. To prognosticate and provide a continuing assessment of the course of the disease in patients with known malignant melanoma. The test becomes negative when malignant melanoma metastasizes. To alert patients in danger, such as those who have extensive pigmented naevi or have a family history of malignant melanoma, of the supervention of the disease.
