ABSTRACT
The CHOIR and CREATE studies led to changes in hemoglobin targets around the world for patients with chronic kidney disease. The aim of this study was to determine what effect these pivotal studies had on hemoglobin levels and survival Data were extracted from Australia's Renal Anaemia Database for patients with chronic kidney disease between October 2000 and December 2009. Survival was significantly longer in patients with chronic kidney disease who died between 2007 and 2009 compared to those who died between 2000 and 2006.
Subject(s)
Anemia/complications , Kidney Failure, Chronic/physiopathology , Australia , Database Management Systems , Female , Humans , Kidney Failure, Chronic/complications , Male , Survival RateABSTRACT
BACKGROUND: Indigenous Australians have significantly higher rates of end-stage renal disease and worse health outcomes than non-indigenous Australians. OBJECTIVES: We investigated whether the effect of inflammation on C-reactive protein (CRP) and ferritin levels is being overlooked in indigenous patients with chronic kidney disease. DESIGN: Data for 23,000 patients were extracted from the Renal Anaemia Management database for the period November 1999 to October 2010. MEASUREMENT: Haemoglobin, ferritin, transferrin saturation and CRP levels for indigenous and non-indigenous Australians were compared with target levels given in the Caring for Australians with Renal Impairment (CARI) guidelines. RESULTS: Compared with non-indigenous patients, indigenous Australians had higher median CRP and mean ferritin levels, lower mean haemoglobin level and were less likely to meet CARI targets. CONCLUSION: The effect of inflammation on laboratory parameters should be considered particularly when treating indigenous Australians.
