Assessing Knowledge and Use Practices of Plastic Food Packaging among Young Adults in South Africa: Concerns about Chemicals and Health.

Chemicals associated with health problems can migrate from packaging into food matrices. Therefore, consumers need to be aware of health concerns associated with incorrectly used plastic food packaging. However, little is known about consumers' knowledge and their plastics usage practices. This study assessed this knowledge and practices among young South African adult consumers. Our online survey of 293 participants focused on their objective (actual) and subjective (self-perceived) knowledge about plastic food packaging care and safety, their utilization practices, and their sources of information about safe use of plastics. Participants' utilization practices showed broad misuse. Their subjective knowledge about the correct use of plastic packaging was in most respects contradicted by their limited objective knowledge. We found that plastic identification codes on packaging largely failed in their informative purpose; instead, participants mainly consulted informal information sources about plastics. The knowledge gaps, unsafe plastic use practices, and information source deficiencies identified here can help to guide future improvements. We call for consumer education, across all demographics, about plastic utilization practices and associated health concerns about plastic chemicals. We also highlight the need for the government, food and plastics industries to join forces in ensuring that consumers are informed about safe plastic packaging usage.

Long-term effects of pre-pubertal fluoxetine on behaviour and monoaminergic stress response in stress-sensitive rats.

OBJECTIVE: Although prescription rates of antidepressants for children and adolescents have increased, concerns have been raised regarding effects on neurodevelopment and long-term outcome. Using a genetic animal model of depression, this study investigated the long-term effects of pre-pubertal administration of fluoxetine (FLX) on depressive-like behaviour in early adulthood, as well as on central monoaminergic response to an acute stressor. We postulated that pre-pubertal FLX will have lasting effects on animal behaviour and monoaminergic stress responses in early adulthood. METHODS: Flinders sensitive line (FSL) rats received 10 mg/kg/day FLX subcutaneously from postnatal day 21 (PnD21) to PnD34 (pre-pubertal). Thereafter, following normal housing, rats were either subjected to locomotor testing and the forced swim test (FST) on PnD60 (early adulthood), or underwent surgery for microdialysis, followed on PnD60 by exposure to acute swim stress and measurement of stressor-induced changes in plasma corticosterone and pre-frontal cortical monoamine concentrations. RESULTS: Pre-pubertal FLX did not induce a late emergent effect on immobility in FSL rats on PnD60, whereas locomotor activity was significantly decreased. Acute swim stress on PnD60 significantly increased plasma corticosterone levels, and increased pre-frontal cortical norepinephrine (NE) and 5-hydroxyindole-3-acetic acid (5-HIAA) concentrations. Pre-pubertal FLX significantly blunted the pre-frontal cortical NE and 5-HIAA response following swim stress on PnD60. Baseline dopamine levels were significantly enhanced by pre-pubertal FLX, but no further changes were induced by swim stress. CONCLUSION: Pre-pubertal FLX did not have lasting antidepressant-like behavioural effects in genetically susceptible, stress-sensitive FSL rats. However, such treatment reduced locomotor activity, abrogated noradrenergic and serotonergic stressor responses and elevated dopaminergic baseline levels in adulthood.