ABSTRACT
AIM: To study 5-aminosalicylate nephrotoxicity in patients with inflammatory bowel disease in the UK. METHODS: A detailed postal questionnaire was sent to all 1298 names in the British Society of Gastroenterology database and 290 consultant members of the Renal Association. The British Society of Gastroenterology reported new cases monthly, the Renal Association 6 monthly. Results were expressed as estimated glomerular filtration rate. RESULTS: Retrospective study: cases--British Society of Gastroenterology:Renal Association 202:87, aged 15-76 years. Median peak (range) creatinine (British Society of Gastroenterology:Renal Association) - 300:301 (78-1200) micromol/L. Prospective study - 59 cases, median age 52 years (M:F ratio: 47:12). Median pre-treatment estimated glomerular filtration rate: 76.9 (123.9-39), at diagnosis 28.4 (80.5-3.6, creatinine range: 92-1361 micromol/L), recovery 46.8 [111.2-end stage renal failure] mL/min/1.73 m2. Recovery of renal function was significantly improved for patients treated for < 12 months [n = 10, median recovery estimated glomerular filtration rate 70.5 (92-26.9) vs. > 12 months 38.4 (111.2-end stage renal failure) mL/min/1.73 m2, P = 0.028]. CONCLUSIONS: Regular monitoring of renal function may allow earlier detection of nephrotoxicity, particularly during the first year of therapy. Based on an inflammatory bowel disease prevalence in the United Kingdom of 412 x 10(5) with about 50% on treatment, we estimate that the incidence of clinical nephrotoxicity in patients taking 5-aminosalicylate therapy is approximately one in 4000 patients/year.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Kidney Diseases/chemically induced , Mesalamine/adverse effects , Adult , Aged , Aged, 80 and over , Drug Monitoring , Epidemiologic Methods , Female , Glomerular Filtration Rate/drug effects , Humans , Kidney/physiopathology , Kidney Diseases/epidemiology , Kidney Diseases/pathology , Male , Middle Aged , United Kingdom/epidemiologyABSTRACT
Fifty-one patients were analyzed after a randomized double-blind study comparing Hexabrix and Renografin 60 in peripheral arteriography. The arteriographic studies and the volumes of contrast material used in both groups were similar. Hexabrix caused significantly less pain and discomfort than Renografin 60, and the diagnostic quality of the radiographs was comparable. A slightly higher incidence of minor side effects was noted in the Hexabrix group, mostly nausea and vomiting and urinary retention.
Subject(s)
Angiography , Contrast Media , Diatrizoate Meglumine , Diatrizoate/analogs & derivatives , Iodobenzoates , Triiodobenzoic Acids , Angiography/adverse effects , Clinical Trials as Topic , Contrast Media/adverse effects , Diatrizoate/adverse effects , Diatrizoate Meglumine/adverse effects , Double-Blind Method , Drug Combinations/adverse effects , Female , Humans , Ioxaglic Acid , Male , Pain/etiology , Triiodobenzoic Acids/adverse effectsABSTRACT
Gastrostomies have been performed nonoperatively under local anaesthesia using a simultaneous percutaneous and endoscopic approach. This technique has been modified to be done under fluoroscopy without the need for endoscopy. The technique and results in five dogs are described.
Subject(s)
Gastrostomy/methods , Animals , Dogs , FluoroscopyABSTRACT
Fifty-one patients were analyzed after a randomized double-blind study comparing Hexabrix and Renografin 60 in peripheral arteriography. The arteriographic studies and the volumes of contrast material used in both groups were similar. Hexabrix caused significantly less pain and discomfort than Renografin 60, and the diagnostic quality of the radiographs was comparable. A slightly higher incidence of minor side effects was noted in the Hexabrix group, mostly nausea and vomiting and urinary retention.
Subject(s)
Angiography , Arterial Occlusive Diseases/diagnostic imaging , Contrast Media , Diatrizoate Meglumine , Diatrizoate , Iodobenzoates , Triiodobenzoic Acids , Diatrizoate/adverse effects , Diatrizoate/analogs & derivatives , Diatrizoate Meglumine/adverse effects , Double-Blind Method , Drug Combinations/adverse effects , Female , Humans , Iodobenzoates/adverse effects , Ioxaglic Acid , Male , Pain/etiology , Random Allocation , Triiodobenzoic Acids/adverse effectsABSTRACT
A horizontal lucent line projecting over a cervical vertebral body on lateral radiographs and simulating a fracture is described. The pseudofracture line results from the lucency between contiguous proliferative osteophytes at the uncinate process/vertebral articulation. Associated disc space narrowing was seen in all of our eleven cases. The origin of this pseudofracture line, cases illustrating this phenomenon, and additional projections helpful for clarification are presented.
Subject(s)
Cervical Vertebrae/diagnostic imaging , Fractures, Bone/diagnostic imaging , Fractures, Closed/diagnostic imaging , Aged , Cervical Vertebrae/injuries , Diagnosis, Differential , Female , Humans , Male , Middle Aged , RadiographyABSTRACT
A patient with Klinefelter's syndrome and breast carcinoma with multiple metastases, positive for both estrogen and progesterone receptors, showed documented regression of a lung and bone lesion after chemotherapy and a trial of tamoxifen therapy.
