ABSTRACT
Detailed post-mortem is crucial in infants who die suddenly and without a known cause. We report a rare case of histiocytoid cardiomyopathy with endocardial fibroelastosis, the second case in the world literature. The infant presented with sudden death, but the cardiac histological appearance was initially believed to be caused by Pompes disease.
Subject(s)
Cardiomyopathy, Hypertrophic/pathology , Death, Sudden, Cardiac/etiology , Glycogen Storage Disease Type II/diagnosis , Histiocytosis/pathology , Autopsy , Cardiomyopathy, Hypertrophic/complications , Diagnosis, Differential , Female , Glycogen Storage Disease Type II/complications , Histiocytosis/complications , Humans , InfantSubject(s)
Giant Cell Arteritis/complications , Raynaud Disease/etiology , Aged , Anti-Inflammatory Agents/pharmacology , Female , Giant Cell Arteritis/drug therapy , Giant Cell Arteritis/pathology , Humans , Prednisolone/pharmacology , Raynaud Disease/drug therapy , Raynaud Disease/pathology , Treatment OutcomeABSTRACT
One hundred and eighty-one cases of squamous carcinoma of the uterine cervix, which had been retrieved from the archives of Aberdeen Royal Hospital, from 1974 to 1988, were stained with periodic acid-Schiff following diastase and alcian blue to ascertain the value and prognostic significance of demonstrating the presence of mucin. Each case was typed and graded on a representative haematoxylin and eosin section, while the age at diagnosis, stage and survival (within a minimum five year follow-up) was obtained from examination of hospital case notes and death certificates. The data was analysed by Cox regression which revealed that the demonstration of mucin, either by both stains or only one method, had no bearing on prognosis. On this basis, it is concluded that routine mucin staining of squamous carcinomas of the uterine cervix is not justified.
Subject(s)
Biomarkers, Tumor/analysis , Carcinoma, Adenosquamous/pathology , Carcinoma, Squamous Cell/pathology , Mucins/analysis , Uterine Cervical Neoplasms/pathology , Carcinoma, Adenosquamous/chemistry , Carcinoma, Adenosquamous/mortality , Carcinoma, Squamous Cell/chemistry , Carcinoma, Squamous Cell/mortality , Female , Humans , Prognosis , Staining and Labeling , Uterine Cervical Neoplasms/chemistry , Uterine Cervical Neoplasms/mortalityABSTRACT
Epidermal growth factor (EGF) receptor expression was estimated in 50 invasive human colorectal cancers using immunohistochemistry and the degree of expression was quantified from integrated optical density measurements on the stained sections. All tumours stained positively, but Dukes' C tumours exhibited significantly higher levels of receptor than either Dukes' A or B tumours. In addition, histologically high grade cancers expressed receptors more strongly than those of low grade. It is concluded that a high EGF receptor concentration is associated with poor prognostic factors in colorectal malignancy.
