Subject(s)
Diagnostic Imaging , Hodgkin Disease/diagnosis , Adolescent , Child , Child, Preschool , Combined Modality Therapy , Disease-Free Survival , Female , Hodgkin Disease/mortality , Hodgkin Disease/pathology , Hodgkin Disease/therapy , Humans , Male , Neoplasm Staging , Predictive Value of Tests , PrognosisSubject(s)
Hodgkin Disease/pathology , Adolescent , Adult , Aged , Aged, 80 and over , Child , Diagnostic Imaging , Female , Hodgkin Disease/diagnosis , Humans , Male , Middle Aged , Neoplasm Staging , Predictive Value of Tests , PrognosisSubject(s)
Diagnostic Imaging , Hodgkin Disease/diagnosis , Adolescent , Adult , Combined Modality Therapy , Female , Follow-Up Studies , Hodgkin Disease/mortality , Hodgkin Disease/therapy , Humans , Male , Middle Aged , Neoplasm Recurrence, Local/diagnosis , Neoplasm Recurrence, Local/mortality , Neoplasm Recurrence, Local/therapy , Neoplasms, Second Primary/diagnosis , Neoplasms, Second Primary/mortality , Neoplasms, Second Primary/therapy , Predictive Value of Tests , Survival Rate , Treatment OutcomeABSTRACT
Recent refinements in the multimodal therapy of childhood genitourinary rhabdomyosarcoma have produced striking improvements in long-term survival rates while still preserving pelvic organ function in the majority of cases. Three illustrative cases of childhood pelvic rhabdomyosarcoma are presented. Chemotherapy and surgical staging are employed in all 3 cases, with 2 of the cases requiring additional local tumor excision and intraurethral radiation for control of residual microscopic tumor. While long-term follow-up has not been achieved, all 3 patients have had their pelvic organs preserved and remain tumor-free in follow-up periods ranging from twelve to twenty-four months after the initial diagnosis.
Subject(s)
Rhabdomyosarcoma/therapy , Urogenital Neoplasms/therapy , Child, Preschool , Female , Humans , Infant , Male , Prostatic Neoplasms/mortality , Prostatic Neoplasms/therapy , Rhabdomyosarcoma/mortality , Urethral Neoplasms/mortality , Urethral Neoplasms/therapy , Urinary Bladder Neoplasms/mortality , Urinary Bladder Neoplasms/therapy , Vaginal Neoplasms/mortality , Vaginal Neoplasms/therapyABSTRACT
Eighty-one patients with preinvasive carcinoma of the vocal cord, seen over a thirteen year period, were reviewed histologically and analyzed for response to treatment. Sixty-seven cases were clinically T1 and fourteen cases T2 (by virtue of extension of disease beyond the vocal cord). All patients had mobile cords. Histological criteria for in situ carcinoma and the spectrum of microscopic patterns are presented. Sixty-nine patients were treated by external beam radiotherapy--the remainder by a variety of surgical procedures. Five and ten year actuarial, recurrence-free rates 83% and 75%, respectively for the group treated by irradiation. No difference in local control was observed when analyzed for: 1) dose response, 2) initial extent of disease, 3) treatment plan, or 4) histologic diagnosis. Analysis of failures reveals that 15/17 patients with local failure were salvaged, eleven of these patients requiring laryngectomy. Time to appearance of recurrence ranged from seven to one hundred and seven months.
