Artificial Intelligence-Driven Radiomics in Head and Neck Cancer: Current Status and Future Prospects.

BACKGROUND: Radiomics is a rapidly growing field used to leverage medical radiological images by extracting quantitative features. These are supposed to characterize a patient's phenotype, and when combined with artificial intelligence techniques, to improve the accuracy of diagnostic models and clinical outcome prediction. OBJECTIVES: This review aims at examining the application areas of artificial intelligence-based radiomics (AI-based radiomics) for the management of head and neck cancer (HNC). It further explores the workflow of AI-based radiomics for personalized and precision oncology in HNC. Finally, it examines the current challenges of AI-based radiomics in daily clinical oncology and offers possible solutions to these challenges. METHODS: Comprehensive electronic databases (PubMed, Medline via Ovid, Scopus, Web of Science, CINAHL, and Cochrane Library) were searched following the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. The quality of included studies and their risk of biases were evaluated using the Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD)and Prediction Model Risk of Bias Assessment Tool (PROBAST). RESULTS: Out of the 659 search hits retrieved, 45 fulfilled the inclusion criteria. Our review revealed that the application of AI-based radiomics model as an ancillary tool for improved decision-making in HNC management includes radiomics-based cancer diagnosis and radiomics-based cancer prognosis. The radiomics-based cancer diagnosis includes tumor staging, tumor grading, and classification of malignant and benign tumors. Similarly, radiomics-based cancer prognosis includes prediction for treatment response, recurrence, metastasis, and survival. In addition, the challenges in the implementation of these models for clinical evaluations include data imbalance, feature engineering (extraction and selection), model generalizability, multi-modal fusion, and model interpretability. CONCLUSION: Considering the highly subjective and interobserver variability that is peculiar to the interpretation of medical images by expert clinicians, AI-based radiomics seeks to offer potentially useful quantitative information, which is not visible to the human eye or unintentionally often remain ignored during clinical imaging practice. By enabling the extraction of this type of information, AI-based radiomics has the potential to revolutionize HNC oncology, providing a platform for more personalized, higher quality, and cost-effective care for HNC patients.

Interpretable machine learning model for prediction of overall survival in laryngeal cancer.

Background: The mortality rates of laryngeal squamous cell carcinoma cancer (LSCC) have not significantly decreased in the last decades.Objectives: We primarily aimed to compare the predictive performance of DeepTables with the state-of-the-art machine learning (ML) algorithms (Voting ensemble, Stack ensemble, and XGBoost) to stratify patients with LSCC into chance of overall survival (OS). In addition, we complemented the developed model by providing interpretability using both global and local model-agnostic techniques.Methods: A total of 2792 patients in the Surveillance, Epidemiology, and End Results (SEER) database diagnosed with LSCC were reviewed. The global model-agnostic interpretability was examined using SHapley Additive exPlanations (SHAP) technique. Likewise, individual interpretation of the prediction was made using Local Interpretable Model Agnostic Explanations (LIME).Results: The state-of-the-art ML ensemble algorithms outperformed DeepTables. Specifically, the examined ensemble algorithms showed comparable weighted area under receiving curve of 76.9, 76.8, and 76.1 with an accuracy of 71.2%, 70.2%, and 71.8%, respectively. The global methods of interpretability (SHAP) demonstrated that the age of the patient at diagnosis, N-stage, T-stage, tumor grade, and marital status are among the prominent parameters.Conclusions: A ML model for OS prediction may serve as an ancillary tool for treatment planning of LSCC patients.

Machine learning explainability in nasopharyngeal cancer survival using LIME and SHAP.

Nasopharyngeal cancer (NPC) has a unique histopathology compared with other head and neck cancers. Individual NPC patients may attain different outcomes. This study aims to build a prognostic system by combining a highly accurate machine learning model (ML) model with explainable artificial intelligence to stratify NPC patients into low and high chance of survival groups. Explainability is provided using Local Interpretable Model Agnostic Explanations (LIME) and SHapley Additive exPlanations (SHAP) techniques. A total of 1094 NPC patients were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database for model training and internal validation. We combined five different ML algorithms to form a uniquely stacked algorithm. The predictive performance of the stacked algorithm was compared with a state-of-the-art algorithm-extreme gradient boosting (XGBoost) to stratify the NPC patients into chance of survival groups. We validated our model with temporal validation (n = 547) and geographic external validation (Helsinki University Hospital NPC cohort, n = 60). The developed stacked predictive ML model showed an accuracy of 85.9% while the XGBoost had 84.5% after the training and testing phases. This demonstrated that both XGBoost and the stacked model showed comparable performance. External geographic validation of XGBoost model showed a c-index of 0.74, accuracy of 76.7%, and area under curve of 0.76. The SHAP technique revealed that age of the patient at diagnosis, T-stage, ethnicity, M-stage, marital status, and grade were among the prominent input variables in decreasing order of significance for the overall survival of NPC patients. LIME showed the degree of reliability of the prediction made by the model. In addition, both techniques showed how each feature contributed to the prediction made by the model. LIME and SHAP techniques provided personalized protective and risk factors for each NPC patient and unraveled some novel non-linear relationships between input features and survival chance. The examined ML approach showed the ability to predict the chance of overall survival of NPC patients. This is important for effective treatment planning care and informed clinical decisions. To enhance outcome results, including survival in NPC, ML may aid in planning individualized therapy for this patient population.

SCADA securing system using deep learning to prevent cyber infiltration.

Supervisory Control and Data Acquisition (SCADA) systems are computer-based control architectures specifically engineered for the operation of industrial machinery via hardware and software models. These systems are used to project, monitor, and automate the state of the operational network through the utilization of ethernet links, which enable two-way communications. However, as a result of their constant connectivity to the internet and the lack of security frameworks within their internal architecture, they are susceptible to cyber-attacks. In light of this, we have proposed an intrusion detection algorithm, intending to alleviate this security bottleneck. The proposed algorithm, the Genetically Seeded Flora (GSF) feature optimization algorithm, is integrated with Transformer Neural Network (TNN) and functions by detecting changes in operational patterns that may be indicative of an intruder's involvement. The proposed Genetically Seeded Flora Transformer Neural Network (GSFTNN) algorithm stands in stark contrast to the signature-based method employed by traditional intrusion detection systems. To evaluate the performance of the proposed algorithm, extensive experiments are conducted using the WUSTL-IIOT-2018 ICS SCADA cyber security dataset. The results of these experiments indicate that the proposed algorithm outperforms traditional algorithms such as Residual Neural Networks (ResNet), Recurrent Neural Networks (RNN), and Long Short-Term Memory (LSTM) in terms of accuracy and efficiency.

Application of artificial intelligence for overall survival risk stratification in oropharyngeal carcinoma: A validation of ProgTOOL.

BACKGROUND: In recent years, there has been a surge in machine learning-based models for diagnosis and prognostication of outcomes in oncology. However, there are concerns relating to the model's reproducibility and generalizability to a separate patient cohort (i.e., external validation). OBJECTIVES: This study primarily provides a validation study for a recently introduced and publicly available machine learning (ML) web-based prognostic tool (ProgTOOL) for overall survival risk stratification of oropharyngeal squamous cell carcinoma (OPSCC). Additionally, we reviewed the published studies that have utilized ML for outcome prognostication in OPSCC to examine how many of these models were externally validated, type of external validation, characteristics of the external dataset, and diagnostic performance characteristics on the internal validation (IV) and external validation (EV) datasets were extracted and compared. METHODS: We used a total of 163 OPSCC patients obtained from the Helsinki University Hospital to externally validate the ProgTOOL for generalizability. In addition, PubMed, OvidMedline, Scopus, and Web of Science databases were systematically searched according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. RESULTS: The ProgTOOL produced a predictive performance of 86.5% balanced accuracy, Mathew's correlation coefficient of 0.78, Net Benefit (0.7) and Brier score (0.06) for overall survival stratification of OPSCC patients as either low-chance or high-chance. In addition, out of a total of 31 studies found to have used ML for the prognostication of outcomes in OPSCC, only seven (22.6%) reported a form of EV. Three studies (42.9%) each used either temporal EV or geographical EV while only one study (14.2%) used expert as a form of EV. Most of the studies reported a reduction in performance when externally validated. CONCLUSION: The performance of the model in this validation study indicates that it may be generalized, therefore, bringing recommendations of the model for clinical evaluation closer to reality. However, the number of externally validated ML-based models for OPSCC is still relatively small. This significantly limits the transfer of these models for clinical evaluation and subsequently reduces the likelihood of the use of these models in daily clinical practice. As a gold standard, we recommend the use of geographical EV and validation studies to reveal biases and overfitting of these models. These recommendations are poised to facilitate the implementation of these models in clinical practice.

Advanced-stage tongue squamous cell carcinoma: a machine learning model for risk stratification and treatment planning.

BACKGROUND: A significant number of tongue squamous cell carcinoma (TSCC) patients are diagnosed at late stage. OBJECTIVES: We primarily aimed to develop a machine learning (ML) model based on ensemble ML paradigm to stratify advanced-stage TSCC patients into the likelihood of overall survival (OS) for evidence-based treatment. We compared the survival outcome of patients who received either surgical treatment only (Sx) or surgery combined with postoperative radiotherapy (Sx + RT) or postoperative chemoradiotherapy (Sx + CRT). MATERIAL AND METHODS: A total of 428 patients from Surveillance, Epidemiology, and End Results (SEER) database were reviewed. Kaplan-Meier and Cox proportional hazards models examine OS. In addition, a ML model was developed for OS likelihood stratification. RESULTS: Age, marital status, N stage, Sx, and Sx + CRT were considered significant. Patients with Sx + RT showed better OS than Sx + CRT or Sx alone. A similar result was obtained for T3N0 subgroup. For T3N1 subgroup, Sx + CRT appeared more favorable for 5-year OS. In T3N2 and T3N3 subgroups, the numbers of patients were small to make insightful conclusions. The OS predictive ML model showed an accuracy of 86.3% for OS likelihood prediction. CONCLUSIONS AND SIGNIFICANCE: Patients stratified as having high likelihood of OS may be managed with Sx + RT. Further external validation studies are needed to confirm these results.

Proposed algorithm for smart grid DDoS detection based on deep learning.

The Smart Grid's objective is to increase the electric grid's dependability, security, and efficiency through extensive digital information and control technology deployment. As a result, it is necessary to apply real-time analysis and state estimation-based techniques to ensure efficient controls are implemented correctly. These systems are vulnerable to cyber-attacks, posing significant risks to the Smart Grid's overall availability due to their reliance on communication technology. Therefore, effective intrusion detection algorithms are required to mitigate such attacks. In dealing with these uncertainties, we propose a hybrid deep learning algorithm that focuses on Distributed Denial of Service attacks on the communication infrastructure of the Smart Grid. The proposed algorithm is hybridized by the Convolutional Neural Network and the Gated Recurrent Unit algorithms. Simulations are done using a benchmark cyber security dataset of the Canadian Institute of Cybersecurity Intrusion Detection System. According to the simulation results, the proposed algorithm outperforms the current intrusion detection algorithms, with an overall accuracy rate of 99.7%.

An interpretable machine learning prognostic system for risk stratification in oropharyngeal cancer.

BACKGROUND: The optimal management of oropharyngeal squamous cell carcinoma (OPSCC) includes both surgical and non-surgical, that is, (chemo)radiotherapy treatment options and their combinations. These approaches carry a risk of specific treatment-related side effects. HPV-positive OPSCC has been reported to be more sensitive to (chemo)radiotherapy-based treatment modalities. OBJECTIVES: This study aims to demonstrate how machine learning can aid in classifying OPSCC patients into risk groups (low-chance or high-chance) for overall survival. We examined the input variables using permutation feature importance. Furthermore, we provided explanations and interpretations using the Local Interpretable Model Agnostic Explanations (LIME) and SHapley Additive Explanation (SHAP) frameworks. METHODS: The machine learning model for 3164 OPSCC patients was built using data obtained from the Surveillance, Epidemiology, and End Results (SEER) program database. A total of five variants of tree-based machine learning algorithms (voting ensemble, light GBM, XGBoost, Random Forest, and Extreme Random Trees) were used to divide the patients into risk groups. The developed model with the best predictive performance was temporally validated with a different cohort. RESULTS: The voting ensemble machine learning algorithm showed an accuracy of 88.3%, Mathews' correlation coefficient of 0.72, and weighted area under curve of 0.93, when temporally validated. Human papillomavirus (HPV) status, age of the patients, T stage, marital status, N stage, and the treatment modality (surgery with postoperative radiotherapy) were found to have the most significant effects on the ability of the machine learning model to predict overall survival. Similarly, for the individual patients with SHAP framework, HPV status, gender, and treatment modality (surgery with postoperative radiotherapy) were the input features that improved the model's prediction. CONCLUSION: The proposed stratification of OPSCC patients into risk groups by machine learning techniques can provide accurate predictions and thus aid clinicians in administering early and personalized interventions. Clinicians could utilize the predicted risk with the explanations offered by the SHAP and LIME frameworks to understand previously undetected relationships between prognostic variables to make informed clinical decisions and effective interventions.

Measuring the Usability and Quality of Explanations of a Machine Learning Web-Based Tool for Oral Tongue Cancer Prognostication.

Background: Machine learning models have been reported to assist in the proper management of cancer through accurate prognostication. Integrating such models as a web-based prognostic tool or calculator may help to improve cancer care and assist clinicians in making oral cancer management-related decisions. However, none of these models have been recommended in daily practices of oral cancer due to concerns related to machine learning methodologies and clinical implementation challenges. An instance of the concerns inherent to the science of machine learning is explainability. Objectives: This study measures the usability and explainability of a machine learning-based web prognostic tool that was designed for prediction of oral tongue cancer. We used the System Usability Scale (SUS) and System Causability Scale (SCS) to evaluate the explainability of the prognostic tool. In addition, we propose a framework for the evaluation of post hoc explainability of web-based prognostic tools. Methods: A SUS- and SCS-based questionnaire was administered amongst pathologists, radiologists, cancer and machine learning researchers and surgeons (n = 11) to evaluate the quality of explanations offered by the machine learning-based web prognostic tool to address the concern of explainability and usability of these models for cancer management. The examined web-based tool was developed by our group and is freely available online. Results: In terms of the usability of the web-based tool using the SUS, 81.9% (45.5% strongly agreed; 36.4% agreed) agreed that neither the support of a technical assistant nor a need to learn many things were required to use the web-based tool. Furthermore, 81.8% agreed that the evaluated web-based tool was not cumbersome to use (usability). The average score for the SCS (explainability) was 0.74. A total of 91.0% of the participants strongly agreed that the web-based tool can assist in clinical decision-making. These scores indicated that the examined web-based tool offers a significant level of usability and explanations about the outcome of interest. Conclusions: Integrating the trained and internally and externally validated model as a web-based tool or calculator is poised to offer an effective and easy approach towards the usage and acceptance of these models in the future daily practice. This approach has received significant attention in recent years. Thus, it is important that the usability and explainability of these models are measured to achieve such touted benefits. A usable and well-explained web-based tool further brings the use of these web-based tools closer to everyday clinical practices. Thus, the concept of more personalized and precision oncology can be achieved.

Mitigating Burnout in an Oncological Unit: A Scoping Review.

Objectives: The purpose of this study was to provide a scoping review on how to address and mitigate burnout in the profession of clinical oncology. Also, it examines how artificial intelligence (AI) can mitigate burnout in oncology. Methods: We searched Ovid Medline, PubMed, Scopus, and Web of Science, for articles that examine how to address burnout in oncology. Results: A total of 17 studies were found to examine how burnout in oncology can be mitigated. These interventions were either targeted at individuals (oncologists) or organizations where the oncologists work. The organizational interventions include educational (psychosocial and mindfulness-based course), art therapies and entertainment, team-based training, group meetings, motivational package and reward, effective leadership and policy change, and staff support. The individual interventions include equipping the oncologists with adequate training that include-communication skills, well-being and stress management, burnout education, financial independence, relaxation, self-efficacy, resilience, hobby adoption, and work-life balance for the oncologists. Similarly, AI is thought to be poised to offer the potential to mitigate burnout in oncology by enhancing the productivity and performance of the oncologists, reduce the workload and provide job satisfaction, and foster teamwork between the caregivers of patients with cancer. Discussion: Burnout is common among oncologists and can be elicited from different types of situations encountered in the process of caring for patients with cancer. Therefore, for these interventions to achieve the touted benefits, combinatorial strategies that combine other interventions may be viable for mitigating burnout in oncology. With the potential of AI to mitigate burnout, it is important for healthcare providers to facilitate its use in daily clinical practices. Conclusion: These combinatorial interventions can ensure job satisfaction, a supportive working environment, job retention for oncologists, and improved patient care. These interventions could be integrated systematically into routine cancer care for a positive impact on quality care, patient satisfaction, the overall success of the oncological ward, and the health organizations at large.

Machine learning in oral squamous cell carcinoma: Current status, clinical concerns and prospects for future-A systematic review.

BACKGROUND: Oral cancer can show heterogenous patterns of behavior. For proper and effective management of oral cancer, early diagnosis and accurate prediction of prognosis are important. To achieve this, artificial intelligence (AI) or its subfield, machine learning, has been touted for its potential to revolutionize cancer management through improved diagnostic precision and prediction of outcomes. Yet, to date, it has made only few contributions to actual medical practice or patient care. OBJECTIVES: This study provides a systematic review of diagnostic and prognostic application of machine learning in oral squamous cell carcinoma (OSCC) and also highlights some of the limitations and concerns of clinicians towards the implementation of machine learning-based models for daily clinical practice. DATA SOURCES: We searched OvidMedline, PubMed, Scopus, Web of Science, and Institute of Electrical and Electronics Engineers (IEEE) databases from inception until February 2020 for articles that used machine learning for diagnostic or prognostic purposes of OSCC. ELIGIBILITY CRITERIA: Only original studies that examined the application of machine learning models for prognostic and/or diagnostic purposes were considered. DATA EXTRACTION: Independent extraction of articles was done by two researchers (A.R. & O.Y) using predefine study selection criteria. We used the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) in the searching and screening processes. We also used Prediction model Risk of Bias Assessment Tool (PROBAST) for assessing the risk of bias (ROB) and quality of included studies. RESULTS: A total of 41 studies were published to have used machine learning to aid in the diagnosis/or prognosis of OSCC. The majority of these studies used the support vector machine (SVM) and artificial neural network (ANN) algorithms as machine learning techniques. Their specificity ranged from 0.57 to 1.00, sensitivity from 0.70 to 1.00, and accuracy from 63.4 % to 100.0 % in these studies. The main limitations and concerns can be grouped as either the challenges inherent to the science of machine learning or relating to the clinical implementations. CONCLUSION: Machine learning models have been reported to show promising performances for diagnostic and prognostic analyses in studies of oral cancer. These models should be developed to further enhance explainability, interpretability, and externally validated for generalizability in order to be safely integrated into daily clinical practices. Also, regulatory frameworks for the adoption of these models in clinical practices are necessary.

Utilizing Deep Machine Learning for Prognostication of Oral Squamous Cell Carcinoma-A Systematic Review.

The application of deep machine learning, a subfield of artificial intelligence, has become a growing area of interest in predictive medicine in recent years. The deep machine learning approach has been used to analyze imaging and radiomics and to develop models that have the potential to assist the clinicians to make an informed and guided decision that can assist to improve patient outcomes. Improved prognostication of oral squamous cell carcinoma (OSCC) will greatly benefit the clinical management of oral cancer patients. This review examines the recent development in the field of deep learning for OSCC prognostication. The search was carried out using five different databases-PubMed, Scopus, OvidMedline, Web of Science, and Institute of Electrical and Electronic Engineers (IEEE). The search was carried time from inception until 15 May 2021. There were 34 studies that have used deep machine learning for the prognostication of OSCC. The majority of these studies used a convolutional neural network (CNN). This review showed that a range of novel imaging modalities such as computed tomography (or enhanced computed tomography) images and spectra data have shown significant applicability to improve OSCC outcomes. The average specificity, sensitivity, area under receiving operating characteristics curve [AUC]), and accuracy for studies that used spectra data were 0.97, 0.99, 0.96, and 96.6%, respectively. Conversely, the corresponding average values for these parameters for computed tomography images were 0.84, 0.81, 0.967, and 81.8%, respectively. Ethical concerns such as privacy and confidentiality, data and model bias, peer disagreement, responsibility gap, patient-clinician relationship, and patient autonomy have limited the widespread adoption of these models in daily clinical practices. The accumulated evidence indicates that deep machine learning models have great potential in the prognostication of OSCC. This approach offers a more generic model that requires less data engineering with improved accuracy.

Deep Machine Learning for Oral Cancer: From Precise Diagnosis to Precision Medicine.

Oral squamous cell carcinoma (OSCC) is one of the most prevalent cancers worldwide and its incidence is on the rise in many populations. The high incidence rate, late diagnosis, and improper treatment planning still form a significant concern. Diagnosis at an early-stage is important for better prognosis, treatment, and survival. Despite the recent improvement in the understanding of the molecular mechanisms, late diagnosis and approach toward precision medicine for OSCC patients remain a challenge. To enhance precision medicine, deep machine learning technique has been touted to enhance early detection, and consequently to reduce cancer-specific mortality and morbidity. This technique has been reported to have made a significant progress in data extraction and analysis of vital information in medical imaging in recent years. Therefore, it has the potential to assist in the early-stage detection of oral squamous cell carcinoma. Furthermore, automated image analysis can assist pathologists and clinicians to make an informed decision regarding cancer patients. This article discusses the technical knowledge and algorithms of deep learning for OSCC. It examines the application of deep learning technology in cancer detection, image classification, segmentation and synthesis, and treatment planning. Finally, we discuss how this technique can assist in precision medicine and the future perspective of deep learning technology in oral squamous cell carcinoma.

Comparison of nomogram with machine learning techniques for prediction of overall survival in patients with tongue cancer.

BACKGROUND: The prediction of overall survival in tongue cancer is important for planning of personalized care and patient counselling. OBJECTIVES: This study compares the performance of a nomogram with a machine learning model to predict overall survival in tongue cancer. The nomogram and machine learning model were built using a large data set from the Surveillance, Epidemiology, and End Results (SEER) program database. The comparison is necessary to provide the clinicians with a comprehensive, practical, and most accurate assistive system to predict overall survival of this patient population. METHODS: The data set used included the records of 7596 tongue cancer patients. The considered machine learning algorithms were logistic regression, support vector machine, Bayes point machine, boosted decision tree, decision forest, and decision jungle. These algorithms were mainly evaluated in terms of the areas under the receiver-operating characteristic (ROC) curve (AUC) and accuracy values. The performance of the algorithm that produced the best result was compared with a nomogram to predict overall survival in tongue cancer patients. RESULTS: The boosted decision-tree algorithm outperformed other algorithms. When compared with a nomogram using external validation data, the boosted decision tree produced an accuracy of 88.7% while the nomogram showed an accuracy of 60.4%. In addition, it was found that age of patient, T stage, radiotherapy, and the surgical resection were the most prominent features with significant influence on the machine learning model's performance to predict overall survival. CONCLUSION: The machine learning model provides more personalized and reliable prognostic information of tongue cancer than the nomogram. However, the level of transparency offered by the nomogram in estimating patients' outcomes seems more confident and strengthened the principle of shared decision making between the patient and clinician. Therefore, a combination of a nomogram - machine learning (NomoML) predictive model may help to improve care, provides information to patients, and facilitates the clinicians in making tongue cancer management-related decisions.

Comparison of supervised machine learning classification techniques in prediction of locoregional recurrences in early oral tongue cancer.

BACKGROUND: The proper estimate of the risk of recurrences in early-stage oral tongue squamous cell carcinoma (OTSCC) is mandatory for individual treatment-decision making. However, this remains a challenge even for experienced multidisciplinary centers. OBJECTIVES: We compared the performance of four machine learning (ML) algorithms for predicting the risk of locoregional recurrences in patients with OTSCC. These algorithms were Support Vector Machine (SVM), Naive Bayes (NB), Boosted Decision Tree (BDT), and Decision Forest (DF). MATERIALS AND METHODS: The study cohort comprised 311 cases from the five University Hospitals in Finland and A.C. Camargo Cancer Center, São Paulo, Brazil. For comparison of the algorithms, we used the harmonic mean of precision and recall called F1 score, specificity, and accuracy values. These algorithms and their corresponding permutation feature importance (PFI) with the input parameters were externally tested on 59 new cases. Furthermore, we compared the performance of the algorithm that showed the highest prediction accuracy with the prognostic significance of depth of invasion (DOI). RESULTS: The results showed that the average specificity of all the algorithms was 71% . The SVM showed an accuracy of 68% and F1 score of 0.63, NB an accuracy of 70% and F1 score of 0.64, BDT an accuracy of 81% and F1 score of 0.78, and DF an accuracy of 78% and F1 score of 0.70. Additionally, these algorithms outperformed the DOI-based approach, which gave an accuracy of 63%. With PFI-analysis, there was no significant difference in the overall accuracies of three of the algorithms; PFI-BDT accuracy increased to 83.1%, PFI-DF increased to 80%, PFI-SVM decreased to 64.4%, while PFI-NB accuracy increased significantly to 81.4%. CONCLUSIONS: Our findings show that the best classification accuracy was achieved with the boosted decision tree algorithm. Additionally, these algorithms outperformed the DOI-based approach. Furthermore, with few parameters identified in the PFI analysis, ML technique still showed the ability to predict locoregional recurrence. The application of boosted decision tree machine learning algorithm can stratify OTSCC patients and thus aid in their individual treatment planning.

Cancer Modeling-on-a-Chip with Future Artificial Intelligence Integration.

Cancer is one of the leading causes of death worldwide, despite the large efforts to improve the understanding of cancer biology and development of treatments. The attempts to improve cancer treatment are limited by the complexity of the local milieu in which cancer cells exist. The tumor microenvironment (TME) consists of a diverse population of tumor cells and stromal cells with immune constituents, microvasculature, extracellular matrix components, and gradients of oxygen, nutrients, and growth factors. The TME is not recapitulated in traditional models used in cancer investigation, limiting the translation of preliminary findings to clinical practice. Advances in 3D cell culture, tissue engineering, and microfluidics have led to the development of "cancer-on-a-chip" platforms that expand the ability to model the TME in vitro and allow for high-throughput analysis. The advances in the development of cancer-on-a-chip platforms, implications for drug development, challenges to leveraging this technology for improved cancer treatment, and future integration with artificial intelligence for improved predictive drug screening models are discussed.

Machine learning application for prediction of locoregional recurrences in early oral tongue cancer: a Web-based prognostic tool.

Estimation of risk of recurrence in early-stage oral tongue squamous cell carcinoma (OTSCC) remains a challenge in the field of head and neck oncology. We examined the use of artificial neural networks (ANNs) to predict recurrences in early-stage OTSCC. A Web-based tool available for public use was also developed. A feedforward neural network was trained for prediction of locoregional recurrences in early OTSCC. The trained network was used to evaluate several prognostic parameters (age, gender, T stage, WHO histologic grade, depth of invasion, tumor budding, worst pattern of invasion, perineural invasion, and lymphocytic host response). Our neural network model identified tumor budding and depth of invasion as the most important prognosticators to predict locoregional recurrence. The accuracy of the neural network was 92.7%, which was higher than that of the logistic regression model (86.5%). Our online tool provided 88.2% accuracy, 71.2% sensitivity, and 98.9% specificity. In conclusion, ANN seems to offer a unique decision-making support predicting recurrences and thus adding value for the management of early OTSCC. To the best of our knowledge, this is the first study that applied ANN for prediction of recurrence in early OTSCC and provided a Web-based tool.