1.
J Med Chem
; 24(3): 295-9, 1981 Mar.
Article
in English
| MEDLINE
| ID: mdl-6790703
ABSTRACT
A variety of naphthoquinones have veen prepared and evaluated in vitro against the causative agent of the cattle disease East Coast Fever-Theileria parva infection. It is concluded from structure-activity studies that a 2-hydroxyl moiety es essential for high activity. The most active compounds tested were 2-hydroxy-3-alkyl-1,4-naphthoquinones in which the alkyl moiety was cyclohexyl, cyclohexylcyclohexyl, tridecyl, or tetradecyl.
Subject(s)
Antiprotozoal Agents/pharmacology , Apicomplexa/drug effects , Naphthoquinones/pharmacology , Theileriasis/parasitology , Animals , Antiprotozoal Agents/chemical synthesis , Cattle , Naphthoquinones/chemical synthesis , Structure-Activity Relationship
2.
Trans R Soc Trop Med Hyg
; 74(5): 670-1, 1980.
Article
in English
| MEDLINE
| ID: mdl-6782719
3.
Int J Parasitol
; 8(1): 25-31, 1978 Feb.
Article
in English
| MEDLINE
| ID: mdl-415993