1.
Proteins
; 56(2): 387-91, 2004 Aug 01.
Article
in English
| MEDLINE
| ID: mdl-15211522
Subject(s)
Bacterial Proteins/chemistry , Cysteine Synthase/chemistry , Thermotoga maritima/enzymology , Amino Acid Sequence , Bacterial Proteins/metabolism , Binding Sites , Crystallography, X-Ray , Cysteine Synthase/metabolism , Ligands , Models, Molecular , Molecular Sequence Data , Phosphates/metabolism , Protein Conformation , Protein Structure, Secondary , Protein Structure, Tertiary
2.
Proteins
; 54(1): 174-7, 2004 Jan 01.
Article
in English
| MEDLINE
| ID: mdl-14705036
3.
Proteins
; 53(1): 142-5, 2003 Oct 01.
Article
in English
| MEDLINE
| ID: mdl-12945057
4.
Nat Immunol
; 4(8): 808-15, 2003 Aug.
Article
in English
| MEDLINE
| ID: mdl-12833155
ABSTRACT
CD1 antigens bind a variety of self and foreign lipid and glycolipid antigens for presentation to CD1-restricted T cell receptors (TCRs). Here we report the crystal structure of human CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A. The lipid adopts an S-shaped conformation, with the sphingosine chain completely buried in the A' pocket and the fatty acid chain emerging from the interface of the A' pocket into the more exposed F' pocket. The headgroup is anchored in the A'-F' junction and protrudes into the F' pocket for TCR recognition. Because the A' pocket is narrow with a fixed terminus, it can act as a molecular 'ruler' to select alkyl chains of a particular length.
Subject(s)
Antigens, CD1/chemistry , Autoantigens/chemistry , Sulfoglycosphingolipids/chemistry , Antigens, CD1/metabolism , Autoantigens/metabolism , Binding Sites , Crystallography , Humans , Sulfoglycosphingolipids/metabolism
5.
Proteins
; 50(2): 371-4, 2003 Feb 01.
Article
in English
| MEDLINE
| ID: mdl-12486729
6.
Proteins
; 49(1): 142-5, 2002 Oct 01.
Article
in English
| MEDLINE
| ID: mdl-12211025