ABSTRACT
Two glycopeptide antibiotics MM 47761 and MM 47921 have been isolated from Amycolatopsis orientalis NCIB 12608. Fermentation conditions for their production, and methods for their isolation are described. The metabolites have been characterised by physio-chemical and biological properties and the structure determined by a combination of chemical degradation, COSY and NOE NMR studies. Both metabolites showed good antibacterial activity against Gram-positive organisms.
Subject(s)
Actinomycetales/metabolism , Aminoglycosides , Anti-Bacterial Agents/biosynthesis , Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/isolation & purification , Anti-Bacterial Agents/pharmacology , Chromatography, High Pressure Liquid , Chromatography, Ion Exchange , Fermentation , Gram-Positive Bacteria/drug effects , Immunodiffusion , Magnetic Resonance Spectroscopy , Mass Spectrometry , Molecular Structure , Spectrophotometry, UltravioletABSTRACT
A number of new granaticin type quinone antibiotics have been isolated from Streptomyces lateritus ATCC 19913. Spectroscopic evidence is presented which has led to the structure elucidation of three new antibiotics and the chemical relationship between members of the granaticin series has been studied.
