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1.
Ter Arkh ; 90(2): 35-42, 2018 Feb 15.
Article in English | MEDLINE | ID: mdl-30701770

ABSTRACT

AIM: European Registry on the management of Helicobacter pylori infection («Hp-EuReg¼) - a multicenter prospective observational study initiated by the European Helicobacter and Microbiota Study Group, conducted in 27 European countries in order to evaluate the real clinical practice of diagnosis and treatment of H. pylori and its comparison with international recommendations. MATERIALS AND METHODS: The analysis of 2360 patients entered in the register by the Russian centres of «Hp-EuReg¼ in 2013-2017, who were underwent 1st line eradication therapy. RESULTS: The most common methods of primary diagnosis of H. pylori are histological (37.7%), rapid urease test (29.2%) and serology (29.7%). The duration of eradication therapy in 9.4% of cases was 7 days, in 65.3% - 10 days, and in 25.3% - 14 days. To control the effec- tiveness of treatment, H. pylori antigen in feces (31.3%), urea breath test (23.4%) and histological method (23.3%) were used. In 3.6% cases was used serology by mistake. In 17.3% of patients control was not carried out. The effectiveness of triple therapy with a PPI, amoxicillin, clar- ithromycin (per protocol) was 67.6%, with 7-day course, 81.1% at 10-day and 86.7% at 14-day course. Eradication rate of triple therapy with addition of bismuth (per protocol) reached 90,6% in the group receiving 10-day scheme and 93.6% in the group receiving the 14-day treatment. CONCLUSION: Significant deviations of clinical practice from expert recommendations, most pronounced at the stage of monitoring the effectiveness of therapy, were noted. The suboptimal efficacy of triple therapy is shown.


Subject(s)
Anti-Bacterial Agents , Helicobacter Infections , Proton Pump Inhibitors , Amoxicillin/therapeutic use , Anti-Bacterial Agents/therapeutic use , Clarithromycin , Drug Therapy, Combination , Europe , Helicobacter Infections/drug therapy , Helicobacter pylori , Humans , Prospective Studies , Proton Pump Inhibitors/therapeutic use , Registries
2.
Ter Arkh ; 90(12): 133-139, 2018 Dec 30.
Article in English | MEDLINE | ID: mdl-30701845

ABSTRACT

Diagnostic tests used to detection Helicobacter pylori are divided into invasive (requiring endoscopy) and non-invasive, direct (bacteriological, histological or molecular detection of the bacterium) and indirect (detection of urease activity of the bacterium or antibodies to it). The choice of the test is determined by the clinical situation, as well as by its availability and cost. The sensitivity of most tests is affected by the use of antisecretory drugs and antibiotics.


Subject(s)
Helicobacter Infections , Helicobacter pylori , Breath Tests , Helicobacter Infections/diagnosis , Helicobacter pylori/isolation & purification , Humans , Sensitivity and Specificity , Urea , Urease
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