1.
S Afr Med J
; 106(6 Suppl 1): S65-6, 2016 May 25.
Article
in English
| MEDLINE
| ID: mdl-27245530
ABSTRACT
In certain autosomal recessive disorders there is suggestive evidence that heterozygous carriers may have some selective advantage over normal homozygotes. These include, for example, cystic fibrosis, Tay-Sachs disease and phenylketonuria. The best example so far, however, is that of significant heterozygous advantage in sickle-cell anaemia with increased resistance to falciparum malaria.