Subject(s)
Bile Acids and Salts/blood , Diarrhea, Infantile/blood , Alanine Transaminase/blood , Aspartate Aminotransferases/blood , Cholestyramine Resin/therapeutic use , Diarrhea, Infantile/enzymology , Diarrhea, Infantile/therapy , Female , Humans , Infant , Infant, Newborn , Liver Diseases/etiology , Male , Nutrition Disorders/etiology , Parenteral NutritionABSTRACT
Se estudio el nivel serico de acidos biliares totales e individuales y transaminasas glutamicooxalacetica y glutamicopiruvica en 47 lactantes hospitalizados por sindrome diarreico, distinguiendo controles, diarrea aguda, prolongada y refractaria. En estos ultimos, se investigo ademas el efecto de la terapeutica con colestiramina y nutricion parenteral total. Los ninos con diarrea, sin importar forma evolutiva, tienen un nivel significativamente mas bajo de acidos biliares sericos que los controles, situacion que se acentua en aquellos que reciben colestiramina y nutricion parenteral total. La transaminasa glutamicooxalacetica se encuentra significativamente elevada en los ninos con diarrea refractaria. Se sugiere que esto puede ser la primera etapa en el desarrollo de dano hepatico en esta condicion patologica
Subject(s)
Infant , Humans , Male , Female , Bile Acids and Salts , Diarrhea, InfantileABSTRACT
Se estudia la excrecion fecal en 24 horas de AB totales e individuales en 47 lactantes hospitalizados por sindrome diarreico distinguiendo controles, diarreia aguda, prolongada y refractaria. En estos ultimos se investiga ademas el efecto de la terapeutica con colestiramina y nutricion parenteral total. Los ninos con diarrea excretan AB exclusivamente desconjugados. La excrecion es significativamente mayor en los ninos con diarrea refractaria. No hay diferencias cualitativas en la estructura de AB excretados en las diversas formas evolutivas de diarrea. En los ninos tratados con colestiramina no se detectan AB en la fase liquida de las heces y en aquellos que reciben nutricion parenteral total, el nivel de excrecion es aproximadamente l/5 del encontrado en el grupo control
Subject(s)
Infant , Humans , Male , Female , Bile Acids and Salts , Cholestyramine Resin , Diarrhea, Infantile , Parenteral NutritionABSTRACT
Ninety-six infants were studied with water balance technique at the Infant Unit of Hospital Roberto del Río, Santiago de Chile. Sixty-eight with acute diarrhoea and twenty-eight with protracted diarrhoea associated to carbohydrate intolerance. Total water losses in most of them were in the range of 150 to 225 ml/kg day. Stool loses were in the range of 25 to 75 gm/kg/day, with humidity percentage varing from 97.4 to 92.5%. In patients with acute diarrhoea, stool losses and humidity percentage showed slight decreasing tendency in the following balances. By contrast, those with protracted diarrhoea showed a definite decreasing tendency in both parameters. Most infants showed a urinary output in the range of 20 to 80 ml/kg/day. Ten percent showed oliguria. Polyuria was observed occasionally. Insensible water losses were in the range of 50 to 80 ml/kg/day. Most patients showed weight gain of 0.1 to 5.0% in the first balance. Stool acidity and presence of reductant substances (tested by positivity of Fehling reaction) were found in 24% of infants with acute diarrhoea in the first balance. Sodium concentration in stools varied from 40 to 70 mEq/l; and potassium varied between 20 and 40 mEq/l. Bacterial pathogens were isolated in 64% of patients with acute diarrhoea; most of them E. coli enteropathogenic.
Subject(s)
Diarrhea, Infantile/metabolism , Dehydration/diet therapy , Dehydration/metabolism , Diarrhea, Infantile/diet therapy , Fluid Therapy , Humans , Infant, Newborn , Water/metabolism , Water-Electrolyte BalanceABSTRACT
32 infants admitted to Hospital "Roberto del Río" with infectious diarrhea and dehydration were assigned random to two groups, one of them receiving the usual therapeutic regimen of rehydration, refeeding and furazolidone and the other group the same treatment plus cholestyramine. The patients were studied with balance technique on days 1st, 3rd., and 5th. after admission, analyzing clinical progress, features of the stools, total digestive transit time, pH of the feces and the presence of reducing substances, volume of the stools, water excretion and sodium, potassium and chloride elimination in the feces. The patients receiving cholestyramine showed an earlier improvement in the appearance of the stools, less excretion of feces and water and diminished sodium and potassium elimination. Chloride excretion was similar in both groups. Cholestyramine tolerance was excellent. No side effects or complications were observed.
