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1.
J Neuroendovasc Ther ; 15(10): 653-658, 2021.
Article in English | MEDLINE | ID: mdl-37502372

ABSTRACT

Objective: We report a patient with chronic headache due to idiopathic intracranial hypertension (IIH) associated with transverse sinus (TS) stenosis. The symptom improved after stent placement at the site of stenosis. Case Presentation: The patient was a 37-year-old woman with progressive headache and diplopia as chief complaints. She had severe bilateral papilledema. Magnetic resonance imaging (MRI) and angiography revealed stenosis of the bilateral TS. Lumbar puncture demonstrated raised intracranial pressure and IIH was tentatively diagnosed. Visual impairment progressed despite oral acetazolamide therapy. A venous pressure gradient was monitored during stent placement. The pressure gradient improved after stenting. Dual antiplatelet therapy was initiated 1 week before the procedure. Papilledema and headache resolved immediately after the procedure. No in-stent stenosis or occlusion occurred during the follow-up period. Conclusion: Stent placement for TS stenosis can improve the cerebral venous return in IIH patients. Although restenosis is possible, venous sinus stenting is considered an effective treatment.

2.
Mult Scler Relat Disord ; 38: 101444, 2020 Feb.
Article in English | MEDLINE | ID: mdl-31711001

ABSTRACT

A 25-year-old male presented with blurred peripheral vision and movement pain in his right eye. Fundus examination revealed unilateral disc swelling in his right eye with normal intracranial pressure. MRI showed remarkably high intensity in the optic nerve sheath and slightly high intensity in the optic nerve, indicating optic perineuritis (OPN). Anti-myelin oligodendrocyte glycoprotein (MOG) antibody was positive in both serum and cerebrospinal fluid. The patient responded promptly to corticosteroid treatment. OPN can be associated with the presence of anti-MOG antibody.


Subject(s)
Adrenal Cortex Hormones/pharmacology , Autoantibodies/metabolism , Myelin-Oligodendrocyte Glycoprotein/immunology , Optic Neuritis/diagnosis , Vision Disorders , Adrenal Cortex Hormones/administration & dosage , Adult , Autoantibodies/blood , Autoantibodies/cerebrospinal fluid , Humans , Magnetic Resonance Imaging , Male , Optic Neuritis/complications , Optic Neuritis/drug therapy , Optic Neuritis/immunology , Papilledema/diagnostic imaging , Papilledema/drug therapy , Papilledema/etiology , Prednisolone/pharmacology , Vision Disorders/etiology
4.
Article in English | MEDLINE | ID: mdl-21753898

ABSTRACT

BACKGROUND: To determine whether psychotropic cessation in patients with drug-induced blepharospasm improves motor symptoms. METHODS: In patients with drug-induced blepharospasm, we withdrew part or all of their psychotropic medication and assessed motor symptoms using the Jankovic rating scale (0 = none, 1 = noticeable, 2 = mild, 3 = moderate, 4 = severe) at first presentation and after cessation. RESULTS: Twelve patients (eleven women and one man, mean age 60.4 years) were enrolled. Psychotropics were administered before the onset of blepharospasm in all patients. The mean duration of treatment with psychotropic medication was 47.3 (range 3-120) months. Jankovic rating scale at initial presentation was 3 in eleven patients and 2 in one patient. After cessation, blepharospasm started to improve in all cases within 2 months (average 3.9 weeks). While the effect of psychotropic cessation was variable, the symptoms eventually improved to more than 2 on the rating scale. Three of the twelve patients underwent a single botulinum neurotoxin injection and were withdrawn from therapy after cessation. CONCLUSION: Psychotropic drugs can cause blepharospasm in some cases. Clinicians should consider reducing psychotropic medication as far as possible in patients with blepharospasm taking these agents.

5.
Retin Cases Brief Rep ; 4(4): 312-6, 2010.
Article in English | MEDLINE | ID: mdl-25390906

ABSTRACT

PURPOSE: To report regression of choroidal neovascularization following vitrectomy for endophthalmitis after antivascular endothelial growth factor injections. METHODS: Observational case series of two patients with exudative age-related macular degeneration. RESULTS: Endophthalmitis developed 2 days after the fourth ranibizumab injection in 1 case and 1 day after the ninth bevacizumab injection in another case. Vitrectomy and intravitreal antibiotic injections were performed. There was no bacterial growth on the cultures. Postoperative fluorescein angiography and combined optical coherence tomography/scanning laser ophthalmoscopy showed regression of choroidal neovascularization that was sustained after 29 and 32 months follow-up. CONCLUSION: In both patients with active exudative age-related macular degeneration, regression of choroidal new vessels occurred after vitrectomy and injection of intravitreal antibiotics for the treatment of endophthalmitis. Removal of the posterior vitreous during vitrectomy may have eliminated the contribution of vitreous to exudative age-related macular degeneration and choroidal neovascularization.

6.
Mov Disord ; 25(4): 433-9, 2010 Mar 15.
Article in English | MEDLINE | ID: mdl-20014062

ABSTRACT

To localize regional alterations in cerebral glucose metabolism in essential blepharospasm (EB) patients with photophobia. We have studied 22 EB patients by performing positron emission tomography and [(18)F]-fluorodeoxyglucose analysis. The patients were classified into two subgroups, namely, EB with photophobia (P group) and EB without photophobia (NP group), and compared with a healthy control group (n = 44). There were no significant differences between the two patient groups with respect to the severity of motor symptoms or the duration for which the condition persisted. The FDG-PET images were analyzed using the statistical parametric mapping software. As compared to the control group, the P group exhibited significant hypermetabolism in the thalamus (P = 0.002), while the NP group exhibited significant hypometabolism in the dorsal midbrain, especially, in the superior colliculus (P = 0.005). The P group exhibited significant hypermetabolism in the thalamus and the dorsal midbrain as compared to the NP group (P < 0.001). These findings suggest that photophobia in EB patients may be associated with abnormal hyperactivity in the thalamus. Either hyperactivity of the thalamus or hypoactivity of the superior colliculus, or both may be associated with excessive blinking in these patients.


Subject(s)
Blepharospasm/psychology , Photophobia/etiology , Positron-Emission Tomography , Adult , Female , Fluorodeoxyglucose F18 , Humans , Male , Middle Aged , Nerve Net/physiopathology , Neural Pathways/physiopathology , Occipital Lobe/physiopathology , Photophobia/diagnosis , Photophobia/physiopathology , Radiopharmaceuticals , Thalamus/physiopathology , Trigeminal Nerve/physiopathology
7.
J Pediatr Ophthalmol Strabismus ; 46(6): 358-61, 2009.
Article in English | MEDLINE | ID: mdl-19928741

ABSTRACT

PURPOSE: Variable eye misalignment and blepharoptosis in childhood ocular myasthenia gravis can lead to permanent binocular visual loss. However, a standard ophthalmologic intervention for this condition has yet to be fully established. This study investigated the influence of variable eye misalignment and asymmetric blepharoptosis on the development of binocular vision in childhood ocular myasthenia gravis. METHODS: The authors retrospectively reviewed clinical records of consecutive patients with childhood ocular myasthenia gravis whose age of onset was younger than 36 months and who had follow-up periods of more than 1 year. Five patients were enrolled and were treated medically with pyridostigmine or corticosteroids. Eye alignment, eye movements, and blepharoptosis were observed during the follow-up period. Stereoacuity was recorded before and at the end of follow-up using Titmus stereoscopic and major amblyoscopic tests. RESULTS: None of the patients had amblyopia or anisometropia, but all had blepharoptosis that improved within 2 weeks after medication was administered. There was only one case in which stereoacutiy failed to develop, and this patient had a long period of constant exotropia lasting 48 months. In the remaining four cases, there was constant exotropia lasting less than 4 months or intermittent exotropia throughout the follow-up period. All of these patients regained or maintained binocular vision. CONCLUSION: Prolonged constant eye misalignment may be attributable to impaired binocular vision, and prompt eye alignment may be necessary in childhood ocular myasthenia gravis. Therefore, treatment based on precise assessment by a neuro-ophthalmologist or pediatric ophthalmologist that evaluates even slight eye misalignment is essential in ensuring normal development of binocular vision.


Subject(s)
Blepharoptosis/etiology , Exotropia/etiology , Myasthenia Gravis/complications , Vision, Binocular/physiology , Blepharoptosis/physiopathology , Child, Preschool , Disease Progression , Exotropia/physiopathology , Female , Follow-Up Studies , Humans , Infant , Male , Myasthenia Gravis/physiopathology , Retrospective Studies , Time Factors
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