[The hemodynamic support of physical loading in patients with mitral valve prolapse]. / Gemodinamicheskoe obespechenie fizicheskoi nagruzki u bol'nykh s prolabirovaniem mitral'nogo klapana.

Bicycle ergometry and echocardiographic studies were carried out in 29 patients aged 17-29 years with first revealed mitral valve prolapse (MVP) without any signs of mitral regurgitation. According to bicycle ergometry, the patients manifested changes in hemodynamics pointing to dysfunction of the cardiovascular system. Echocardiography discovered a reduction of the mass and a rise of the rate of contraction of the circular fibers of the left ventricle, evidence of the myocardial genesis of the hemodynamic changes. Comparison of the findings of bicycle ergometry and echocardiography allowed a conclusion about the necessity of the follow-up of patients with MVP in spite of the high level of threshold load and the lack of the clinical signs of heart failure.

[Willebrand's factor, functional activity of blood platelets and antiaggregation activity of the vascular wall in ischemic heart disease]. / Faktor Villebranda, funktsional'naia aktivnost' trombotsitov i antiagregatsionnaia aktivnost' stenki sosudov pri ishemicheskoi bolezni serdtsa.

Fifty coronary male patients aged 34 to 63 (the mean age 46) and 32 normal male subjects aged 18 to 32 (mean age 23) were examined for the levels of Willebrand's factor, induced platelet aggregation, beta-thromboglobulin, thromboxane, prostacyclin levels, and vascular wall antiaggregation activity (by the cuff test). Basing on literature data and their own findings the authors come to a conclusion that elevated plasma concentration of Willebrand's factor combined with increased functional activity of platelets and reduced vascular wall antiaggregation activity is the key factor in the pathogenesis of atherosclerosis development and progress.

[Selection of psychoemotional load test for the diagnosis of hypertension]. / Vybor psikhoémotsional'noi nagruzki v diagnostike gipertonicheskoi bolezni.

The specificity of cardiovascular response to mental exercise of certain types was assessed in 65 normal males and 66 hypertensive patients. Mental arithmetic exercise provoked an increase in systolic rather than diastolic blood pressure. The clock and compass test evaluating spacial imagination, on the contrary, resulted in mostly diastolic hypertension. In hypertensive patients, this specific response is more marked and can be used as a diagnostic test. The comparison of arterial blood pressure and catecholamines excretion suggests that mental arithmetic exercise is associated with beta-adrenoreceptor activation, while the other exercise activates alpha-receptors. The magnitude of arterial blood pressure change is believed to be related to the emotional component, while the systolic/diastolic ratio would be determined by specific nature of mental exercise.

[Relation between hormonal and hemodynamics indices during emotional stress in healthy individuals and in hypertensive patients]. / Vzaimosviaz' gormonal'nykh i gemodinamicheskikh pokazatelei pri émotsional'nom napriazhenii u zdorovykh liudei i bol'nykh gipertonicheskoi bolezn'iu.

Relationships between hormonal and hemodynamic parameters were examined during emotional stress in normal subjects and patients with essential hypertension. Plasma renin activity, aldosterone, cortisol concentration in the plasma and ACTH level, urinary catecholamine excretion were assayed, and arterial blood pressure, heart rate, ECG were recorded in 29 normal controls and 39 hypertensive patients before and after exposure to emotional stress. The findings were processed using the cluster technique of multivariable statistical analysis. Emotional stress was shown to produce more correlations in the system of hormonal balance compared to resting conditions, the interhormonal correlations being more pronounced in hypertensive patients as compared to normal controls. Stress-induced hypertensive response was shown to be achieved via different means: predominantly sympathoadrenal activation in normal subjects and the activation of renin-angiotensin-aldosterone system in hypertensive patients.